[ CAS No. 2239-83-0 ] {[proInfo.proName]}

Name: 2239-83-0|(2-Methylpyrimidin-5-yl)methanol|98%
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Quality Control of [ 2239-83-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 2239-83-0 ]

Product Details of [ 2239-83-0 ]

CAS No. :	2239-83-0	MDL No. :	MFCD09414732
Formula :	C₆H₈N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	HOBMGFDJYBEWLS-UHFFFAOYSA-N
M.W :	124.14	Pubchem ID :	14686706
Synonyms :

Calculated chemistry of [ 2239-83-0 ]

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.33
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	33.13
TPSA :	46.01 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.26 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.41
Log Po/w (XLOGP3) :	-0.28
Log Po/w (WLOGP) :	0.13
Log Po/w (MLOGP) :	-0.61
Log Po/w (SILICOS-IT) :	1.17
Consensus Log Po/w :	0.36

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-0.86
Solubility :	17.1 mg/ml ; 0.138 mol/l
Class :	Very soluble
Log S (Ali) :	-0.23
Solubility :	73.6 mg/ml ; 0.593 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.82
Solubility :	1.86 mg/ml ; 0.015 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.2

Safety of [ 2239-83-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2239-83-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 2239-83-0 ]
Downstream synthetic route of [ 2239-83-0 ]

[ 2239-83-0 ] Synthesis Path-Upstream 1~3

1
[ 90905-33-2 ]
[ 2239-83-0 ]

Yield	Reaction Conditions	Operation in experiment
51%	With sodium tetrahydroborate In methanol at 0 - 15℃; for 3 h;	To a mixture of 2-methylpyrimidine-5-carbaldehyde (8 g, 66 mmol, compound 44b) in MeOH (100 mL) was added NaBH₄ (7.5 g, 197 mmol) at 0 °C, and the resulting reaction mixture was stirred at 15°C for 3 hrs. Then the reaction mixture was quenched by saturated NH₄C1 solution (30 mL), extracted by ethyl acetate (20 mL) three times. The separated organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to afford (2-methylpyrimidin-5-yl)methanol (4.1 g, 51percent, compound 44c) as a white solid.
39%	at 0 - 20℃; for 1 h;	A solution of 2-methyl-pyrimidine-5-carbaldehyde (5 g, 41 mmol) in MeOH (100 mL) was added NaBH₄(2.3 g, 61.5 mmol) at 0° C. in portions and the resulting mixture was stirred at room temperature for 1 h. The solvent was removed under reduced pressure to give the remains, which was suspended in H₂O (20 mL) and extracted with EtOAc (5×50 ml). The organic layer was dried over Na₂SO₄and concentrated to afford the title compound (2 g, yield: 39percent). ¹H NMR (CDCl₃400 MHz): δ8.64 (s, 2H), 4.72 (s, 2H), 2.73 (s, 3H).

Reference： [1] Patent: WO2016/180695, 2016, A1, . Location in patent: Page/Page column 153
[2] Patent: US2014/107340, 2014, A1, . Location in patent: Paragraph 0121
[3] Patent: US2008/275037, 2008, A1, . Location in patent: Page/Page column 29
[4] Patent: WO2010/33168, 2010, A2, . Location in patent: Page/Page column 80-81

2
[ 5194-32-1 ]
[ 2239-83-0 ]

Yield	Reaction Conditions	Operation in experiment
62.6%	at 20℃; for 3 h;	Step 1 (2-methylpyrimidin-5-yl)methanol To a solution of 2-methylpyrimidine-5-carboxylic acid (150 mg, 1.23 mmOl) in ethanol (5 mL) was added sodium borohydride(93 mg, 2.46 mmol). The mixture was stirred at room temperature for 3 h. It was quenched with aqueous HC1 (2 N, 2 mL), extracted with DCM, dried over sodium sulfate, filtered and concentrated give the yellow oil product (2-methylpyrimidin-5-yl)methanol (95 mg, 62.6percent). LCMS MH⁺ 125.
62.6%	With sodium tetrahydroborate In ethanol at 20℃; for 3 h;	To a solution of 2-methylpyrimidine-5-carboxylic acid (150 mg, 1.23 mml) in ethanol (5 mL) was added sodium borohydride (93 mg, 2.46 mmol). The mixture was stirred at room temperature for 3 h. It was quenched with aqueous HCl (2 N, 2 mL), extracted with DCM, dried over sodium sulfate, filtered and concentrated give the yellow oil product (2-methylpyrimidin-5-yl)methanol (95 mg, 62.6percent). LCMS MH⁺ 125.

