7584-05-6|3-Methylisonicotinonitrile| Ambeed

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Quality Control of [ 7584-05-6 ] Purity: 98% SDS Specification

COA

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NMR

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CNMR

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Product Details of [ 7584-05-6 ]

CAS No. :	7584-05-6
Formula :	C₇H₆N₂
M.W :	118.14
SMILES Code :	CC1=C(C=CN=C1)C#N
MDL No. :	MFCD09261048
InChI Key :	SFNWPKSTEHBXSY-UHFFFAOYSA-N
Pubchem ID :	82063

Safety of [ 7584-05-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P280-P305+P351+P338-P310

Computational Chemistry of [ 7584-05-6 ] Show Less

Physicochemical Properties

Num. heavy atoms	9
Num. arom. heavy atoms	6
Fraction Csp3	0.14
Num. rotatable bonds	0
Num. H-bond acceptors	2.0
Num. H-bond donors	0.0
Molar Refractivity	33.92
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	36.68 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.44
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	0.94
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	1.26
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	0.13
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	1.78
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.11

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-1.66
Solubility	2.6 mg/ml ; 0.022 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-1.3
Solubility	5.96 mg/ml ; 0.0505 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-2.45
Solubility	0.423 mg/ml ; 0.00358 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.35 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.42

Application In Synthesis of [ 7584-05-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 7584-05-6 ]

[ 7584-05-6 ] Synthesis Path-Downstream 1~41

1
[ 1003-73-2 ]
[ 77-78-1 ]
[ 1620-77-5 ]
[ 7584-05-6 ]
[ 20970-75-6 ]

References: [1]Journal of the American Chemical Society,1959,vol. 81,p. 4004,4005.

2
[ 1003-73-2 ]
[ 74-88-4 ]
[ 7584-05-6 ]
[ 20970-75-6 ]

References: [1]Chemical and pharmaceutical bulletin,1959,vol. 7,p. 925,928.

3
[ 1681-36-3 ]
[ 7584-05-6 ]

References: [1]Pharmaceutical bulletin,1957,vol. 5,p. 78 - 79.

4
[ 7584-05-6 ]
phenylmagnesium bromide [ No CAS ]
[ 20002-31-7 ]

References: [1]Pharmaceutical bulletin,1957,vol. 5,p. 78 - 79.

5
[ 7584-05-6 ]
[ 4021-12-9 ]

References: [1]Pharmaceutical bulletin,1957,vol. 5,p. 78 - 79.

6
[ 151-50-8 ]
[ 86488-30-4 ]
[ 7584-05-6 ]
[ 20970-75-6 ]

References: [1]Chemical and pharmaceutical bulletin,1959,vol. 7,p. 925,928.

7
[ 1003-73-2 ]
[ 151-50-8 ]
[ 7584-05-6 ]

Yield	Reaction Conditions	Operation in experiment
34%		Example 1; A. 3-Methyl-isonicotinonitrile.; To 3-methyl-pyridine 1 -oxide (15.90 g, 150 mmol) is added at 0 0C during 30 min. dimethylsulfate (15.60 mL). The resulting reaction mixture is stirred overnight at 40 0C. A solution of KCN (10.75 g, 165 mmol) in a mixture of EtOH/water 1 : 1 (120 mL) is added and the reaction mixture is stirred overnight at 40 0C. The reaction mixture is concentrated in vacuo and the residue is partitioned between EtOAc and water. The aqueous phase is extracted with EtOAc and the combined organic layers are dried over Na2SO4, filtered and concentrated at reduced pressure. Purification by flash column chromatography (silica gel, cyclohexane / EtOAc 85 : 15) affords the title compound as orange crystals (6.00 g, 50.80 mmol, 34%). 1H NMR (400 MHz, DMSO-(Z6) delta ppm 8.76 (s, 1 H), 8.64 (d, J = 4.9 Hz, 1 H), 7.80 (d, J = 4.9 Hz, 1 H).
34%		3-Methyl-isonicotinonitrile; To 3-methyl-pyridine 1 -oxide (15.9 g, 150 mmol) is added at 0 0C during 30 min. dimethylsulfate (15.6 ml_). The resulting reaction mixture is stirred overnight at 40 0C. A solution of KCN (10.75 g, 165 mmol) in a mixture of EtOH / water 1 : 1 (120 mL) is added and the reaction mixture is stirred overnight at 40 0C. The reaction mixture is concentrated in vacuo and the residue is partitioned between EtOAc and water. The aqueous phase is extracted with EtOAc and the combined organic layers are dried over Na2SO4, filtered and concentrated at reduced pressure. Purification by FCC (silica gel, cyclohexane / EtOAc 85 : 15) affords the title compound as orange crystals (6.0 g, 50.8 mmol, 34%). 1H NMR (400 MHz, DMSO-d6, 298 K): delta = 8.76 (s, 1 H), 8.64 (d, J = 4.9 Hz, 1 H), 7.80 (d, J = 4.9 Hz, 1 H).
		A. A mixture of 3-methyl-pyridine 1-oxide (20 g, 0.183 mol) and iodoethane (32 mL, 0.403 mmol) is stirred 16 h. 200 mL water is added, the aqueous layer is separated and washed with Et2O. The collected aqueous layer is warmed to 50 C. and a solution of KCN (24 g, 0.366 mol) in 60 mL of water is added slowly in one hour. After an additional one hour stirring, the mixture is extracted with Et2O. The combined solvent is dried and concentrated to dryness. The residue is purified by silica gel column chromatography with hexanes:EtOAc=4:1 as eluent to provide 3-methyl-isonicotinonitrile.

