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Chemical Structure| 2158-02-3 Chemical Structure| 2158-02-3

Structure of 2158-02-3

Chemical Structure| 2158-02-3

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Product Details of [ 2158-02-3 ]

CAS No. :2158-02-3
Formula : C5H10N2O2
M.W : 130.15
SMILES Code : O=C(N1CCOCC1)N
MDL No. :MFCD00085717

Safety of [ 2158-02-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 2158-02-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2158-02-3 ]

[ 2158-02-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-91-8 ]
  • [ 1103738-17-5 ]
  • [ 2158-02-3 ]
YieldReaction ConditionsOperation in experiment
64% With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; To a solution of <strong>[1103738-17-5](3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid</strong> (5.0 g, 24.5 mmol) in THF (100 mL, 20X) was added TBTU (11.8 g, 1.5 equiv), N-methylmorpholine (NMM, 4.1 mL, 1.5 equiv) and the mixture was stirred at 20 C. for 30 min. Morpholine (3.2 mL, 1.5 equiv) was then added, and the reaction mixture was stirred at 20 C. for an additional 6 h. The solid was filtered off by filtration and the cake was washed with THF (10 mL, 2X *2). The organic solution was concentrated under vacuum and the residue was purified by silica gel column chromatography (hexanes:EtOAc, from 1:4 to 4:1) to afford 4.3 g of the desired morpholine amide (64%) as a white solid. 1H NMR (CDCl3), delta 6.02 (d, J=3.2 Hz, 1H), 5.11 (br s, 1H), 4.62 (d, J=3.2 Hz, 1H), 4.58 (d, J=3.2 Hz, 1H), 3.9-3.5 (m, 8H), 1.51 (s, 3H), 1.35 (s, 3H).
 

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