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Chemical Structure| 22959-34-8 Chemical Structure| 22959-34-8

Structure of 22959-34-8

Chemical Structure| 22959-34-8

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Product Details of [ 22959-34-8 ]

CAS No. :22959-34-8
Formula : C9H5ClO
M.W : 164.59
SMILES Code : C#CC(C1=CC=C(Cl)C=C1)=O
MDL No. :MFCD21262934

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Application In Synthesis of [ 22959-34-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22959-34-8 ]

[ 22959-34-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 22959-34-8 ]
  • [ 57508-48-2 ]
  • [ 31695-71-3 ]
YieldReaction ConditionsOperation in experiment
72% With sodium carbonate; In ethanol; at 150℃; for 1.5h;Microwave irradiation; General procedure: an ethanolic solution of <strong>[57508-48-2]ethyl 3-amino-3-iminopropionate hydrochloride</strong> (6*HCl; 1equiv) was pretreated with Na2CO3 (1 equiv) for 10 min. After filtering, the ethynyl ketone (1.05 equiv) was added and the mixture in EtOH (3.5 mL) was irradiated at 150 C for 1.5 h (holdtime) in a pressure-rated glass tube (10 mL) using a CEM Discover microwave synthesizer by moderation of the initial magnetron power (200 W). After cooling in a flow of compressed air,the solution was immobilized on a Biotage ISOLUTE SCX-2column and eluted with EtOH-NH4OH (aq; 35%; 5:1) or ethanolic NH3 (2 M) to give the title compound.
 

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