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Chemical Structure| 216591-43-4 Chemical Structure| 216591-43-4

Structure of 216591-43-4

Chemical Structure| 216591-43-4

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Product Details of [ 216591-43-4 ]

CAS No. :216591-43-4
Formula : C6H8N2O2
M.W : 140.14
SMILES Code : O=[N+](C1=CN(CC)C=C1)[O-]

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Application In Synthesis of [ 216591-43-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 216591-43-4 ]

[ 216591-43-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5930-94-9 ]
  • [ 75-03-6 ]
  • [ 216591-43-4 ]
YieldReaction ConditionsOperation in experiment
82% With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 2.5h; Method G Synthesis of 5-tert-Butyl-3-[3-(1-ethyl-1H-pyrrol-3-yl)-ureido]-thiophene-2-carboxylic acid methyl ester. (Example 18) [Show Image] step 1; A solution of <strong>[5930-94-9]3-nitropyrrole</strong> (446 mg, 4.16 mmol), cesium carbonate (1.63 g, 4.99 mmol), iodoethane (998 ul, 12.48 mmol) in DMF (10 ml) was stirred for 2.5 hours at 20C. The reaction was diluted with ethyl acetate, washed 1N hydrochloric acid (3x), dried with sodium sulfate and the solvent removed in vacuo. The crude material was purified by flash chromatography with 100% dichloromethane affording 480 mg (82%) as an oil.
 

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