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Chemical Structure| 2136-72-3 Chemical Structure| 2136-72-3

Structure of 2136-72-3

Chemical Structure| 2136-72-3

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Product Details of [ 2136-72-3 ]

CAS No. :2136-72-3
Formula : C20H42O2
M.W : 314.55
SMILES Code : CCCCCCCCCCCCCCCCCCOCCO
MDL No. :MFCD00043351
Boiling Point : No data available

Safety of [ 2136-72-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 2136-72-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2136-72-3 ]

[ 2136-72-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2136-72-3 ]
  • [ 7075-11-8 ]
  • [ 1143624-15-0 ]
YieldReaction ConditionsOperation in experiment
With 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine; at 45℃; for 25h; Acyclovir was phosphorylated by addition of phosphorous oxychloride (POCl3). After 1-2h at 0C, acyclovir was extracted with ether as a phosphoryl dichloride. A 2N NaOH solution was added to an aqueous solution of the dichloride to bring the pH to about 9 to 10, converting the compound to the disodium form. Chromatography on Dowex 50 converted the disodium salt to acyclovir monophosphate. A solution of acyclovir monophosphate as its salt, such as tributylamine or trioctylamine, in pyridine was treated with batyl alcohol followed by triisopropylbenzenesulfonyl chloride (TIPS) at a temperature of 45C, for a period of 28h. The dark-colored solution was treated with water, followed by toluene, and the resulting solution was concentrated under reduced pressure. The crude product was purified by ion exchange chromatography followed by silica column chromatography to obtain the desired compound as a white chloroform- soluble powder in a yield of 50% with a purity > 95%. In a similar manner, 1-O-octadecyl-2,2-dimethoxy-1,3-propanediol was coupled with acyclovir monophosphate to yield the corresponding acyclovir derivative.
 

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