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[ CAS No. 22923-00-8 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 22923-00-8
Chemical Structure| 22923-00-8
Structure of 22923-00-8 * Storage: {[proInfo.prStorage]}
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Product Details of [ 22923-00-8 ]

CAS No. :22923-00-8 MDL No. :
Formula : C7H5Cl2NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 190.03 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 22923-00-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22923-00-8 ]

[ 22923-00-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 141-53-7 ]
  • [ 554-00-7 ]
  • [ 22923-00-8 ]
YieldReaction ConditionsOperation in experiment
88.51% With formic acid for 12h; Reflux; 5.1.2. General procedure for preparation of N-phenylformamides (2a-e) General procedure: A mixture of sodium formate (8.1 mmol), formic acid (12.5 mL)and various substituted N-phenylformamides (40.7 mmol) was stirred at reflux for 12 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was evaporated under reduced pressure. The solid was taken up inethyl acetate to form a solution which was successively washed with water (2 20 mL) and then evaporated under reduced pressure to obtain the corresponding amides 2a-e.
78.9% In formic acid at 20℃; for 12h;
  • 2
  • [ 22923-00-8 ]
  • [ 6574-98-7 ]
YieldReaction ConditionsOperation in experiment
86.2% With triethylamine; trichlorophosphate In tetrahydrofuran at 0 - 20℃; for 1.5h;
83.51% With triethylamine; trichlorophosphate In tetrahydrofuran at 0 - 20℃; for 4h; 5.1.3. General procedure for preparation of benzonitriles (3a-e) General procedure: A solution of phosphorus oxychloride (43.0 mmol) in tetrahydrofuran(180 mL) was added drop wise to a solution of an appropriate N-phenylformamides (33.1 mmol) in tetrahydrofuran(50 mL) at 0 C. Upon the completion of addition, the ice bath has been removed, and the reaction was stirred at room temperature for 4 h and monitored by thin layer chromatography (TLC).The resulting solution was stirred at 0 C with the addition of water(250 mL) at 0 C, and then filtered to afford the corresponding benzonitriles 3a-e.
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