References: [1]Patent: WO2008/122615,2008,A1 .Location in patent: Page/Page column 49.
[2]Patent: WO2008/122614,2008,A1 .Location in patent: Page/Page column 19.
[3]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 1349 - 1352.
[4]Journal of Heterocyclic Chemistry,1990,vol. 27,p. 1751 - 1755.
[5]Patent: US2006/116368,2006,A1 .Location in patent: Page/Page column 55.

8
[ 3230-65-7 ]
[ 7584-05-6 ]
[ 131250-24-3 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 705 - 717.

9
[ 67-56-1 ]
[ 7584-05-6 ]
3-Methyl-isonicotinimidic acid methyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 1230 - 1241.

10
[ 7584-05-6 ]
[ 917-54-4 ]
[ 82352-00-9 ]

References: [1]Journal of Heterocyclic Chemistry,1990,vol. 27,p. 1751 - 1755.

11
[ 7584-05-6 ]
[ 4637-24-5 ]
[ 80935-76-8 ]

Yield	Reaction Conditions	Operation in experiment
	In N,N-dimethyl-formamide; for 120h;	B. To a solution of <strong>[7584-05-6]3-methyl-isonicotinonitrile</strong> (12.25 g, 0.104 mmol) in 100 mL of DMF is added dimethylformamide dimethyl acetal (22 mL, 0.166 mol) portionwise in 5 days. The solvent is evaporated to dryness. The residue is purified by silica gel column chromatography with hexanes:EtOAc=4:1 as eluent to provide 3-(2-dimethylamino-vinyl)-isonicotinonitrile.

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 1349 - 1352.
[2]Patent: US2006/116368,2006,A1 .Location in patent: Page/Page column 55.

12
[ 7584-05-6 ]
[ 2365-48-2 ]
[ 116986-03-9 ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1987,vol. 329,p. 557 - 562.

13
[ 7584-05-6 ]
[ 103-63-9 ]
[ 113003-47-7 ]

References: [1]Archiv der Pharmazie,1987,vol. 320,p. 385 - 393.

14
[ 151-50-8 ]
[ 87117-12-2 ]
[ 1620-77-5 ]
[ 7584-05-6 ]
[ 20970-75-6 ]

References: [1]Heterocycles,1984,vol. 22,p. 1121 - 1124.

15
[ 222191-28-8 ]
[ 7584-05-6 ]

References: [1]Organic Preparations and Procedures International,1999,vol. 31,p. 120 - 123.
[2]Journal of Medicinal Chemistry,2017,vol. 60,p. 6942 - 6990.

Yield	Reaction Conditions	Operation in experiment
		The process in claim 63 in which the selected quaternary salt or its acid salt is of a first pyridine base from the group consisting of 4-cyanopyridine; 3-methyl-4-cyanopyridine; and 3-methylpyridine.

18
[ 151-50-8 ]
[ 86488-30-4 ]
aqueous dioxane [ No CAS ]
[ 7584-05-6 ]
[ 20970-75-6 ]

References: [1]Chemical and pharmaceutical bulletin,1959,vol. 7,p. 925,928.

19
[ 151-50-8 ]
[ 87117-12-2 ]
aqueous dioxane [ No CAS ]
[ 1620-77-5 ]
[ 7584-05-6 ]
[ 20970-75-6 ]

References: [1]Journal of the American Chemical Society,1959,vol. 81,p. 4004,4005.

