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Structure of Vardenafil
CAS No.: 224785-90-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction.
4.5
*For Research Use Only !
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Cardoso, Nathalie Carla ; Sohn, Jeferson Machado Batista ; Raymundi, Ana Maria ; Santos, Mateus Reis ; Prickaerts, Jos ; Gazarini, Lucas , et al.
Abstract: Fear generalization, a lack of discrimination between safe and unsafe cues, is a hallmark of posttraumatic stress disorder. The phosphodiesterase 5 (PDE5) regulates the cyclic guanosine monophosphate (cGMP) pathway, which has been proposed to be involved in fear memory generalization. However, whether PDE5 activity underlies fear memory generalization remains unexplored. Considering the importance of retrieval-induced reconsolidation in memory maintenance, we aimed to investigate whether PDE5 inhibition during reconsolidation of recent fear memory affects generalization over time in adult male Wistar rats submitted to contextual fear conditioning. The PDE5 inhibition with vardenafil (VAR) 1 mg/kg i.p. during reconsolidation triggered a time-dependent fear generalization without affecting fear memory in the paired context. Fear generalization and impaired pattern separation appear to be interlinked. Likewise, an impairment of object pattern separation was observed in the VAR-treated group at the remote time point. These effects depended on memory retrieval and were restricted to the reconsolidation time window. A chemogenetic inhibition of the anterior cingulate cortex (ACC), a region involved in allocating remote memories and generalization, prevented the effects of VAR. Moreover, VAR infusion into the ACC (6 μg/0.2 μL) after retrieval also promoted fear generalization and impaired OPS in remote time point, suggesting that ACC underlies the behavioral outcomes of the treatment with VAR. In conclusion, our results suggest that inhibiting PDE5 during the reconsolidation of a recent fear memory recruits the activity of the ACC, triggering fear memory generalization and impairing object pattern separation over time.
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Ala& ; #39 ; Y. Sirhan ; Yazan AlRashdan ; Nizam Uddin Abbasi ; Ahmad Mostafa , et al.
Abstract: A method was developed for the simultaneous determination and analysis of sildenafil, vardenafil, and tadalafil in honey-mixed herbal sachets using high-performance liquid chromatography with a UV detector (HPLC–UV). This method eliminates the employment of complex procedures and abolishes time-consuming and labour-intensive pre-treatment processes. In ten minutes, the separation process (at 25oC) of sildenafil, vardenafil, and tadalafil using a C18 150 mm × 4.6 mm x 5 μm column (Shim-pack GIST) was successful with high selectivity and sensitivity. The mobile phase was a 60:40 (v/v) mixture of 0.1 percent formic acid in water and 0.1 percent formic acid in acetonitrile. Using the mobile phase as an extraction mixture, it gave recoveries in the range of 93.0-103.3% at spike levels of 50–150 mg/kg with relative standard deviations (RSDs) lower than 10%. The intra-day and inter-day precision results were in the range of 0.4–0.8% and 1.0–1.7%. Furthermore, the retention times for sildenafil acid, vardenafil acid, and tadalafil were 1.93, 2.47, and 9.62 minutes, respectively, and the limits of detection (LOD) were 1.70, 2.16, and 1.03 mg/L, while the limits of quantification (LOQ) were 5.65, 7.21, and 3.42 mg/L.
