Alternatived Products of [ 22252-14-8 ]
Product Details of [ 22252-14-8 ]
| CAS No. : | 22252-14-8 |
MDL No. : | MFCD00027595 |
| Formula : |
C16H14O
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
222.28
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 22252-14-8 ]
| Signal Word: | |
Class: | |
| Precautionary Statements: | |
UN#: | |
| Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 22252-14-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 22252-14-8 ]
- 1
-
[ 110-91-8 ]
-
[ 22252-14-8 ]
-
[ 538-28-3 ]
-
4-(4-phenyl-6-<i>p</i>-tolyl-pyrimidin-2-yl)-morpholine
[ No CAS ]
- 2
-
[ 70591-20-7 ]
-
[ 22252-14-8 ]
-
C31H26N2O
[ No CAS ]
- 3
-
[ 583-06-2 ]
-
[ 106-38-7 ]
-
[ 22252-14-8 ]
- 4
-
[ 583-06-2 ]
-
[ 5720-05-8 ]
-
[ 22252-14-8 ]
- 5
-
[ 624-31-7 ]
-
[ 936-59-4 ]
-
[ 22252-14-8 ]
| Yield | Reaction Conditions | Operation in experiment |
| 83% |
With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 20 - 90℃; under 750.075 Torr; for 16h;Inert atmosphere; |
General procedure: A mixture of Pd(OAc)2 (4.5 mg, 0.02 mmol), PPh3 (11.2 mg, 0.04 mmol), iodobenzene (1a) (82 mg, 0.4mmol), <strong>[936-59-4]3-chloropropiophenone</strong> (2a) (87 mg, 0.5 mmol), and K2CO3 (166 mg, 1.2 mmol) in DMF (2.5 mL) was stirred under a N2 atmosphere at room temperature for 10 min, and then heated at 90 C for 16 h. The reaction was then cooled to ambient temperature and diluted with CH2Cl2 (10 mL) before being filtered through a short pad of silica gel. The silica pad was rinsed with DCM (5 mL), and the combined filtrates were washed with brine (15 mL), dried over anhydrous Na2SO4. The solvent was then removed under reduced pressure to give the crude product as a residue, which was purified by silica gel column chromatography eluting with a mixture of petroleum ether (60-90 C)/EtOAc (v/v = 30:1). |
- 6
-
[ 1040745-70-7 ]
-
[ 22252-14-8 ]
-
3-(cyclopentylsulfonyl)-1-phenyl-3-(p-tolyl)propan-1-one
[ No CAS ]
- 7
-
[ 22252-14-8 ]
-
[ 6752-16-5 ]
-
2-phenyl-4-(p-tolyl)pyrido[2’,3’:3,4]pyrazolo[1,5-a]pyrimidine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 93% |
With cholin hydroxide; In neat (no solvent); at 80℃; for 0.666667h;Green chemistry; |
General procedure: ChOH (1 mmol) was added to a mixture of <strong>[6752-16-5]1H-pyrazolo[3,4-b]pyridin-3-amine</strong> (1,1.0 mmol) and (2E)-1,3-diphenylprop-2-en-1-one (2a, 1.0 mmol) in a 10-mL reaction flask equipped with a magnetic stirrer. The resulting mixture was stirred for the appropriate time at 80 C. After completion of the reaction (confirmed by TLC, hexane:EtOAc 1:1), 2 mL of water was added and stirred 60 for minutes at room temperature. The solid product was filtered and washed with water. The obtained crude product was recrystallized from ethanol to yield the pure product 3a. The same method was adopted for the synthesis of all the targeted products 3a-3aj. |
- 8
-
[ 6290-05-7 ]
-
[ 22252-14-8 ]
-
C24H23NO5
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 90% |
With 1,4-diaza-bicyclo[2.2.2]octane; copper diacetate; In N,N-dimethyl-formamide; at 80℃; for 8h; |
(E)-1-Phenyl-3-(p-tolyl)prop-2-en-1-one (0.0555 g, 0.25 mmol) was added to a 25 mL reaction tube.Diethyl Iminodiacetate (0.0945 g, 0.5 mmol),Triethylenediamine (0.0251 g, 0.25 mmol) and Cu(OAc) 2 (0.0498 g, 0.25 mmol),It was then reacted in DMF (1.0 mL) at 80 C for 8 h. After the end of the reaction by TLC,Extract with 10 mL of a saturated aqueous solution of sodium chloride and ethyl acetate (3×10 mL).After the organic layers were combined and dried over anhydrous sodium sulfate, the solvent was removed by a rotary evaporator, and finally subjected to column chromatography (eluent was a mixture of petroleum ether and ethyl acetate in a volume ratio of 2:1).The target compound was obtained in 90% yield as a white solid. |
Categories
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
110K+ Compounds
Competitive Price
1-2 Day Shipping
