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Chemical Structure| 210691-38-6 Chemical Structure| 210691-38-6

Structure of 210691-38-6

Chemical Structure| 210691-38-6

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Product Details of [ 210691-38-6 ]

CAS No. :210691-38-6
Formula : C10H7ClF3NO3S
M.W : 313.68
SMILES Code : O=S(C1=CC2=C(N(C(C(F)(F)F)=O)CC2)C=C1)(Cl)=O
MDL No. :MFCD09261241
InChI Key :HVXAIGDGDNQFMM-UHFFFAOYSA-N
Pubchem ID :11088306

Safety of [ 210691-38-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H290
Precautionary Statements:P501-P260-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 210691-38-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 210691-38-6 ]

[ 210691-38-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1198-97-6 ]
  • [ 210691-38-6 ]
  • 4-phenyl-1-(1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl)pyrrolidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
45% To lactam 9 (1.2 mmol) solution in THF, 2M n-butyllithum in hexanes (1.5 mL) was added at -75 C. The mixture was stirred for 30 min. To the mixture, a solution of 1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonylchloride(1.3 mmol) in THF was slowly added. The mixture was stirred at -75 C for 2 h and slowly warmed the mixture to 0 C. After 2 h the reaction mixture was quenched with sat. ammonium chloride stirred at 0 C and diluted with ethyl acetate. The organic layer was washed with brine and dehydrated with anhydrous sodium sulfate, evaporated with vacuum to yield crude solid. The crude solid was subjected to column purification resulted in pure solid. Yield 45%; white solid; Rf: 0.36 (hexane: ethyl acetate, 3:2); mp 206 C; IR (neat ) 3384.9, 3030.4, 2357.4, 1734.6, 1697.2, 1594.0 cm-1; 1H NMR (400MHz ,CDCl3) d 8.35 (d, J = 8.8 Hz, 1 H), 8.00 (s, 1 H), 7.96 -7.85 (m, 1 H), 7.37 - 7.28 (m, 3 H), 7.16 (d, J = 7.6 Hz, 2 H), 4.48 - 4.26 (m, 3 H), 3.81 (dd, J = 8.0, 10.0 Hz, 1 H), 3.63 (quin, J = 8.4 Hz, 1 H), 3.37 (t, J = 8.4 Hz, 2 H), 2.86 (dd, J = 8.3, 17.4 Hz, 1 H), 2.64 (dd, J = 9.3, 17.4 Hz, 1 H).
 

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