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Chemical Structure| 22282-72-0 Chemical Structure| 22282-72-0
Chemical Structure| 22282-72-0

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Product Details of 2-Hydroxy-isonicotinic acid

CAS No. :22282-72-0
Formula : C6H5NO3
M.W : 139.11
SMILES Code : O=C(O)C1=CC=NC(O)=C1
MDL No. :MFCD01318566
InChI Key :BXHCJLRTXPHUGH-UHFFFAOYSA-N
Pubchem ID :280756

Safety of 2-Hydroxy-isonicotinic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of 2-Hydroxy-isonicotinic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22282-72-0 ]

[ 22282-72-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 10386-27-3 ]
  • [ 22282-72-0 ]
  • 2
  • [ 22282-72-0 ]
  • [ 127838-58-8 ]
YieldReaction ConditionsOperation in experiment
With borane-THF; In tetrahydrofuran; at 0 - 25℃; for 2h; Preparative Example 4.30 4-[(4-iodo- lH-pyrazol- 1 -yl)methyl]py Step 1 : Borane-THF (29 mL, 1.0 M) was added to a solution of 2-oxo-l,2- dihydropyridine-4-carboxylic acid (1 g, 7.19 mmol) in THF (15 mL) at 0 C. The mixture was stirred at 25 C for 2 hours. Methanol was added and the mixture was concentrated under reduced pressure to afford 4-(hydroxymethyl)pyridin-2(lH)-one. MS ESI calc'd. for C6H8 02 [M + H]+ 126, found 126. XH NMR (400 MHz, CD3OD) delta 7.40 (d, J= 6.8 Hz, 1H), 6.58 (s, 1H), 6.38 (d, J= 6.4 Hz, 1H), 4.52 (s, 2H).
 

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