[ CAS No. 211122-38-2 ]

Name: 211122-38-2|Methyl 6-fluoro-5-methylnicotinate|98%
Brand: Ambeed
SKU: A463823
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Quality Control of [ 211122-38-2 ]

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Product Details of [ 211122-38-2 ]

CAS No. :	211122-38-2	MDL No. :	MFCD11616889
Formula :	C₈H₈FNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	169.15 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 211122-38-2 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501	UN#:	2811
Hazard Statements:	H301-H311-H331	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 211122-38-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 211122-38-2 ]

[ 211122-38-2 ] Synthesis Path-Downstream 1~20

1
2-fluoro-3-methylpyridine-5-carboxylic acid [ No CAS ]
[ 74-88-4 ]
[ 211122-38-2 ]

Yield	Reaction Conditions	Operation in experiment
85%	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	20.1 Step 1: Methyl 6-fluoro-5-methylnicotinate (103). A mixture of 5-methyl-6-fluoro-nicotinic acid 102 (7.0 g, 45 mmol), K2CO3 (13.7 g, 99 mmol) and methyl iodide (9.58 g, 67 mmol) in DMF (200 mL) was stirred for 16 h at room temperature. After dilution with water (50 mL), the reaction mixture was extracted with EtOAc (50 mL). The combined extracts were washed successively with sat. aqueous NaHCO3 solution (20 mL), sat. NaCl (2*20 mL) and dried (Na2SO4). Filtration and evaporation of the solvent gave the product 103 (6.5 g, 85%).
85%	With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	8.1 Step 1: Methyl 6-fluoro-5-methylnicotinate (50). Step 1: Methyl 6-fluoro-5-methylnicotinate (50). A mixture of 5-methyl-6-fluoro- nicotinic acid 49 (7.0 g, 45 mmol), K2C03 (13.7 g, 99 mmol), methyl iodide (9.58 g, 67 mmol) and DMF (200 mL) was stirred for 16 h at RT. After dilution with water (50 mL), the reaction mixture was extracted with EtOAc (50 mL). The organic phase was washed successively with saturated aqueous NaHC03 (20 mL), brine (2 x 20 mL) and dried (Na2S04). Filtration and evaporation of the solvent gave 50 (6.5 g, 85%).

Reference： [1]Current Patent Assignee: EXELIXIS INC - US2010/249071, 2010, A1 Location in patent: Page/Page column 64-65
[2]Current Patent Assignee: EXELIXIS INC - WO2017/4608, 2017, A1 Location in patent: Paragraph 0172

2
[ 211122-38-2 ]
[ 75-31-0 ]
[ 1246391-50-3 ]

Yield	Reaction Conditions	Operation in experiment
98.4%	at 90℃; for 12h; Sealed tube;	20.2 Step 2: Methyl 6-(isopropylamino)-5-methylnicotinate (104). In a sealed tube, a reaction mixture of isopropylamine (50 mL) and 103 (6.5 g, 38 mmol) was heated at 90° C. for 12 h. After it was cooled to room temperature, volatiles were removed in vacuo. The obtained residue was diluted with water and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated to afford 104 (7.9 g, 98.4%).
98.4%	at 90℃; for 12h; Sealed tube;	8.2 Step 2: Methyl 6-(isopropylamino)-5-methylnicotinate (51). Step 2: Methyl 6-(isopropylamino)-5-methylnicotinate (51). Isopropylamine (50 mL) and 50 (6.5 g, 38 mmol) were combined in a sealed tube and heated at 90 °C for 12 h. After cooling to RT, volatiles were removed in vacuo. The resulting residue was diluted with water and extracted with EtOAc. The combined organic layers were dried over Na2S04 and concentrated to afford 51 (7.9 g, 98.4%).

