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Chemical Structure| 22398-09-0 Chemical Structure| 22398-09-0

Structure of 22398-09-0

Chemical Structure| 22398-09-0

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Product Details of [ 22398-09-0 ]

CAS No. :22398-09-0
Formula : C8H17N
M.W : 127.23
SMILES Code : CCCC1CCNCC1
MDL No. :MFCD00023151

Safety of [ 22398-09-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H225
Precautionary Statements:P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P310+P330+P331-P303+P361+P353+P310-P304+P340+P310-P305+P351+P338+P310-P363-P370+P378-P403+P235-P405-P501
Class:3(8)
UN#:2733
Packing Group:

Application In Synthesis of [ 22398-09-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22398-09-0 ]

[ 22398-09-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 22398-09-0 ]
  • [ 180181-02-6 ]
  • 3-amino-2,2-dimethyl-1-(4-propylpiperidin-1-yl)propan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% [0010371 Prepared using General Procedures 7 and 8 sequentially. To a stirring solution of DIEA (1.7 mL, 9.21 rnmol), 4-propylpiperidine (0.615 g, 4.83 mmol) and 3-(Qert- butoxycarbonyl)amino)-2,2-dimethylpropanoic acid (1 g, 4.60 nimol) in DMF (10 mL) was added HATU (1.925 g, 5.06 mmol). After 1 h, the mixture was poured into water (100 mL) and extracted with EA (3 x 30 niL). The combined organic extracts were washed successively with 1 M HCI (2 x 50 mL), saturated aqueous NaHCO3 (2 x 50 mL) and brine (20 niL), dried over MgSO4 and evaporated. Column chromatography (acetone/iso-hexanes) gave the protected intermediate that was dissolved in DCM (8 mL) and treated with TFA (2 mL). After 3 h, the mixture was diluted with toluene (10 mL) and solvents evaporated. The residue was dissolved in DCM (20 mL), washed with saturated aqueous NaHCO3 (50 niL), dried over Na2SO4 and solvents evaporated to afford 665 mg (64%) of 3-amino-2,2-dimethyl- 1 -(4-propylpiperidin- 1 -yl)propan- 1-one. LCMSESI (rn/z) calculated for C13H76N20: 226.2; found 227.2 [M+HT. tR = 1.31 mm (Method 11).
 

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