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Keywords: HPLC ; experiment design ; sildenafil ; vardenafil ; tadalafil ; a PDE5 inhibitor
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CAS No. : | 224785-90-4 |
Formula : | C23H32N6O4S |
M.W : | 488.60 |
SMILES Code : | CCCC1=NC(C)=C2N1N=C(C(C=C(S(=O)(N3CCN(CC)CC3)=O)C=C4)=C4OCC)NC2=O |
MDL No. : | MFCD07773094 |
InChI Key : | SECKRCOLJRRGGV-UHFFFAOYSA-N |
Pubchem ID : | 135400189 |
GHS Pictogram: |
![]() ![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H301-H373-H410 |
Precautionary Statements: | P273-P301+P310 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00955929 | Penile Cancer ... More >> Erectile Dysfunction Radical Prostatectomy Less << | Not Applicable | Active, not recruiting | August 2019 | United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT02757807 | Erectile Dysfunction | Not Applicable | Unknown | December 2016 | United States, New York ... More >> RMA Recruiting New York, New York, United States, 10025 Contact: Oren Fuerst, Ph.D. oren@eco-fusion.com Less << |
NCT00906269 | Impotence Pro... More >>static Neoplasms Less << | Phase 4 | Unknown | January 2013 | United States, Connecticut ... More >> Hartford Hospital Recruiting Hartford, Connecticut, United States, 06106 Contact: James Graydon, MD 860-947-8500 jgraydo@harthosp.org Less << |
NCT01117142 | - | Recruiting | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov Less << | |
NCT00507286 | Erectile Dysfunction | Not Applicable | Unknown | December 2008 | Australia, Western Australia ... More >> Keogh Institute for Medical Research, 'A' Block 3rd Floor, QE II Medical Centre, Nedlands Perth, Western Australia, Australia, 6009 Less << |
NCT02519153 | Ureteral Stone ... More >> Urolithiasis Less << | Phase 4 | Active, not recruiting | September 2017 | - |
NCT00882934 | Impotence Ere... More >>ctile Dysfunction Less << | Not Applicable | Completed | - | - |
NCT01131104 | - | Completed | - | - | |
NCT00555087 | Erectile Dysfunction ... More >> Hypogonadotrophic Males Less << | Phase 4 | Unknown | January 2008 | Mexico ... More >> Hospital Santa Fe Not yet recruiting Mexico city, D.f., Mexico, 06700 Contact: Jorge G Jaspersen, MD-Urology (5255) 55 64 53 70 jaspersen@prodigy.net.mx Hospital General de Occidente Recruiting Guadalajara, Jalisco, Mexico, 045040 Contact: Arturo Rodriguez, MD (5235) 87 90 90 aruro2000@yahoo.com Hospital General de Occidente Not yet recruiting Guadalajara, Jalisco, Mexico, 44690 Contact: Arturo R Rodriguez, MD-Urology (5255) 333 5879 090 aruro2000@yahoo.com Hospital Universitario de Nuevo León Not yet recruiting Monterrey, Nuevo León, Mexico, 64460 Contact: Lauro G Gomez, MD.Uro-Andro (52 55 818) 20 44 44 laurogomez@hotmail.com Less << |
NCT01131104 | - | Completed | - | - | |
NCT00759174 | - | Completed | - | - | |
NCT00867815 | Anterior Ischemic Optic Neurop... More >>athy Less << | Phase 4 | Terminated | - | United States, California ... More >> Greider Eye Associates Vista, California, United States, 92083 United States, Florida Palm Beach Eye Center Atlantis, Florida, United States, 33461 West Coast Eye Care Fort Myers, Florida, United States, 33908 National Ophthalmic Research Institute Fort Myers, Florida, United States, 33912 Sarasota Retina Institute Sarasota, Florida, United States, 34239 United States, Indiana Midwest Eye Institute Indianapolis, Indiana, United States, 46290 United States, Michigan Spoor and Associates Warren, Michigan, United States, 48088 United States, North Carolina Asheville Eye Associates Asheville, North Carolina, United States, 28803 United States, Ohio Office of Dr. Avrom Epstein, MD Columbus, Ohio, United States, 43215-7312 United States, Oklahoma Tulsa Clinical Research, LLC Tulsa, Oklahoma, United States, 74014 United States, Texas Retinal and Ophthalmic Consultants Houston, Texas, United States, 77030 Australia, New South Wales Save Sight Institute Sydney, New South Wales, Australia, 2000 Canada, Ontario Midwest Eye Institute Toronto, Ontario, Canada, M5G 1X5 Less << |