Reference： [1] Patent: WO2014/143799, 2014, A2, . Location in patent: Page/Page column 387
[2] Patent: US2014/275528, 2014, A1, . Location in patent: Paragraph 0309; 0310

3
[ 126504-91-4 ]
[ 126504-92-5 ]
[ 2239-83-0 ]

Reference： [1] Chemische Berichte, 1990, vol. 123, # 9, p. 1885 - 1889

[ 2239-83-0 ] Synthesis Path-Downstream 1~88

1
[ 126504-91-4 ]
[ 126504-92-5 ]
[ 2239-83-0 ]

Reference： [1]Chemische Berichte,1990,vol. 123,p. 1885 - 1889

2
[ 90905-33-2 ]
[ 2239-83-0 ]

Yield	Reaction Conditions	Operation in experiment
51%	With sodium tetrahydroborate; In methanol; at 0 - 15℃; for 3h;	To a mixture of <strong>[90905-33-2]2-methylpyrimidine-5-carbaldehyde</strong> (8 g, 66 mmol, compound 44b) in MeOH (100 mL) was added NaBH4 (7.5 g, 197 mmol) at 0 °C, and the resulting reaction mixture was stirred at 15°C for 3 hrs. Then the reaction mixture was quenched by saturated NH4C1 solution (30 mL), extracted by ethyl acetate (20 mL) three times. The separated organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to afford (2-methylpyrimidin-5-yl)methanol (4.1 g, 51percent, compound 44c) as a white solid.
39%	With methanol; sodium tetrahydroborate; at 0 - 20℃; for 1h;	A solution of <strong>[90905-33-2]2-methyl-pyrimidine-5-carbaldehyde</strong> (5 g, 41 mmol) in MeOH (100 mL) was added NaBH4 (2.3 g, 61.5 mmol) at 0° C. in portions and the resulting mixture was stirred at room temperature for 1 h. The solvent was removed under reduced pressure to give the remains, which was suspended in H2O (20 mL) and extracted with EtOAc (5×50 ml). The organic layer was dried over Na2SO4 and concentrated to afford the title compound (2 g, yield: 39percent). 1H NMR (CDCl3 400 MHz): delta8.64 (s, 2H), 4.72 (s, 2H), 2.73 (s, 3H).
	With methanol; sodium tetrahydroborate; at 0℃; for 0.5h;	B) (2-Methylpyrimidin-5-yl)methanolA solution of <strong>[90905-33-2]2-methylpyrimidine-5-carbaldehyde</strong> (6.48 g, 53.1 mmol) in methanol (320 mL) was cooled to 0° C. and treated with sodium tetrahydroborate (2.9 g, 77 mmol). After 30 min, the reaction was treated with H2O (50 mL) and extracted with EtOAc (250 mL.x.15). The organic layers were combined and dried over MgSO4 and concentrated to yield a white solid.

A solution of <strong>[90905-33-2]2-methylpyrimidine-5-carbaldehyde</strong> (7.5 g, 0.058 mol) in methanol (370 mL, 9.1 mol) was cooled to 0 0C and treated with sodium tetrahydroborate (3.4 g, 0.090 mol). After 30 min, the reaction was quenched with eq H2O (200 mL) and extracted with ethyl acetate. The organic layer was dried over MgSO4 and concentrated to give the title compound as a yellow solid.

Reference： [1]Patent: WO2016/180695,2016,A1 .Location in patent: Page/Page column 153
[2]Patent: US2014/107340,2014,A1 .Location in patent: Paragraph 0121
[3]Patent: US2008/275037,2008,A1 .Location in patent: Page/Page column 29
[4]Patent: WO2010/33168,2010,A2 .Location in patent: Page/Page column 80-81

3
[ 2239-83-0 ]
[ 1073428-44-0 ]

