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Chemical Structure| 220179-93-1 Chemical Structure| 220179-93-1

Structure of 220179-93-1

Chemical Structure| 220179-93-1

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Product Details of [ 220179-93-1 ]

CAS No. :220179-93-1
Formula : C11H20O3
M.W : 200.27
SMILES Code : O=C(OC(C)(C)C)C1CCC(O)CC1
MDL No. :MFCD24396560

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Application In Synthesis of [ 220179-93-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 220179-93-1 ]

[ 220179-93-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 456-24-6 ]
  • [ 220179-93-1 ]
  • [ 1124173-87-0 ]
YieldReaction ConditionsOperation in experiment
38% With potassium tert-butylate; In tetrahydrofuran; at 90℃; for 0.0666667h;Microwave irradiation; Potassium tert-butoxide (2.7 Ig, 24.17mmol) was added to a stirred solution of tert-butyl A- hydroxycyclohexanecarboxylate (2.42g, 12.08mmol) and <strong>[456-24-6]2-fluoro-5-nitropyridine</strong> (1.72g, 12.08mmol) in THF (18mL) under nitrogen. The reaction mixture was heated in the microwave at 900C for 4 min before being cooled and quenched with saturated ammonium chloride solution (5OmL). The mixture was extracted with ethyl acetate (2x50mL) and the organics washed with water (5OmL). The organic phase was dried (MgSO4) and solvent removed in vacuo. The crude product was purified by flash silica chromatography, eluting with 0 to 20percent ethyl acetate in isohexane to afford the title compound as yellow solid (1.35g, 38percent). 1R NMR (400 MHz, CDCl3) deltal.45 - 1.49 (9H, m), 1.51 -2.35 (9H, m), 5.18 - 5.38 (IH, m), 6.78 (IH, m), 8.31 - 8.35 (IH, m), 9.05 (IH, d). m/z 266.92 (M-tBu)
  • 2
  • [ 220179-93-1 ]
  • [ 83883-26-5 ]
  • C27H38O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
3.6 g With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20℃; for 10h;Inert atmosphere; Cooling with ice; Under a nitrogen atmosphere, 3.0 g of the compound represented by the formula (I-3-1), 4.4 g of the compound represented by the formula (I-3-2), 0.7 g of N, N-dimethylaminopyridine And 40 mL of dichloromethane were added. 2.3 g of diisopropylcarbodiimide was added dropwise while cooling with ice, and the mixture was stirred at room temperature for 10 hours. The precipitate was removed by filtration, and the filtrate was washed successively with 1percent hydrochloric acid, water and brine. Purification by column chromatography (silica gel, dichloromethane / hexane) gave 3.6 g of a compound represented by the formula (I-3-3).
 

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