NCT01063855 | Erectile Dysfunction ... More >> Sexual Dysfunction Less << | Phase 3 | Completed | - | - |
NCT01406535 | - | - | - | Austria ... More >> Rudolf Berger, MD Vienna, Austria, 1090 Less << | |
NCT03102398 | Erectile Dysfunction | Phase 1 Phase 2 | Recruiting | March 31, 2018 | Taiwan ... More >> Mackay Memorial Hospital Recruiting Taipei, Taiwan, 10449 Contact: Wei-Kung Tsai 886-2-2543-3535 Less << |
NCT00705588 | Pulmonary Arterial Hypertensio... More >>n Less << | Phase 4 | Unknown | - | Israel ... More >> Pulmonary Institute, Rabin Medical Center Not yet recruiting Petach Tikva, Israel, 49100 Sub-Investigator: Benjamin D Fox, BM BCh MRCP Less << |
NCT01063855 | - | Completed | - | - | |
NCT00678704 | Erectile Dysfunction ... More >> Diabetes Mellitus Less << | Phase 3 | Completed | - | - |
NCT00498680 | Impotence | Phase 4 | Unknown | June 2011 | Israel ... More >> Neuro-urology unit, Rambam Medical Center Recruiting Haifa, Israel, 31096 Contact: Ilan Gruenwald, MD 0097248542882 i_gruenwald@rambam.health.gov.il Contact: Yoram vardi, Prof 0097248542819 yvardi@rambam.health.gov.il Less << |
NCT00652262 | Erectile Dysfunction ... More >> Sexual Dysfunction Spinal Cord Injury Less << | Phase 3 | Completed | - | Japan ... More >> Nagoya, Aichi, Japan, 455-8530 Iizuka, Fukuoka, Japan, 820-0053 Beppu, Oita, Japan, 874-0937 Less << |
NCT00759174 | - | Completed | - | - | |
NCT00767598 | Pharmacokinetics of Three PDE5... More >>Is Healthy Subjects Genetic Polymorphic CYP3A5 Less << | Phase 1 | Completed | - | - |
NCT01084369 | Type 2 Diabetes ... More >> Hypogonadism Less << | Phase 4 | Unknown | May 2015 | United Kingdom ... More >> Tameside General Hospital Recruiting Ashton-under-Lyne, Lancashire, United Kingdom, OL6 9RW Tameside Hospital NHS Foundatoin Trust Recruiting Ashton under Lyne, United Kingdom, OL69RW Less << |
NCT00461565 | Safety | Phase 4 | Completed | - | - |
NCT00665054 | Erectile Dysfunction | Phase 4 | Completed | - | Turkey ... More >> Adana, Turkey, 01330 Ankara, Turkey, 06100 Ankara, Turkey, 06500 Antalya, Turkey, 07003 Istanbul, Turkey, 34098 Istanbul, Turkey, 34662 Izmir, Turkey, 35340 Samsun, Turkey, 55139 Less << |
NCT00668057 | Erectile Dysfunction | Phase 3 | Completed | - | China, Zhejiang ... More >> Hangzhou, Zhejiang, China, 310003 China Beijing, China, 100034 Beijing, China, 100044 Beijing, China, 100083 Beijing, China, 100853 Shanghai, China, 200040 Shanghai, China, 200127 Less << |
NCT00668096 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00654914 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT01110590 | Erectile Dysfunction | Phase 1 | Completed | - | Germany ... More >> Mönchengladbach, Nordrhein-Westfalen, Germany, 41061 Less << |
NCT00377793 | Sexual Dysfunction ... More >> Male Erectile Dysfunction Less << | Phase 4 | Completed | - | - |
NCT00379756 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00663598 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT01649739 | Pulmonary Arterial Hypertensio... More >>n Less << | Phase 4 | Unknown | January 2014 | Israel ... More >> Pulmonary Institute,Rabin Medical Center Not yet recruiting Petach Tikva, Israel, 49100 Contact: Mordechai R Kramer, MD 972-39377221 kremerm@clalit.org.il Principal Investigator: Mordechai R Kramer, MD Less << |
NCT00661219 | Erectile Dysfunction ... More >> Depression Less << | Phase 3 | Completed | - | - |