Yield	Reaction Conditions	Operation in experiment
	With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methane; toluene; at 0 - 20℃; for 18.0h;	C) 5-(Azidomethyl)-2-methylpyrimidineA solution of <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> (0.82 g, 6.6 mmol) in toluene (30 mL) and methylene chloride (40 mL) at 0 C. was treated with diphenylphosphonic azide (2.8 mL, 13 mmol) followed by 1,8-diazabicyclo[5.4.0]undec-7-ene (2.0 mL, 13 mmol) and stirred at 0 C. for 2 h. After being further stirred at rt for 16 h, the reaction mixture was diluted with water (50 mL) and methylene chloride (50 mL). The organic layer was separated and washed with brine, dried (Mg2SO4), filtered, and concentration. The residue was purified by silica gel column to yield a colorless oil.
	With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; toluene; at 0 - 20℃; for 18.0h;	A solution of <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> (0.82 g, 6.6 mmol) in toluene (30 mL,300 mmol) and methylene chloride (40 mL, 600 mmol) at 0 0C was treated with diphenylphosphonic azide (2.8 mL, 13 mmol) followed by l ,8-diazabicyclo[5.4.0]undec-7-ene (2.0 mL, 13 mmol) and stirred for 2h at 0 0C. After being further stirred at rt for 16 h, the reaction mixture was diluted with water (50 mL) and DCM (50 mL). The organic layer was separated and washed with brine, dried (Mg2SO4), filtered, and concentration. The residue was purified by column to give the product as a colorless oil. LC/MS m/e 148.0 (M-H+).
	With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In chloroform; toluene; at 0 - 15℃; for 16.0h;	To a mixture of <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> (4.1 g, 33 mmol, compound 44c) in CHC13 (40 mL) and toluene (40 mL) was added DPPA (27 g, 83 mmol) and DBU (25 g, 164 mmol) at 0 C and stirred at 15 C for 16 hrs. The reaction mixture was diluted with DCM (100 mL) and washed with water (50 mL). The separated organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to afford crude 5-(azidomethyl)-2-methylpyrimidine (2.8 g, compound 44d) as a light oil.

Reference： [1]Patent: US2008/275037,2008,A1 .Location in patent: Page/Page column 29
[2]Patent: WO2010/33168,2010,A2 .Location in patent: Page/Page column 81
[3]Patent: WO2016/180695,2016,A1 .Location in patent: Page/Page column 153

4
C₁₂H₁₉FO₂Si [ No CAS ]
[ 2239-83-0 ]
C₁₈H₂₅FN₂O₂Si [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 96.0h;	Step 1: Intermediate 30-a To a solution of intermediate 29-g (9.0 g, 37.1 mmol) and 2- (methylpyrimidin-5-yl)methanol (4.61 g, 37.1 mmol) in THF (37 ml) were sequentially added triphenylphosphine (11.69 g, 44.6 mmol) and DIAD (9.39 ml, 48.3 mmol) at room temperature and the reaction was then stirred at room temperature for 4 days. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 30- a as a yellow solid.
	With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 96.0h;	Step 1: Intermediate 30-a [0178] To a solution of intermediate 29-g (9.0 g, 37.1 mmol) and <strong>[2239-83-0]2-(methylpyrimidin-5-yl)methanol</strong> (4.61 g, 37.1 mmol) in THF (37 ml) were sequentially added triphenylphosphine (11.69 g, 44.6 mmol) and DIAD (9.39 ml, 48.3 mmol) at room temperature and the reaction was then stirred at room temperature for 4 days. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 30-a as a yellow solid.

Reference： [1]Patent: WO2013/177668,2013,A1 .Location in patent: Page/Page column 58
[2]Patent: US2015/191473,2015,A1 .Location in patent: Paragraph 0178

