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Chemical Structure| 22926-86-9 Chemical Structure| 22926-86-9

Structure of 22926-86-9

Chemical Structure| 22926-86-9

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Product Details of [ 22926-86-9 ]

CAS No. :22926-86-9
Formula : C7H9N3O
M.W : 151.17
SMILES Code : N/C(C1=C(C)C=NC=C1)=N\O
MDL No. :MFCD20703179

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Application In Synthesis of [ 22926-86-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22926-86-9 ]

[ 22926-86-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7584-05-6 ]
  • [ 22926-86-9 ]
YieldReaction ConditionsOperation in experiment
47% With hydroxylamine hydrochloride; potassium hydrogencarbonate; In tetrahydrofuran; water; at -25 - 20℃; -(3-methylpyridin-4-yl)-5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)- 1,2,4-oxadiazoleHydroxylamine hydrochloride (23.53g, 339 mmol) was dissolved in water (120ml) and potassium bicarbonate (33.9g, 3339 mmol) was added cautiously. The mixture was stirred slowly until complete solution. The mixture was added to a solution of 3-methyl isonicotinonitrile (2g, 16.9 mmol) in THF (30 mL) at -25 0C (ice methanol bath) and the reaction was stirred at room temperature for 16h. The reaction mixture was extracted with EtOAc (3XlOOmL) and the combined organic phases were washed with brine (80ml). The organic phase was dried over Na2SO4 and concentrated under reduced pressure. The product was purified by column chromatography using hexanes/EtOAc (1 :1) to yield 7V-hydroxyimidamide in 47% yield (1.2 g).
 

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