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Chemical Structure| 2145-27-9 Chemical Structure| 2145-27-9

Structure of 2145-27-9

Chemical Structure| 2145-27-9

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Product Details of [ 2145-27-9 ]

CAS No. :2145-27-9
Formula : C9H5FO3
M.W : 180.13
SMILES Code : O=C1OC2=C(C=CC(F)=C2)C(O)=C1
MDL No. :MFCD11845381
InChI Key :FSWKHPJLMMGTBV-UHFFFAOYSA-N
Pubchem ID :54694570

Safety of [ 2145-27-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 2145-27-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2145-27-9 ]

[ 2145-27-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1076-38-6 ]
  • [ 2145-27-9 ]
  • [ 66233-72-5 ]
  • [ 4865-84-3 ]
YieldReaction ConditionsOperation in experiment
With hydroxylamine hydrochloride; sodium methylate; In methanol; sodium bicarbonate; EXAMPLE 9 Preparation of 6-Fluoro-1,2-benzisoxazole-3-acetic acid STR70 A solution of sodium methoxide (22.3 g, 0.412 mol) in methanol is added to a solution of hydroxylamine hydrochloride (30.4 g, 0.438 mol) in methanol. The resultant mixture is stirred at room temperature for 30 minutes and filtered. The filtrate is added to a refluxing solution of 7-fluoro-4-hydroxycoumarin (18.5 g, 0.103 mol) in methanol. The reaction mixture is refluxed overnight and concentrated in vacuo to obtain a yellow solid. A solution of the solid in a sodium hydrogen carbonate solution is washed with ether and acidified with 6N hydrochloric acid. The resultant precipitate is filtered and dried to give a solid which is recrystallized from water to give the title product as a beige solid, mp 132-133 C. Using essentially the same procedure, but substituting 4-hydroxycoumarin for 7-fluoro-4-hydroxycoumarin, 1,2-benzisoxazole-3-acetic acid is obtained as an off-white solid, mp 123-127 C.
 

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