5
1-bromo-3-fluoro-5-iodobenzene [ No CAS ]
[ 2239-83-0 ]
C₁₂H₁₀BrFN₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In toluene; at 110℃; for 48.0h;	To a solution of 1-bromo-3-fluoro-5-iodobenzene 15-a (5.0 g, 16.62 mmol) in toluene (8.3 ml) was added <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> (2.26 g, 18.28 mmol), 1,10-phenanthroline (599 mg, 3.32 mmol), copper (I) iodide (316 mg, 1.66 mmol) and cesium carbonate (7.58 g, 23.26 mmol). The reaction was stirred at 110C for 2 days and then cooled to room temperature, diluted with ethyl acetate and filtered over celite. A saturated aqueous solution of ammonium chloride was added to the filtrate, the organic layer was separated, and the aqueous phase was extracted twice with ethyl acetate. The combined organic extracts were washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. Purification by silica gel chromatography provided intermediate 17-b as a beige solid.
	With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate;	To a solution of 1-bromo-3-fluoro-5-iodobenzene 2-a (5.0 g, 16.6 mmol) in toluene (8.3 ml) was added <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> 4-a (2.2 g, 18.3 mmol), 1,10- phenanthroline (599 mg, 3.3 mmol), copper (I) iodide (316 mg, 1.7 mmol), and cesium carbonate (7.6 g, 23.3 mmol). The reaction was stirred at 110C for 2 days, and then cooled to room temperature, diluted with ethyl acetate, and filtered over celite. A saturated aqueous solution of ammonium chloride was added to the filtrate, the organic layer was separated, and the aqueous phase was extracted twice with ethyl acetate. The combined organic extracts were washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. Purification by silica gel chromatography provided Intermediate 4-b as a beige solid.
	With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; at 110℃; for 48.0h;	To a solution of 1-bromo-3-fluoro-5-iodobenzene 2-a (5.0 g, 16.62 mmol) in toluene (8.3 ml) was added (2-methylpyrimidin-5-yI)methanol 4-a (2.26 g, 18.28 mmol), 1,10- phenanthroline (599 mg, 3.32 mmol), copper (I) iodide (316 mg, 1.66 mmol), and cesium carbonate (7.58 g, 23.26 mmol). The reaction was stirred at 11000 for 2 days, and then cooled to room temperature, diluted with ethyl acetate, and filtered over celite. A saturated aqueous solution of ammonium chloride was added to the filtrate, the organic layer was separated, and the aqueous phase was extracted twice with ethyl acetate. The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated under reduced pressure. Purification by silica gel chromatography provided Intermediate 4-b as a beige solid.

	With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In toluene; at 110℃; for 48.0h;	To a solution of 1-bromo-3-fluoro-5-iodobenzene 2-a (5.0 g, 16.62 mmol) in toluene (8.3 ml) was added <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> 4-a (2.26 g, 18.28 mmol), 1,10- phenanthroline (599 mg, 3.32 mrrol), copper (I) iodide (316 mg, 1.66 mmol), and cesium carbonate (7.58 g, 23.26 mmol). The reaction was stirred at 110C for 2 days, and then cooled to room temperature, diluted with ethyl acetate, and filtered over celite. A saturated aqueous solution of ammonium chloride was added to the filtrate, the organic layer was separated, and the aqueous phase was extracted twice with ethyl acetate. The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated under reduced pressure. Purification by silica gel chromatography provided Intermediate 4-b as a beige solid.
	With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In toluene; at 110℃; for 48.0h;	Intermediate 2-c To a solution of l-bromo-3-fluoro-5-iodobenzene 2-a (5.0 g, 16.62 mmol) in toluene (8.3 ml) was added <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> 2-b (2.3 g, 18.3 mmol), 1,10-phenanthroline (599 mg, 3.3 mmol), copper (I) iodide (316 mg, 1.6 mmol) and cesium carbonate (7.6 g, 23.3 mmol). The reaction was stirred at 110C for 2 days and then cooled to room temperature, diluted with ethyl acetate and filtered over celite. A saturated aqueous solution of ammonium chloride was added to the filtrate, the organic layer was separated, and the aqueous phase was extracted twice with ethyl acetate. The combined organic extracts were washed with brine, dried over MgS04, filtered and concentrated under reduced pressure. Purification by silica gel chromatography provided intermediate 2-c as a beige solid.

Reference： [1]Patent: WO2014/5217,2014,A1 .Location in patent: Page/Page column 33; 34
[2]Patent: WO2015/74135,2015,A1 .Location in patent: Page/Page column 35; 36
[3]Patent: WO2015/74138,2015,A1 .Location in patent: Page/Page column 37; 38
[4]Patent: WO2015/77866,2015,A1 .Location in patent: Page/Page column 38
[5]Patent: WO2016/187723,2016,A1 .Location in patent: Page/Page column 52

6
[ 2239-83-0 ]
C₂₇H₂₅FN₆O₃ [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

7
[ 2239-83-0 ]
C₂₈H₂₆FN₇O₃*2ClH [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

8
[ 2239-83-0 ]
C₂₇H₂₅FN₆O₂ [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

9
[ 2239-83-0 ]
C₂₈H₂₆FN₇O₂*2ClH [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