3
[ 753-90-2 ]
[ 211122-38-2 ]
5-methyl-6-((2,2,2-trifluoroethyl)amino)nicotinic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
32%	Stage #1: trifluoroethylamine; methyl 6-fluoro-5-methylnicotinate In 1-methyl-pyrrolidin-2-one at 220℃; for 2.5h; Microwave irradiation; Stage #2: With water; sodium hydroxide In methanol at 50℃; for 1h;	Carboxylic acid-55: 5-methyl-6-((2,2,2-trifluoroethyl)amino)nicotinic acid A mixture of methyl 6-fluoro-5-methylnicotinate (2.00 g, 11.8 mmol) and 2,2,2-trifluoroethanamine (9.37 g, 95 mmol) in N-methylpyrrolidone (24 mL) is stirred at 220 oC for 2.5 hours under microwave irradiation. The mixture is diluted with MeOH (30 mL), and 2 M aqueous sodium hydroxide solution (15 mL) is added to the mixture. After stirring at 50 oC for 1 hour, the mixture is acidified by 2 M hydrochloric acid, and extracted with EtOAc/hexane (100 mLx3). The combined organic layer is washed with water (100 mL), and dried over sodium sulfate. After filtration, the filtrate is concentrated in vacuo. The residue is crystallized from diisopropyl ether to give 884 mg (32 %) of the title compound as a pale pink solid. 1H-NMR (300 MHz, DMSO-d6) delta 8.49 (1H, s), 7.78 (1H, s), 7.17 (1H, t, J = 6.6 Hz), 4.35-4.21 (2H, m), 2.14 (3H, s) (a signal due to COOH is not observed), MS (ESI) m/z: 233 (M-H) -.

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2013/161308, 2013, A1 Location in patent: Paragraph 0312

4
[ 2358-54-5 ]
[ 211122-38-2 ]
[ 1404115-78-1 ]

Yield	Reaction Conditions	Operation in experiment
74%	Stage #1: 2,2,2-trifluoroethoxyethanol; methyl 6-fluoro-5-methylnicotinate With potassium <i>tert</i>-butylate In N,N-dimethyl-formamide at 18 - 25℃; for 1h; Stage #2: With water; sodium hydroxide In methanol; N,N-dimethyl-formamide at 18 - 25℃; for 1h;	Carboxylic acid-56: 5-methyl-6-(2-(2,2,2-trifluoroethoxy)ethoxy)nicotinic acid To a mixture of 2-(2,2,2-trifluoroethoxy)ethanol (1.64 g, 11.4 mmol) and potassium tert-butoxide (1.38 g, 12.3 mmol) in DMF (30 mL) is added 6-fluoro-5-methylnicotinate (1.60 g, 9.46 mmol) at 0 oC, and the mixture is stirred at rt for 1 hour. Then, MeOH (30 mL) and 0.7 M sodium hydroxide aqueous solution (45 mL) are added to the mixture. After stirring at rt for 1 hour, MeOH is evaporated in vacuo. The residual aqueous phase is acidified by 2 M hydrochloric acid, and the formed precipitate is collected by filtration to give 1.95 g (74%) of the title compound as a white solid. 1H-NMR (300 MHz, DMSO-d3) delta 12.98 (1H, br s), 8.55 (1H, s), 8.01 (1H, s), 4.52-4.49 (2H, m), 4.16 (2H, q, J = 9.5 Hz), 3.98-3.95 (2H, m), 2.19 (3H, s), MS (ESI) m/z: 280 (M+H) +.

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2013/161308, 2013, A1 Location in patent: Paragraph 0313

5
[ 211122-38-2 ]
4,4-difluoropiperidine hydrochloride [ No CAS ]
6-(4,4-difluoropiperidin-1-yl)-5-methylnicotinic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
39%	Stage #1: methyl 6-fluoro-5-methylnicotinate; 4,4-difluoropiperidine hydrochloride With caesium carbonate In N,N-dimethyl-formamide at 120℃; for 16h; Stage #2: With water; sodium hydroxide In methanol; N,N-dimethyl-formamide at 60℃; for 3h;	Carboxylic acid-62: 6-(4,4-difluoropiperidin-1-yl)-5-methylnicotinic acid To a mixture of 2,2,2-trifluoroethanol (3.84 g, 38.4 mmol) and cesium carbonate (8.33 g, 25.6 mmol) in DMF (20 mL) is added ethyl 6-(chloromethyl)-5-methylnicotinate hydrochloride (1.37 g, 6.39 mmol, Step-3). After stirring at 40 oC for 20 hours, 2 M aqueous sodium hydroxide solution (20 mL), water (20 mL), THF (20 mL), and EtOH (20 mL) are added to the mixture. After stirring at 60 oC for 3 hours, the mixture is acidified by 2 M hydrochloric acid (pH is around 4). The organic solvent is removed by evaporation, and the residual aqueous layer is extracted with EtOAc/hexane. The separated organic layer is washed with water, dried over sodium sulfate, and concentrated in vacuo. The residue is crystallized from hexane to give 1.06 g (66%) of the title compound as a white solid. 1H-NMR (300 MHz, DMSO-d6) delta 8.85 (1H, d, J = 1.5 Hz), 8.11 (1H, s), 4.84 (2H, s), 4.22-4.12 (2H, m), 2.40 (3H, s) (a signal due to COOH is not observed), MS (ESI) m/z: 248 (M-H) -.