NCT00660998 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00668005 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00662441 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00874679 | - | Completed | - | China ... More >> Many Locations, China Croatia Many Locations, Croatia France Many Locations, France Germany Many Locations, Germany Hungary Many Locations, Hungary Indonesia Many Locations, Indonesia Korea, Republic of Many Locations, Korea, Republic of Malaysia Many Locations, Malaysia Poland Many Locations, Poland Saudi Arabia Many Locations, Saudi Arabia Singapore Many Locations, Singapore South Africa Many Locations, South Africa Spain Many Locations, Spain Sweden Many Locations, Sweden Thailand Many Locations, Thailand Less << | |
NCT01168817 | Erectile Dysfunction | Phase 2 | Completed | - | Finland ... More >> Oulu, Finland, 90100 Tampere, Finland, FIN-33520 Turku, Finland, 20100 France Chambery Cedex, France, 73011 Garches, France, 92380 Lille, France, 59000 Lyon Cedex, France, 69437 Nice, France, 06200 Nimes, France, 30000 Germany Weiden, Bayern, Germany, 92637 Marburg, Hessen, Germany, 35039 Osnabrück, Niedersachsen, Germany, 49076 Mülheim, Nordrhein-Westfalen, Germany, 45468 Koblenz, Rheinland-Pfalz, Germany, 56068 Leipzig, Sachsen, Germany, 04105 Leipzig, Sachsen, Germany, 04109 Hamburg, Germany, 20246 Hamburg, Germany, 20354 Italy Firenze, Italy, 50141 Milano, Italy, 20132 Napoli, Italy, 80131 Roma, Italy, 00133 Netherlands Den Haag, Netherlands, 2545 CH Groningen, Netherlands, 9713 GZ Leiden, Netherlands, 2333 ZA Spain Aravaca, Madrid, Spain, 28023 Majadahonda, Madrid, Spain, 28222 Barcelona, Spain, 08003 Barcelona, Spain, 08036 Málaga, Spain, 29007 Sweden Eskilstuna, Sweden, 633 40 Göteborg, Sweden, 405 45 Halmstad, Sweden, 302 45 Jönköping, Sweden, 554 66 Linköping, Sweden, 581 85 Stockholm, Sweden, 141 86 Less << |
NCT00461123 | Prostatic Hypertrophy, Benign | Phase 2 | Completed | - | Germany ... More >> Heidelberg, Baden-Württemberg, Germany, 69112 Less << |
NCT00657033 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00661596 | Erectile Dysfunction | Phase 3 | Completed | - | Spain ... More >> Oviedo, Asturias, Spain, 33006 Sabadell, Barcelona, Spain, 08208 Barcelona, Cataluña, Spain, 08025 Hondarribia, Guipuzcoa, Spain, 28280 Leganés, Madrid, Spain, 28911 Móstoles, Madrid, Spain, 28935 Vigo, Pontevedra, Spain, 36211 Alicante, Spain, 03010 Granada, Spain, 18003 Málaga, Spain, 29010 Sevilla, Spain, 41071 Valencia, Spain, 46014 Valladolid, Spain, 47011 Less << |
NCT00654680 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00655590 | Erectile Dysfunction | Phase 4 | Completed | - | United States, Arizona ... More >> Phoenix, Arizona, United States, 85023 Tempe, Arizona, United States, 85282 United States, California Beverly Hills, California, United States, 90212 La Mesa, California, United States, 91942-3058 Laguna Hills, California, United States, 92653 San Diego, California, United States, 92128 Torrance, California, United States, 90502-2004 Van Nuys, California, United States, 91405 United States, Connecticut Waterbury, Connecticut, United States, 06708 United States, Florida Aventura, Florida, United States, 33180 United States, Louisiana New Orleans, Louisiana, United States, 70112 United States, Michigan Ann Arbor, Michigan, United States, 48109-0330 United States, Minnesota Minneapolis, Minnesota, United States, 55455 Rochester, Minnesota, United States, 55905 United States, New York Great Neck, New York, United States, 11021 New York, New York, United States, 10016-4576 United States, Ohio Cincinnati, Ohio, United States, 45212-2787 United States, Texas San Antonio, Texas, United States, 78229 Less << |
NCT00461123 | - | Completed | - | - | |
NCT00658177 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00661115 | Erectile Dysfunction | Phase 3 | Completed | - | India ... More >> Bangalore, Karnataka, India, 560010 Bangalore, Karnataka, India, 560054 Belagum, Karnataka, India, 590010 Mumbai, Maharashtra, India, 400007 Mumbai, Maharashtra, India, 400022 Madurai, Tamilnadu, India, 625107 Less << |
