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[ CAS No. 23428-77-5 ]

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2D
Chemical Structure| 23428-77-5
Chemical Structure| 23428-77-5
Structure of 23428-77-5 *Storage: {[proInfo.prStorage]}

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Product Details of [ 23428-77-5 ]

CAS No. :23428-77-5MDL No. :MFCD00183289
Formula : C16H16O3 Boiling Point : 396.5±27.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :256.30Pubchem ID :307190
Synonyms :

Computed Properties of [ 23428-77-5 ]

TPSA : 35.5 H-Bond Acceptor Count : 3
XLogP3 : 3 H-Bond Donor Count : 0
SP3 : 0.19 Rotatable Bond Count : 5

Safety of [ 23428-77-5 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 23428-77-5 ]

  • Upstream synthesis route of [ 23428-77-5 ]
  • Downstream synthetic route of [ 23428-77-5 ]

[ 23428-77-5 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 6100-74-9 ]
  • [ 100-39-0 ]
  • [ 23428-77-5 ]
YieldReaction ConditionsOperation in experiment
93%
Stage #1: With potassium carbonate In acetone at 20℃; for 0.5 h;
Stage #2: for 16 h; Reflux
In 200 ml flask solanaceae of, 3-hydroxy -4 methoxyacetic aminoacetophenone of 4. 66g (28. 1mmol, 1. 0eq. ), Potassium carbonate 3. 89g (28. 1mmol, 1. 0eq. ), Containing 50 ml monohydroxyacetone, 30 minutes after stirring at room temperature, 3 a benzyl bromide. 5 ml (29. 4mmol, 1. 0eq. ) Addition, 16 back to the time. After cooling, condensing, purified water is added to 150 ml, extracted with chloroform (100 ml × 4), magnesium sulfate waterlessly org. layer by drying, filtering, concentrated, recrystallization (ethyl acetate 3 ml), suction filtration, vacuum drying, a first crystal is obtained. Concentrating somas, recrystallization (ethyl acetate 0. 5 ml), suction filtration, vacuum drying, a second crystal is obtained. The corallite crystal (compd. (IV1)), yielding: 6. 69g (26. 1mmol, 93percent)is obtained.
Reference: [1] Patent: JP2015/214531, 2015, A, . Location in patent: Paragraph 0188; 0189; 0190
[2] Bulletin of the Chemical Society of Japan, 2016, vol. 89, # 1, p. 125 - 134
[3] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 884 - 892
[4] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 3, p. 670 - 684
[5] Phytochemistry (Elsevier), 1991, vol. 30, # 7, p. 2438 - 2439
[6] Patent: EP1447405, 2004, A1, . Location in patent: Page 28-29
[7] Patent: EP1566379, 2005, A1, . Location in patent: Page/Page column 21
  • 2
  • [ 154490-49-0 ]
  • [ 23428-77-5 ]
Reference: [1] Tetrahedron, 1993, vol. 49, # 45, p. 10305 - 10316
  • 3
  • [ 621-59-0 ]
  • [ 100-44-7 ]
  • [ 23428-77-5 ]
Reference: [1] Tetrahedron, 1993, vol. 49, # 45, p. 10305 - 10316
  • 4
  • [ 1131-62-0 ]
  • [ 23428-77-5 ]
Reference: [1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982, vol. 21, # 3, p. 186 - 188
[2] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 884 - 892
[3] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 3, p. 670 - 684
  • 5
  • [ 6100-74-9 ]
  • [ 100-44-7 ]
  • [ 23428-77-5 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1959, p. 854
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982, vol. 21, # 3, p. 186 - 188
  • 6
  • [ 6346-05-0 ]
  • [ 23428-77-5 ]
Reference: [1] Tetrahedron, 1993, vol. 49, # 45, p. 10305 - 10316
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