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Chemical Structure| 223492-51-1 Chemical Structure| 223492-51-1

Structure of 223492-51-1

Chemical Structure| 223492-51-1

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Product Details of [ 223492-51-1 ]

CAS No. :223492-51-1
Formula : C24H33NO3
M.W : 383.52
SMILES Code : CC(C)(C)C1=CC=C(C=C1)CNCC2=CC=CC(OCC(OC(C)(C)C)=O)=C2
MDL No. :MFCD09955340

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Application In Synthesis of [ 223492-51-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 223492-51-1 ]

[ 223492-51-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 223492-51-1 ]
  • [ 42899-76-3 ]
  • [ 223492-52-2 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 0℃; for 2h; {3-[(4-Tert-Butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy acetic acid tert-butyl ester. To a solution of {3-[(4-tert-butyl-benzylamino)-methyl]-phenoxy}acetic acid tert-butyl ester (10.0 g, 26.1 mmol), prepared in Step A, in CH2Cl2 (75 mL) at 0° C. was added triethylamine (8.0 mL, 57.4 mmol), and <strong>[42899-76-3]pyridine-3-sulfonyl chloride hydrochloride</strong> (6.10 g, 28.7 mmol), of Preparation 2. The mixture was stirred for 0.5 h, the ice bath was removed, and the mixture was stirred for an additional 1.5 h. A 1:1 solution of water:aqueous saturated sodium bicarbonate was added to the solution, and the product was extracted into CH2Cl2 (3.x.). The combined organic solutions were dried over MgSO4 and concentrated in vacuo and the product was purified via silica gel chromatography (2:1 Hex:EtOAc) to give the title compound of Step B (11.0 g) as a clear oil. 1H NMR (400 MHz, CDCl3) delta 9.01 (s, 1H), 8.75 (d, 1H), 7.97 (d, 1H), 7.38 (m, 1H), 7.11-7.23 (m, 3H), 6.97 (d, 2H), 6.71 (d, 1H), 6.65 (d, 1H), 6.60 (s, 1H), 4.40 (s, 2H), 4.32 (s, 4H), 1.48 (s, 9H), 1.26 (s, 9H); MS 525 (M+1).
 

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