10
[ 2239-83-0 ]
C₂₅H₂₃FN₆O₂ [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

11
[ 2239-83-0 ]
C₂₆H₂₄FN₇O₂ [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

12
[ 2239-83-0 ]
C₂₅H₂₂F₂N₆O₂ [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

13
[ 2239-83-0 ]
C₂₆H₂₃F₂N₇O₂*2ClH [ No CAS ]

Reference： [1]Patent: WO2014/5217,2014,A1

14
[ 5194-32-1 ]
[ 2239-83-0 ]

Yield	Reaction Conditions	Operation in experiment
62.6%	With sodium tetrahydroborate; ethanol; at 20℃; for 3.0h;	Step 1 (2-methylpyrimidin-5-yl)methanol To a solution of 2-methylpyrimidine-5-carboxylic acid (150 mg, 1.23 mmOl) in ethanol (5 mL) was added sodium borohydride(93 mg, 2.46 mmol). The mixture was stirred at room temperature for 3 h. It was quenched with aqueous HC1 (2 N, 2 mL), extracted with DCM, dried over sodium sulfate, filtered and concentrated give the yellow oil product (2-methylpyrimidin-5-yl)methanol (95 mg, 62.6%). LCMS MH+ 125.
62.6%	With sodium tetrahydroborate; In ethanol; at 20℃; for 3.0h;	To a solution of 2-methylpyrimidine-5-carboxylic acid (150 mg, 1.23 mml) in ethanol (5 mL) was added sodium borohydride (93 mg, 2.46 mmol). The mixture was stirred at room temperature for 3 h. It was quenched with aqueous HCl (2 N, 2 mL), extracted with DCM, dried over sodium sulfate, filtered and concentrated give the yellow oil product (2-methylpyrimidin-5-yl)methanol (95 mg, 62.6%). LCMS MH+ 125.

Reference： [1]Patent: WO2014/143799,2014,A2 .Location in patent: Page/Page column 387
[2]Patent: US2014/275528,2014,A1 .Location in patent: Paragraph 0309; 0310

15
[ 2239-83-0 ]
[ 126504-86-7 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride; at 20℃; for 1.0h;	5-(chloromethyl)-2-methylpyrimidine A solution of <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> (95 mg, 0.77 mmol) in thionyl chloride(l was stirred at room temperature for 1 h. The mixture was concentrated to dryness and used without purification. LCMS MH+ 143.
	With thionyl chloride; at 20℃; for 1.0h;	A solution of <strong>[2239-83-0](2-methylpyrimidin-5-yl)methanol</strong> (95 mg, 0.77 mmol) in thionyl chloride (1 mL) was stirred at room temperature for 1 h. The mixture was concentrated to dryness and used without purification. LCMS MH+ 143.

Reference： [1]Patent: WO2014/143799,2014,A2 .Location in patent: Page/Page column 387
[2]Patent: US2014/275528,2014,A1 .Location in patent: Paragraph 0311; 0312
[3]Patent: WO2019/28309,2019,A1 .Location in patent: Page/Page column 36; 42

16
[ 2239-83-0 ]
1,3-dimethyl-7-((2-methylpyrimidin-5-yl)methyl)-8-(3-(trifluoromethoxy)phenoxy)-1H-purine-2,6(3H,7H)-dione [ No CAS ]

Reference： [1]Patent: US2014/275528,2014,A1

17
[ 2239-83-0 ]
C₂₆H₂₄FN₅O₂ [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

18
[ 2239-83-0 ]
C₂₇H₂₅FN₆O₂*2ClH [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

19
[ 2239-83-0 ]
C₂₈H₂₆FN₅O₂ [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

20
[ 2239-83-0 ]
C₂₉H₂₇FN₆O₂*2ClH [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

21
[ 2239-83-0 ]
C₂₈H₂₆FN₅O₃ [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

22
[ 2239-83-0 ]
C₂₉H₂₇FN₆O₃*2ClH [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

23
[ 2239-83-0 ]
C₄₄H₄₄FN₅O₃Si [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

24
[ 2239-83-0 ]
C₂₇H₂₄FN₅O₃ [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

25
[ 2239-83-0 ]
C₂₈H₂₅FN₆O₃ [ No CAS ]

Reference： [1]Patent: WO2015/74135,2015,A1

26
[ 2239-83-0 ]
C₂₈H₂₃FN₆O₃ [ No CAS ]