20
[ 583-58-4 ]
[ 7584-05-6 ]

References: [1]Organic Preparations and Procedures International,1999,vol. 31,p. 120 - 123.
[2]Journal of Medicinal Chemistry,2012,vol. 55,p. 1682 - 1697.
[3]Russian Journal of General Chemistry,2012,vol. 82,p. 1987 - 1993.
Zh. Obshch. Khim.,2012,vol. 82,p. 2033 - 2039,7.
[4]Patent: US2014/18360,2014,A1 .
[5]Chemistry - A European Journal,2016,vol. 22,p. 8301 - 8308.
[6]Journal of Medicinal Chemistry,2017,vol. 60,p. 6942 - 6990.

21
[ 74663-96-0 ]
[ 7584-05-6 ]

References: [1]Organic Preparations and Procedures International,1999,vol. 31,p. 120 - 123.
[2]Journal of Medicinal Chemistry,2017,vol. 60,p. 6942 - 6990.

22
[ 7584-05-6 ]
[ 113003-48-8 ]

References: [1]Archiv der Pharmazie,1987,vol. 320,p. 385 - 393.

23
[ 7584-05-6 ]
1,3-Dimethyl-4-(3-phenyl)-propylpyridiniumiodid [ No CAS ]

References: [1]Archiv der Pharmazie,1987,vol. 320,p. 385 - 393.

24
[ 7584-05-6 ]
[ 113018-67-0 ]

References: [1]Archiv der Pharmazie,1987,vol. 320,p. 385 - 393.

25
[ 7584-05-6 ]
3,4-Dihydro-1',3'-dimethylspiro<naphthalin-1(2H),4'-piperidin> [ No CAS ]

References: [1]Archiv der Pharmazie,1987,vol. 320,p. 385 - 393.

26
[ 7584-05-6 ]
3,4-Dihydro-1',3'-dimethylspiro<naphthalin-1(2H),4'-piperidin> [ No CAS ]

References: [1]Archiv der Pharmazie,1987,vol. 320,p. 385 - 393.

27
[ 7584-05-6 ]
[ 117007-12-2 ]

References: [1]Journal fur praktische Chemie (Leipzig 1954),1987,vol. 329,p. 557 - 562.

28
[ 7584-05-6 ]
[ 80935-77-9 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 1349 - 1352.
[2]Bioorganic and Medicinal Chemistry,2018,vol. 26,p. 3559 - 3572.
[3]Patent: WO2009/158396,2009,A1 .

29
[ 7584-05-6 ]
[ 80935-81-5 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 1349 - 1352.
[2]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 1349 - 1352.

30
[ 7584-05-6 ]
[ 80935-78-0 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 1349 - 1352.

31
[ 7584-05-6 ]
[ 253-50-9 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 1349 - 1352.

32
[ 7584-05-6 ]
[ 83402-08-8 ]

References: [1]Journal of Heterocyclic Chemistry,1990,vol. 27,p. 1751 - 1755.

33
[ 7584-05-6 ]
[ 131895-53-9 ]

References: [1]Journal of Heterocyclic Chemistry,1990,vol. 27,p. 1751 - 1755.

34
[ 7584-05-6 ]
[ 131250-25-4 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 705 - 717.

35
[ 7584-05-6 ]
[ 131250-26-5 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 705 - 717.

36
[ 7584-05-6 ]
[ 125903-80-2 ]

References: [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 1230 - 1241.

37
[ 1003-73-2 ]
[ 7584-05-6 ]

References: [1]Chemical and pharmaceutical bulletin,1959,vol. 7,p. 925,928.

38
[ 7584-05-6 ]
[ 58997-11-8 ]

References: [1]Pharmaceutical bulletin,1957,vol. 5,p. 78 - 79.

39
[ 7584-05-6 ]
[ 106-47-8 ]
[ 698395-73-2 ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of 3-picoline (50 g, 0.48 mol) in glacial acetic acid (150 ml) was added hydrogen peroxide (25 ML) at RT. The mixture was heated to 90C for 3 hr. The mixture was cooled to RT and more hydrogen peroxide (18.5 ml) was added slowly. The mixture was again heated to 90OC for 19 hr. The excess peroxide was carefully decomposed using Pd-C (2.5 g) at 0C. Pd-C was removed by filtration, and the filtrate was concentrated and crude 3-methyl pyridine-1-oxide was purified by fractional distillation in vacuo. [00144] A solution of 3-methyl pyridine-1-oxide (10 g, 0.092 mol) in methyl iodide (15 ml) was left at rt for 18 hr and the solid was filtered. The filtrate was diluted with diethyl ether and extracted with water (40 ML). The solid was re-dissolved in the aqueous extract, 1,4-dioxane (50 ml) was added, followed by potassium cyanide (15 g, 0.23 mol) and the mixture was stirred at RT for 3 hr. The product was extracted with chloroform. The chloroform layer was washed with water, brine and dried over sodium sulfate. The solvent was removed in vacuo and the crude product was purified by fractional distillation (61-62C/0. 2 mm) to yield a white low melting solid. [00145] BC13 (24 ml, 1 M in DCM, 0.024 mol) was added slowly to a solution of 4-chloroaniline (2 g, 0.016 mol) in 30 ml of trichloroethylene over a period of 15 min. at 0C and stirred at this temperature for an additional 10 min. 4-Cyano-3-methylpyridine (2.2 g, 0.019 mol) and AIC13 (3 g, 0.022 mol) were added at 0C. The solution was allowed to warm to RT and stirred for 30 min. The solution was then heated at 80-90C for 1 hr. and the DCM was distilled off. The resulting solution was REFLUXED at 115C for 4 hr and stirred at RT overnight. 3N HCI (20 ML) was added and the mixture REFLUXED at 100C for 2 hr. The reaction mixture was cooled to 0C and adjusted to pH-12 with 6N NaOH. The reaction mixture was extracted with DCM., and the DCM layer washed with water, brine and dried over NA2SO4. The solvent was removed, and the crude was purified by column chromatography over silica gel to yield a yellow solid.