NCT00667979 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00665496 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00657839 | Benign Prostatic Hyperplasia | Phase 2 | Completed | - | Germany ... More >> Biberach, Baden-Württemberg / 277, Germany, 88400 München, Bayern / 280, Germany, 81925 Rosenheim, Bayern / 280, Germany, 83022 Starnberg, Bayern / 280, Germany, 82319 Weiden, Bayern / 280, Germany, 92637 Hamburg, Hamburg / 287, Germany, 20251 Hamburg, Hamburg / 287, Germany, 20354 Marburg, Hessen / 307, Germany, 35039 Tostedt, Niedersachsen / 292, Germany, 21255 Osnabrück, Niedersachsen / 293, Germany, 49076 Düsseldorf, Nordrhein-Westfalen / 296, Germany, 40210 Leverkusen, Nordrhein-Westfalen / 331, Germany, 51373 Mülheim, Nordrhein-Westfalen / 481, Germany, 45468 Leipzig, Sachsen / 313, Germany, 04105 Kiel, Schleswig-Holstein / 306, Germany, 24105 Less << |
NCT00665340 | Erectile Dysfunction | Phase 4 | Completed | - | United States, Arizona ... More >> Phoenix, Arizona, United States, 85023 United States, California Beverly Hills, California, United States, 90212 Laguna Hills, California, United States, 92653 Newport Beach, California, United States, 92660 United States, Colorado Aurora, Colorado, United States, 80012 United States, Connecticut Trumbull, Connecticut, United States, 06611 United States, Florida Aventura, Florida, United States, 33180 United States, New Jersey Lawrenceville, New Jersey, United States, 08648 United States, New York Poughkeepsie, New York, United States, 12601 United States, North Carolina Statesville, North Carolina, United States, 28677 Wilmington, North Carolina, United States, 28401 United States, Tennessee Nashville, Tennessee, United States, 37203 Less << |
NCT00664833 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00682019 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00668109 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00663845 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00667966 | Erectile Dysfunction ... More >> Spinal Cord Injury Less << | Phase 4 | Completed | - | Spain ... More >> Badalona, Barcelona, Spain, 08916 Toledo, Spain, 45071 Less << |
NCT00909233 | - | Completed | - | Japan ... More >> Many locations, Japan Less << | |
NCT00663130 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00657644 | Erectile Dysfunction | Phase 3 | Completed | - | Russian Federation ... More >> Moscow, Russian Federation, 105425 Moscow, Russian Federation, 117198 Moscow, Russian Federation, 117837 Moscow, Russian Federation, 117997 Moscow, Russian Federation, 123367 Moscow, Russian Federation, 125101 Moscow, Russian Federation, 127206 St Petersburg, Russian Federation, 198013 Less << |
NCT00681772 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00492635 | Erectile Dysfunction ... More >> Sexual Dysfunction, Physiological Less << | Phase 3 | Completed | - | - |
NCT00656188 | Erectile Dysfunction | Phase 2 Phase 3 | Completed | - | - |
NCT00517179 | Prostatic Hyperplasia ... More >> Impotence Less << | Not Applicable | Completed | - | China ... More >> Prince of Wales Hospital Hong Kong, China Less << |
NCT00853840 | AIDS | Phase 4 | Completed | - | Belgium ... More >> Pfizer Investigational Site Bruxelles, Belgium, 1070 Less << |
NCT01207947 | - | Completed | - | Japan ... More >> Many Locations, Japan Less << | |
NCT00668135 | Erectile Dysfunction | Phase 4 | Completed | - | Hong Kong ... More >> Hong Kong, Hong Kong Indonesia Jakarta, Indonesia, 10430 Malaysia Petlaing Jaya, Salangor, Malaysia, 47500 Kuching, Sarawak, Malaysia Kuala Lumpur, Malaysia, 51200 Kuala Lumpur, Malaysia Philippines Manila, Philippines, 150 Manila, Philippines Singapore Singapore, Singapore, 119074 Singapore, Singapore, 169608 Singapore, Singapore, 529889 Thailand Bangkok, Thailand, 10700 Bangkok, Thailand Less << |
