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Chemical Structure| 220757-74-4 Chemical Structure| 220757-74-4

Structure of 220757-74-4

Chemical Structure| 220757-74-4

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Product Details of [ 220757-74-4 ]

CAS No. :220757-74-4
Formula : C16H16ClN3OS
M.W : 333.84
SMILES Code : ClC=1C(=CN=C(C1C)CSC2=NC=3C=CC(OC)=CC3N2)C
MDL No. :MFCD09840353

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Application In Synthesis of [ 220757-74-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 220757-74-4 ]

[ 220757-74-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 220757-74-4 ]
  • [ 124-41-4 ]
  • [ 73590-85-9 ]
  • 2
  • [ 220757-74-4 ]
  • [ 73590-85-9 ]
YieldReaction ConditionsOperation in experiment
85% With sodium methylate; In methanol; ethyl acetate; Example 22 First, 277 mg (0.92 mmol) of 5-methoxy-2-[(4-chloro-3,5-dimethyl-2-pyridyl)methyl]thio}-1H-benzimidazole obtained in Example 21 and 1.00 g (5.20 mmol) of methanol 28percent solution of sodium methoxide were introduced to a 3-necked flask (30 ml volume) equipped with a thermometer, a magnetic stirrer and a condenser tube, and the mixture was agitated for 10 hours while being slowly refluxed. Then the mixture was neutralized with dilute hydrochloric acid. Ethyl acetate (10 ml) was added thereto and an organic layer was separated, and an aqueous layer was extracted twice with 10 ml of ethyl acetate. The extracts and the above mentioned organic layer were combined and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 232 mg of 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio}-1H-benzimidazole (yield of 85percent) with revealing the properties. 1H-NMR spectrum (270 MHz, DMSO-d6, TMS, ppm), delta:2.26(s, 3H), 2.42(s, 3H), 3.59(s, 3H), 3.77(s, 3H), 4.62(s, 2H), 6.70(dd, 1H, J=3.0 Hz, 8.9 Hz), 6.90(bs, 1H), 7.27(d, 1H, J=8.9 Hz), 8.07(s, 1H), 12.30(bs, 1H)
 

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