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Chemical Structure| 226710-87-8 Chemical Structure| 226710-87-8

Structure of 226710-87-8

Chemical Structure| 226710-87-8

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Product Details of [ 226710-87-8 ]

CAS No. :226710-87-8
Formula : C14H19NO3
M.W : 249.31
SMILES Code : O=C(N1CCC2=C1C=CC(O)=C2C)OC(C)(C)C

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Application In Synthesis of [ 226710-87-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 226710-87-8 ]

[ 226710-87-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 156150-67-3 ]
  • [ 226710-87-8 ]
  • tert-butyl 5-(3-chloro-4-fluorophenoxy)-4-methyl-2,3-dihydro-1H-indole-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
57.8 mg With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate; In 1,4-dioxane; at 100℃; for 3.41h; <strong>[156150-67-3]2-chloro-1-fluoro-4-iodobenzene</strong> (771) mg) In the dioxane (5 mL) solution of tert-butyl 5-hydroxy-4-methyl-2,3-dihydro-1H-indole- 1-carboxylate (500 mg), and copper iodide (I) (38.2 mg), N,N-dimethylglycine (41.4 mg) and cesium carbonate (1.31 g) were added, and it stirred at 100 degrees C for 3 hours and 25 minutes. Cerite filtration of the reaction mixture was carried out after cooling to a room temperature. The mark compound (57.8 mg) was obtained as a colorless solid by condensing under decompression of the obtained filtrate and refining residue with silica gel column chromatography (ethyl acetate/hexane).
 

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