NCT00725790 | Erectile Dysfunction | Phase 4 | Unknown | September 2009 | China, Beijing ... More >> Beijing Boai Hospital Affiliated to China Rehabilitation Research Center Not yet recruiting Beijing, Beijing, China, 100077 Contact: Yan-He Ju, Dr. +86 010 87458636 jyhgjj@163.com Principal Investigator: Li-Min Liao, Dr. Less << |
NCT01106118 | - | Completed | - | Egypt ... More >> Many Locations, Egypt Israel Many Locations, Israel Kazakhstan Many Locations, Kazakhstan Korea, Republic of Many Locations, Korea, Republic of Kyrgyzstan Many Locations, Kyrgyzstan Lebanon Many Locations, Lebanon Russian Federation Many Locations, Russian Federation Saudi Arabia Many Locations, Saudi Arabia Singapore Many Locations, Singapore Ukraine Many Locations, Ukraine Less << | |
NCT00661297 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00853840 | - | Completed | - | - | |
NCT00661700 | Erectile Dysfunction | Phase 3 | Completed | - | Ireland ... More >> Dublin, Ireland, 24 United Kingdom Reading, Berkshire, United Kingdom, RG7 3SG Durham, County Durham, United Kingdom, DH1 2QW Rhyl, Denbighshire, United Kingdom, LL18 5UJ Plymouth, Devon, United Kingdom, PL4 8QU London, Greater London, United Kingdom, NW9 9NH Manchester, Greater Manchester, United Kingdom, M13 9WL Manchester, Greater Manchester, United Kingdom, M31 OUH Portsmouth, Hampshire, United Kingdom, PO3 6AD Northwood, Middlesex, United Kingdom, HA6 2RN Norwich, Norfolk, United Kingdom, NR1 3SR Belfast, Northern Ireland, United Kingdom, BT12 6BA Chipping Norton, Oxfordshire, United Kingdom, OX7 5AL Shrewsbury, Shropshire, United Kingdom, SY1 1RL Cardiff, South Glamorgan, United Kingdom, CF2 5HW Doncaster, South Yorkshire, United Kingdom, DN1 2ET Lichfield, Staffordshire, United Kingdom, WS14 9JL Glasgow, Strathclyde, United Kingdom, G21 3UW Hamilton, Strathclyde, United Kingdom, ML3 ODR Motherwell, Strathclyde, United Kingdom, ML1 3JX Coventry, Warwickshire, United Kingdom, CV6 4DD Leeds, West Yorkshire, United Kingdom, LS1 3EX Dublin, United Kingdom, 24 Less << |
NCT00478881 | Overactive Bladder ... More >> Detrusor Overactivity Less << | Phase 2 | Completed | - | - |
NCT00655629 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT02344823 | Cirrhosis Ere... More >>ctile Dysfunction Less << | Phase 4 | Unknown | - | Austria ... More >> Dept. of Internal Medicine III, Gastroenterology and Hepatology, Medical University of Vienna Recruiting Vienna, Austria, 1090 Contact: Arnulf Ferlitsch, MD +43140400 ext 47410 arnulf.ferlitsch@meduniwien.ac.at Principal Investigator: Arnulf Ferlitsch, MD Sub-Investigator: Rémy Schwarzer, MD Less << |
NCT00786253 | Erectile Dysfunction | Phase 2 | Completed | - | Germany ... More >> Tübingen, Baden-Württemberg / 277, Germany, 72076 München, Bayern / 280, Germany, 81925 Regensburg, Bayern / 280, Germany, 93053 Weiden, Bayern / 280, Germany, 92637 Berlin, Berlin / 285, Germany, 12200 Hamburg, Hamburg / 287, Germany, 20251 Hamburg, Hamburg / 287, Germany, 20354 Hamburg, Hamburg / 287, Germany, 22299 Marburg, Hessen / 307, Germany, 35039 Hagenow, Mecklenburg-Vorpommern / 309, Germany, 19230 Hannover, Niedersachsen / 291, Germany, 30625 Osnabrück, Niedersachsen / 293, Germany, 49076 Düsseldorf, Nordrhein-Westfalen / 296, Germany, 40225 Münster, Nordrhein-Westfalen / 298, Germany, 48149 Leverkusen, Nordrhein-Westfalen / 331, Germany, 51375 Grevenbroich, Nordrhein-Westfalen / 623, Germany, 41515 Leipzig, Sachsen / 313, Germany, 04249 Meißen, Sachsen / 313, Germany, 01662 Halle, Sachsen-Anhalt / 311, Germany, 06097 Less << |
NCT00478881 | - | Completed | - | - | |
NCT00666809 | Tinnitus | Phase 2 | Completed | - | Germany ... More >> Berlin, Berlin / 285, Germany, 10117 Less << |
NCT01348880 | Erectile Dysfunction | Phase 1 | Completed | - | United States, Florida ... More >> Miami, Florida, United States, 33014 United States, Tennessee Knoxville, Tennessee, United States, 37920 Less << |
NCT00668018 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT00655629 | - | Completed | - | - | |
