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Chemical Structure| 211244-92-7 Chemical Structure| 211244-92-7

Structure of 211244-92-7

Chemical Structure| 211244-92-7

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Product Details of [ 211244-92-7 ]

CAS No. :211244-92-7
Formula : C8H7N3O3S
M.W : 225.22
SMILES Code : O=C1C=CC2=CN=C(S(=O)(C)=O)NC2=N1

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Application In Synthesis of [ 211244-92-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 211244-92-7 ]

[ 211244-92-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 211244-81-4 ]
  • [ 211244-92-7 ]
YieldReaction ConditionsOperation in experiment
With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20℃; for 1h; To 670 mg (3.47 mmol) of <strong>[211244-81-4]2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one</strong> (synthesized via procedures found in J. Med. Chem. 2000, 43, 4606-4616) in CH2Cl2 (17 mL) was added 1.55 g (6.93 mmol) of mCPBA and the mixture stirred at ambient temperature for 1 hour. The reaction was concentrated directly and redissolved in dioxane (10 mL). To this solution was added 675 mg (2.25 mmol) of G-2 and 2.4 mL (17.3 mmol) of triethylamine. The reaction was heated to 100 C. for 6 hours. The reaction was cooled to ambient temperature, quenched with saturated NH4Cl and extracted with EtOAc (4×20 mL). The organic phase was dried over MgSO4 and concentrated. The residue was purified by flash column chromatography (EtOAc/hexanes) to afford 0-1 as a solid. Data for O-1: LC/MS: rt=2.01 min; m/z (M+H)=445.4 found; 445.2 required.
 

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