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2013/161308, 2013, A1 Location in patent: Paragraph 0324

6
[ 211122-38-2 ]
5-methyl-6-((2,2,2-trifluoroethyl)amino)nicotinic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 1-methyl-pyrrolidin-2-one / 2.5 h / 22 °C / Microwave irradiation 2: water; sodium hydroxide / methanol / 1 h / 50 °C

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2014/68988, 2014, A1

7
[ 211122-38-2 ]
5-methyl-6-(3,3,3-trifluoropropoxy)nicotinic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C 1.2: 2 h / 20 °C 2.1: water / tetrahydrofuran / 0.08 h / 0 °C

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2014/68988, 2014, A1

8
[ 211122-38-2 ]
[ 1476027-21-0 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 °C 2: water; sodium hydroxide / tetrahydrofuran; ethanol / 1 h / 60 °C

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2014/68988, 2014, A1

9
[ 371-41-5 ]
[ 211122-38-2 ]
[ 1476025-68-9 ]

Yield	Reaction Conditions	Operation in experiment
93%	With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 3h;

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2014/68988, 2014, A1 Location in patent: Paragraph 0234

10
[ 2516-33-8 ]
[ 211122-38-2 ]
C₁₂H₁₅NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h;

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2014/68988, 2014, A1 Location in patent: Paragraph 0254

11
[ 15878-00-9 ]
[ 211122-38-2 ]
[ 1476026-04-6 ]

Reference： [1]Patent: WO2014/68988,2014,A1 .Location in patent: Paragraph 0265

12
[ 753-90-2 ]
[ 211122-38-2 ]
C₁₀H₁₁F₃N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In 1-methyl-pyrrolidin-2-one at 22℃; for 2.5h; Microwave irradiation;

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2014/68988, 2014, A1 Location in patent: Paragraph 0272

13
[ 2240-88-2 ]
[ 211122-38-2 ]
C₁₁H₁₂F₃NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: 3,3,3-Trifluoropropanol With sodium hydride In tetrahydrofuran at 0℃; for 0.0833333h; Stage #2: methyl 6-fluoro-5-methylnicotinate In tetrahydrofuran at 20℃; for 2h;

Reference： [1]Current Patent Assignee: RAQUALIA PHARMA INC. - WO2014/68988, 2014, A1 Location in patent: Paragraph 0237

14
[ 211122-38-2 ]
[ 1246391-51-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 12 h / 90 °C / Sealed tube 2: hydrogenchloride / water / 12 h / 80 °C

Reference： [1]Current Patent Assignee: EXELIXIS INC - WO2017/4608, 2017, A1

15
[ 67-56-1 ]
2-fluoro-3-methylpyridine-5-carboxylic acid [ No CAS ]
[ 211122-38-2 ]

Yield	Reaction Conditions	Operation in experiment
	With diazomethyl-trimethyl-silane In diethyl ether at 20℃; for 1h;	1-55: To a stirred soln of 2-fluoro-3-methyl-pyridine-5-carboxylic acid (3.50 g, 22.6 mmol) in MeOH (20 mL) was added 2M trimethylsilyldiazomethane in ethyl ether soln (22.0 mL, 44.0 mmol) at RT. After 1 h, acetic acid (8.0 mL) was added to quench the rxn. Solvent was removed under reduced pressure to provide compound 1-55.

Reference： [1]Current Patent Assignee: EXELIXIS INC - WO2017/4609, 2017, A1 Location in patent: Paragraph 0154

16
[ 211122-38-2 ]
[ 67-63-0 ]
C₁₁H₁₅NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydride In N,N-dimethyl-formamide; mineral oil for 3h;	1-56: To a stirred soln of compound 1-55 (2.0 g, 12 mmol) in anhydrous DMF (8.0 mL) was added iPrOH (0.90 g, 15 mmol) and 60% NaH in mineral oil (0.60 g, 15 mmol). After 3 h, water (100 mL) was added to quench the rxn. The mixture was extracted with EtOAc (2x150 mL), washed with brine, dried over sodium sulfate and concentrated. The residue was purified via Combi-flash column on silica gel using a solvent gradient from 0- 20% EtOAc in heptanes to afford compound 1-56.

