Alternatived Products of [ 21630-48-8 ]
Product Details of [ 21630-48-8 ]
CAS No. : | 21630-48-8 |
MDL No. : | MFCD00023436 |
Formula : |
C12H11N3O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
229.24
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 21630-48-8 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 21630-48-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 21630-48-8 ]
Yield | Reaction Conditions | Operation in experiment |
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2-Benzylamino-5-nitropyridin, Ra/Ni, H2; |
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- 2
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[ 21626-41-5 ]
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[ 21630-48-8 ]
Yield | Reaction Conditions | Operation in experiment |
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In ethanol; dichloromethane |
1.2 2.
2. 2-Benzylamino-5-aminopyridine A mixture of 2-benzylamino-5-nitropyridine (2.02 g) and 10% Pd/C (202 mg) in ethanol (20 mL) was placed in a Paar bottle and shaken under hydrogen (50 PSI) for 3 h. The mixture was filtered through Celite using dichloromethane and concentrated in vacuo to afford 1.76 g of 2-benzylamino-5-aminopyridine as a burgundy oil. |
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With hydrazine hydrate In 1,4-dioxane at 20℃; Inert atmosphere; |
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Reference:
[1]Current Patent Assignee: LIGAND PHARMACEUTICALS INC - US6143760, 2000, A
[2]Kinarivala, Nihar; Patel, Ronak; Boustany, Rose-Mary; Al-Ahmad, Abraham; Trippier, Paul C.
[Journal of Medicinal Chemistry, 2017, vol. 60, # 23, p. 9739 - 9756]
- 3
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[ 21630-48-8 ]
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[ 87-13-8 ]
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diethyl (2-benzylamino-5-pyridylaminomethylene)malonate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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1.3 3.
3. Diethyl(2-benzylamino-5-pyridylaminomethylene)malonate A mixture of 2-benzylamino-5-aminopyridine (1.76 g) and diethyl ethoxymethylenemalonate (1.78 mL, 8.82 mmol) was heated at 130° C. for 2 h. While warm, the mixture was evacuated. After cooling, the product was triturated with 2:1 hexanes/ether and collected to give 2.74 g of diethyl (2-benzylamino-5-pyridylaminomethylene)malonate as a gold solid. |
- 4
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1-{N-[5-(benzo[1,3]dioxol-5-ylazo)pyridin-2-yl]-N-benzylamino}pyridinium bromide
[ No CAS ]
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[ 21630-48-8 ]
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[ 14268-66-7 ]
Yield | Reaction Conditions | Operation in experiment |
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With formic acid; platinum on carbon; triethylamine In acetonitrile at 0℃; regioselective reaction; |
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- 5
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[ 46224-49-1 ]
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[ 21630-48-8 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: potassium carbonate / dichloromethane / 0.33 h / Cooling with ice
2: acetone / 72 h / 20 °C / Inert atmosphere
3: triethylamine; platinum on carbon; formic acid / acetonitrile / 0 °C |
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- 6
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pyridinium N-[5′-(benzo[1,3]dioxol-5-ylazo)pyridin-2-yl]aminide
[ No CAS ]
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[ 21630-48-8 ]
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[ 14268-66-7 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: acetone / 72 h / 20 °C / Inert atmosphere
2: triethylamine; platinum on carbon; formic acid / acetonitrile / 0 °C |
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- 7
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[ 100-39-0 ]
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[ 21630-48-8 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: acetone / 72 h / 20 °C / Inert atmosphere
2: triethylamine; platinum on carbon; formic acid / acetonitrile / 0 °C |
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- 8
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[ 541-41-3 ]
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[ 21630-48-8 ]
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ethyl (6-(benzylamino)pyridin-3-yl)carbamate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
26% |
In 1,4-dioxane at 20℃; Inert atmosphere; Darkness; |
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- 9
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[ 4548-45-2 ]
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[ 21630-48-8 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: triethylamine / isopropyl alcohol / 3 h / Reflux; Inert atmosphere
2: hydrazine hydrate / 1,4-dioxane / 20 °C / Inert atmosphere |
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- 10
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[ 100-46-9 ]
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[ 21630-48-8 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: triethylamine / isopropyl alcohol / 3 h / Reflux; Inert atmosphere
2: hydrazine hydrate / 1,4-dioxane / 20 °C / Inert atmosphere |
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