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Chemical Structure| 22091-49-2 Chemical Structure| 22091-49-2

Structure of 22091-49-2

Chemical Structure| 22091-49-2

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Product Details of [ 22091-49-2 ]

CAS No. :22091-49-2
Formula : C10H8BrNO
M.W : 238.08
SMILES Code : CC1=NC(C2=CC=C(Br)C=C2)=CO1
MDL No. :MFCD09261234

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Application In Synthesis of [ 22091-49-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22091-49-2 ]

[ 22091-49-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 60-35-5 ]
  • [ 7500-37-0 ]
  • [ 22091-49-2 ]
YieldReaction ConditionsOperation in experiment
26.6% With boron trifluoride diethyl etherate; In 5,5-dimethyl-1,3-cyclohexadiene; for 30h;Reflux; 2-(4-Bromophenyl)-2-oxoethyl acetate (12.38 g, 45.7 mmol, 1 equiv), xylene(120 mL), acetamide (13.50 g, 229 mmol, 5 equiv), boron trifluoride etherate (2.285 mL) were sequentially added to 250 mL of eggplantIn a row bottle, the temperature was raised to reflux reaction, and the reaction was carried out for 30 hours. After the reaction is completed, xylene is distilled off, and the residue is dissolved in dichloromethane, and steamed.The dichloromethane layer was washed with distilled water, dried over anhydrous sodium sulfate and evaporated.Flash column chromatography gave 3.06 g of a yellow solid.The yield was 26.6%.
 

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