* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃;
(2S,4R)-tert-butyl 4-((tert-butyldimethyl silicon)-oxy)2-methylpyrrolidine-1-carboxylate (2.2 g, 6.98 mmol) is dissolved in THF (30 mL), followed by adding tetrabutylammonium fluoride (3.65 g, 14.0 mmol), and the reaction mixture reacts overnight at room temperature. Then the reaction mixture is poured into water (60 mL), and extracted with ethyl acetate (60 mL * 2), washed with saturated salt solution (60 mL * 2), dried with anhydrous Na2SO4, rotated to dryness and purified by column chromatography (PE : EA = 2 : 1), so as to obtain a yellow oily matter of 1.47 g, that is (2S,4R)-tert-butyl 4-hydroxyl-2-methylpyrrolidine-1-carboxylate with a yield of 99percent.
Reference：
[1] Patent: EP3401315, 2018, A1, . Location in patent: Paragraph 0106; 0111
[2] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1598 - 1611
[3] Journal of the American Chemical Society, 2008, vol. 130, # 3, p. 875 - 886
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20℃;
(2S,4R)-tert-butyl 4-((tert-butyldimethyl silicon)-oxy)2-methylpyrrolidine-1-carboxylate (2.2 g, 6.98 mmol) is dissolved in THF (30 mL), followed by adding tetrabutylammonium fluoride (3.65 g, 14.0 mmol), and the reaction mixture reacts overnight at room temperature. Then the reaction mixture is poured into water (60 mL), and extracted with ethyl acetate (60 mL * 2), washed with saturated salt solution (60 mL * 2), dried with anhydrous Na2SO4, rotated to dryness and purified by column chromatography (PE : EA = 2 : 1), so as to obtain a yellow oily matter of 1.47 g, that is (2S,4R)-tert-butyl 4-hydroxyl-2-methylpyrrolidine-1-carboxylate with a yield of 99%.
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