[ CAS No. 225641-84-9 ] {[proInfo.proName]}

Name: 225641-84-9|tert-Butyl ((1R,3S)-3-hydroxycyclopentyl)carbamate|97%
Brand: Ambeed
SKU: A138207
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Quality Control of [ 225641-84-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 225641-84-9 ]

Product Details of [ 225641-84-9 ]

CAS No. :	225641-84-9	MDL No. :	MFCD18791196
Formula :	C₁₀H₁₉NO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	SBUKINULYZANSP-SFYZADRCSA-N
M.W :	201.26	Pubchem ID :	25067268
Synonyms :

Safety of [ 225641-84-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 225641-84-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 225641-84-9 ]
Downstream synthetic route of [ 225641-84-9 ]

[ 225641-84-9 ] Synthesis Path-Upstream 1~5

1
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Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 17, p. 1917 - 1920

2
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Yield	Reaction Conditions	Operation in experiment
95%	With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 14 h; Inert atmosphere	tert-butyl (1s, 4r)-4-hydroxycyclopent-2-enylcarbamate (2.0 g, 10 mmol) was dissolved in methanol (20 mL), the reaction flask was purged with nitrogen air three times. 10percent Pd/C (0.2 g, 10percent, w/w) was added to the above solution, and then replaced with hydrogen three times. The reaction solution was stirred at room temperature under hydrogen atmosphere (1 atm) for 14 hours, and filtered through celite. The filtrate was concentrated to give the title compound (1.9 g, yield: 95percent).

Reference： [1] Patent: US2016/200730, 2016, A1, . Location in patent: Paragraph 0500; 0501

3
[ 1036260-18-0 ]
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Yield	Reaction Conditions	Operation in experiment
95%	With triethylamine In dichloromethane at 0 - 20℃;	Di-tert-buty\\ dicarbonate (432 mg, 1.98 mmol) was added to a solution of (lS,3R)-3-aminocyclopentanol (200 mg, 1.98 mmol) and triethylamine (0.662 ml, 4.75 mmol) in dichloromethane (20 inL) at 0 ⁰C. After complete addition, the reaction mixture was allowed to warm up to room temperature and was stirred for 18 hours. The reaction mixture was concentrated under vacuo and purified on silica gel by flash column chromatography to give the required compound (380 mg, 95percent yield).¹H NMR (CDC13, 400 MHz) δ 1.45 (9H, s), 1.64 (IH, br d), 1.78-1.96 (4H, m), 1.96-2.1 1 (2H, m), 4.05 (IH, br s), 4.39 (IH, br s).

Reference： [1] Patent: WO2009/23269, 2009, A2, . Location in patent: Page/Page column 42

4
[ 108-05-4 ]
[ 24424-99-5 ]
[ 167465-99-8 ]
[ 225641-84-9 ]
[ 225641-82-7 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 17, p. 1917 - 1920

5
[ 99027-90-4 ]
[ 225641-84-9 ]

Reference： [1] Patent: US2016/200730, 2016, A1,