Reference： [1]Current Patent Assignee: EXELIXIS INC - WO2017/4609, 2017, A1 Location in patent: Paragraph 0155

17
[ 211122-38-2 ]
[ 1011558-18-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 3 h 2: water; sodium hydroxide / methanol / 2 h / Reflux

Reference： [1]Current Patent Assignee: EXELIXIS INC - WO2017/4609, 2017, A1

18
[ 211122-38-2 ]
C₂₂H₁₈Cl₂N₂O₃ [ No CAS ]
C₂₉H₂₃Cl₂N₃O₅ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate In N,N-dimethyl-formamide at 110℃; for 12h;	43 Example 43: Compound 43 To a solution of 31-2 (200 mg, 465.88 µmol) and 43-1 (120 mg, 709.42 µmol) in N,N-dimethylformamide (5 ml), cesium carbonate (455 mg, 1.40 mmol) was added. The reaction mixture was stirred at 110 °C for 12 hours. After the reaction was completed, the mixture was added with water (20 ml), adjusted with 1 M of hydrochloric acid to pH=6, and extracted with ethyl acetate (30 ml) for 3 times. The combined organic phase was washed with saturated brine (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated to obtain a crude product. The crude product was separated by preparative chromatography to give the target compound 43. 1H NMR (400MHz, METHANOL-d4) δ = 8.98 (s, 1H), 8.44 (s, 1H), 7.52 - 7.48 (m, 2H), 7.47-7.41 (m, 1H), 6.75 (d, J=2.0 Hz, 1H), 6.52 (dd, J=2.8, 8.8 Hz, 1H), 5.98 (d, J=8.5 Hz, 1H), 4.84-4.84 (m, 2H), 3.12 - 2.98 (m, 2H), 2.82 - 2.73 (m, 2H), 2.30 (td, J=6.8, 13.6 Hz, 1H), 2.18 (s, 3H), 1.22 - 1.14 (m, 4H). MS m/z: 564.0 [M+H]+.

Reference： [1]Current Patent Assignee: CSPC PHARMACEUTICAL GROUP LIMITED - EP3632910, 2020, A1 Location in patent: Paragraph 0374

19
[ 211122-38-2 ]
4-(tert-butyl)-1H-pyrazole [ No CAS ]
6-(4-tert-butylpyrazol-1-yl)-5-methylpyridine-3-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C 2: methanol; sodium hydroxide / tetrahydrofuran / 1 h / 25 °C

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2020/207941, 2020, A1

20
[ 211122-38-2 ]
4-(tert-butyl)-1H-pyrazole [ No CAS ]
6-(4-tert-butylpyrazol-1-yl)-5-methylpyridine-3-carboxylic acid [ No CAS ]
methyl 6-(4-tert-butylpyrazol-1-yl)-5-methylpyridine-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 68.7% 2: 25.4%	With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 1h;	A.62.a Step a) Methyl 6-(4-tert-butylpyrazol-1-yl)-5-methyl-pyridine-3-carboxylate Methyl 6-fluoro-5-methylnicotinate (370 mg, 2.98 mmol) and K2C03 (1.03 g, 7.42 mmol)were combined and stirred in DMF (2 mL) for 10 minutes, then 4-tert-butylpyrazole (500mg, 2.96 mmol) was added and the reaction was stirred for 1 h at 100 °C. The reaction mixture was adjusted to pH 3-4 with HC1 (1 M), extracted with MTBE. The combined organic layer was washed with HC1 (1M) and brine, dried over Na2504, filtered and concentrated providing the title compound (555 mg, 2.03 mmol, 68.7%) and hydrolysed side product (6-(4-tert-butylpyrazol- l-yl)-5 -methyl-pyridine-3 -carboxylic acid, A. 62) (195.0 mg, 752.0 imol, 25.4%) as white solid.MS (ESI): m/z = 274.3 [M+Hj for title compoundMS (ESI): m/z = 260.2 [M+Hj for hydrolysed side product A.62

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2020/207941, 2020, A1 Location in patent: Page/Page column 216; 217

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 211122-38-2 ]

Quality Control of [ 211122-38-2 ]

Related Doc. of [ 211122-38-2 ]

Product Details of [ 211122-38-2 ]

Safety of [ 211122-38-2 ]

Application In Synthesis of [ 211122-38-2 ]

[ 211122-38-2 ] Synthesis Path-Downstream 1~20

Related Functional Groups of [ 211122-38-2 ]

Fluorinated Building Blocks

Esters

Related Parent Nucleus of [ 211122-38-2 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 211122-38-2 ]

Related Parent Nucleus of
[ 211122-38-2 ]