NCT00631969 | Erectile Dysfunction | Phase 3 | Completed | - | - |
NCT01084187 | Erectile Dysfunction|Arterial ... More >>Hypertension|Endothelial Dysfunction Less << | PHASE4 | COMPLETED | 2025-02-11 | Hospital Universitário Pedro E... More >>rnesto, Rio de Janeiro, 20551030, Brazil Less << |
NCT01260285 | Ischemia-reperfusion Injury. | PHASE1 | COMPLETED | 2025-10-11 | McGuire VAMC, Richmond, Virgin... More >>ia, 23249, United States Less << |
NCT00631969 | - | Completed | - | - | |
NCT00470873 | - | Completed | - | Poland ... More >> Many locations, Poland Less << | |
NCT01002534 | Cystic Fibrosis | Phase 2 | Suspended(not yet started) | June 2012 | Belgium ... More >> Cliniques universitaires St. Luc Brussels, Belgium, 1200 Less << |
NCT00663728 | Erectile Dysfunction | Phase 4 | Completed | - | - |
NCT00718952 | Pulmonary Hypertension | Phase 3 | Completed | - | China, Beijing ... More >> Peking University First Hospital Beijing, Beijing, China, 100034 Peking University First Hospital Beijing, Beijing, China, 100043 Peking Union Hospital, Peking Union Medical College Beijing, Beijing, China, 100730 Beijing Shijitan Hospital, Peking University Beijing, Beijing, China China, Heilongjiang The First Clinical College of Harbin Medical University Harbin, Heilongjiang, China China, Hunan Xiangya Hospital, Central-South University Changsha, Hunan, China, 410008 China, Liaoning The General Hospital of Shenyang Military Command Shenyang, Liaoning, China China, Shanghai Renji Hospital, Shanghai Jiaotong University Shanghai, Shanghai, China, 200127 China, Shanxi The First Affiliated Hospital of Medical College of Xian Jiaotong University Xi'an, Shanxi, China, 710061 China Shanghai Pulmonary Hospital ,Tongji University Shanghai, China, 200433 Less << |
NCT02279992 | Glioma Brain ... More >>Neoplasms Brain Metastasis Less << | Early Phase 1 | Terminated(Unable to accrue to... More >> the study. Original PI no longer with the institute.) Less << | - | United States, California ... More >> Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 Less << |
NCT00738400 | - | Completed | - | - | |
NCT01215409 | - | Terminated(Slow recruitment) | - | Taiwan ... More >> Many Locations, Taiwan Less << | |
NCT02450188 | Erectile Dysfunction | Phase 4 | Completed | - | Italy ... More >> Ambulatori Medicina della Sessualità e Andrologia Florence, Italy Less << |
NCT01291199 | Raynaud Syndrome | Phase 2 Phase 3 | Completed | - | Germany ... More >> University of Cologne - Heart Center Cologne, NRW, Germany, 50924 Less << |
NCT02219646 | Type 2 Diabetes Mellitus (T2DM... More >>) Endothelial Dysfunction Erectile Dysfunction Less << | Phase 2 | Completed | - | Italy ... More >> Unit of Endocrinology Azienda USL Modena, Italy, 41126 Less << |
NCT00738400 | Erectile Dysfunction ... More >> Metabolic Syndrome Less << | Phase 4 | Completed | - | Germany ... More >> Cham, Bayern, Germany, 93413 Regensburg, Bayern, Germany, 93055 Frankfurt, Hessen, Germany, 60385 Marburg, Hessen, Germany, 35039 Stuhr, Niedersachsen, Germany, 28816 Bonn, Nordrhein-Westfalen, Germany, 53119 Grevenbroich, Nordrhein-Westfalen, Germany, 41515 Leverkusen, Nordrhein-Westfalen, Germany, 51373 Mülheim, Nordrhein-Westfalen, Germany, 45468 Wuppertal, Nordrhein-Westfalen, Germany, 42103 Dierdorf, Rheinland-Pfalz, Germany, 56269 Koblenz, Rheinland-Pfalz, Germany, 56068 Trier, Rheinland-Pfalz, Germany, 54290 Homburg, Saarland, Germany, 66424 Dresden, Sachsen, Germany, 01307 Leipzig, Sachsen, Germany, 04109 Berlin, Germany, 12107 Berlin, Germany, 14197 Hamburg, Germany, 20354 Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.05mL 0.41mL 0.20mL |
10.23mL 2.05mL 1.02mL |
20.47mL 4.09mL 2.05mL |
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Dissolving Methods |
in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:
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