References: [1]Patent: WO2004/46092,2004,A2 .Location in patent: Page 46-47.

40
[ 931-19-1 ]
[ 7584-05-6 ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of 3-picoline (50 g, 0.48 mol) in glacial acetic acid (150 ml) was added hydrogen peroxide (25 ML) at RT. The mixture was heated to 90C for 3 hr. The mixture was cooled to RT and more hydrogen peroxide (18.5 ml) was added slowly. The mixture was again heated to 90OC for 19 hr. The excess peroxide was carefully decomposed using Pd-C (2.5 g) at 0C. Pd-C was removed by filtration, and the filtrate was concentrated and crude 3-methyl pyridine-1-oxide was purified by fractional distillation in vacuo. [00144] A solution of 3-methyl pyridine-1-oxide (10 g, 0.092 mol) in methyl iodide (15 ml) was left at rt for 18 hr and the solid was filtered. The filtrate was diluted with diethyl ether and extracted with water (40 ML). The solid was re-dissolved in the aqueous extract, 1,4-dioxane (50 ml) was added, followed by potassium cyanide (15 g, 0.23 mol) and the mixture was stirred at RT for 3 hr. The product was extracted with chloroform. The chloroform layer was washed with water, brine and dried over sodium sulfate. The solvent was removed in vacuo and the crude product was purified by fractional distillation (61-62C/0. 2 mm) to yield a white low melting solid. [00145] BC13 (24 ml, 1 M in DCM, 0.024 mol) was added slowly to a solution of 4-chloroaniline (2 g, 0.016 mol) in 30 ml of trichloroethylene over a period of 15 min. at 0C and stirred at this temperature for an additional 10 min. 4-Cyano-3-methylpyridine (2.2 g, 0.019 mol) and AIC13 (3 g, 0.022 mol) were added at 0C. The solution was allowed to warm to RT and stirred for 30 min. The solution was then heated at 80-90C for 1 hr. and the DCM was distilled off. The resulting solution was REFLUXED at 115C for 4 hr and stirred at RT overnight. 3N HCI (20 ML) was added and the mixture REFLUXED at 100C for 2 hr. The reaction mixture was cooled to 0C and adjusted to pH-12 with 6N NaOH. The reaction mixture was extracted with DCM., and the DCM layer washed with water, brine and dried over NA2SO4. The solvent was removed, and the crude was purified by column chromatography over silica gel to yield a yellow solid.

References: [1]Patent: WO2004/46092,2004,A2 .Location in patent: Page 46-47.

41
[ 7584-05-6 ]
[ 58515-46-1 ]

Yield	Reaction Conditions	Operation in experiment
	In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;	1-Amino-3-(3-methyl-4-pyridyl)2,6-naphthyridine To 5.9 g. of <strong>[7584-05-6]4-cyano-3-methylpyridine</strong> dissolved in 30 ml. of dimethylformamide, gradually add 6.7 g. of potassium t-butoxide at about 5 C. Maintain the mixture at 5 C for 4 - t hours and quench the reaction in ice water. Collect the crystalline precipitate and recrystallize from toluene to yield 1-amino-3-(3-methyl-4-pyridyl)-2,6-naphthyridine.

References: [1]Patent: US4017500,1977,A .

Historical Records

Technical Information

• Blaise Reaction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Hydride Reductions • Preparation of Aldehydes and Ketones • Preparation of Amines • Ritter Reaction • Thorpe-Ziegler Reaction

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 7584-05-6

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CAS No.: 7584-05-6

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