[ CAS No. 2879-20-1 ]

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Product Details

CAS No. :2879-20-1MDL No. :MFCD00006823
Formula :C10H10O3InChI Key :HGVWMTAIIYNQSI-UHFFFAOYSA-N
M.W :178.19Pubchem ID :76143
Boiling Point :313.7°C at 760 mmHg
Synonyms :

Computed Properties

TPSA : 35.5 H-Bond Acceptor Count : 3
XLogP3 : - H-Bond Donor Count : 0
SP3 : 0.30 Rotatable Bond Count : 1

Safety

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis

[ 2879-20-1 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 7338-03-6 ]
  • [ 2879-20-1 ]
YieldReaction ConditionsOperation in experiment
82% With Dess-Martin periodane In dichloromethane at 0 - 20℃; for 16.00 h; Inert atmosphere General procedure: Method B: to a solution of compound 4a (1.65 g, 9.94 mmol) inanhydrous CH2Cl2 (100 mL) stirred at 0 C under argon was addedDess-Martin reagent (5.06 g,11.93 mmol). The mixture was allowedto warm to room temperature after 10 min and stirred for 16 h. Thereaction was quenched with a saturated sodium bicarbonate solution and salts were filtered off. The filtrate was extracted withCH2Cl2. The combined organic layers were dried over MgSO4,filtered and evaporated under reduced pressure. Purification bysilica column chromatography using CH2Cl2 as eluent gave thedesired ketone 5a (1.42 g, 87percent) as a pale yellow solid.
Reference: [1] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 80 - 105
  • 2
  • [ 493-09-4 ]
  • [ 75-36-5 ]
  • [ 2879-20-1 ]
Reference: [1] Farmaco, 1996, vol. 51, # 3, p. 215 - 217
[2] European Journal of Medicinal Chemistry, 1997, vol. 32, # 6, p. 529 - 534
[3] Tetrahedron, 2007, vol. 63, # 2, p. 474 - 491
  • 3
  • [ 1197-09-7 ]
  • [ 106-93-4 ]
  • [ 2879-20-1 ]
Reference: [1] DRP/DRBP Org.Chem., [2] Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 21, p. 693
[3] Patent: US1964973, 1932,
[4] Tetrahedron Letters, 1997, vol. 38, # 25, p. 4459 - 4462
  • 4
  • [ 493-09-4 ]
  • [ 2879-20-1 ]
Reference: [1] Journal of the Chemical Society, 1957, p. 3445
[2] Journal of the American Chemical Society, 1949, vol. 71, p. 2050,2052[3] Journal of the American Chemical Society, 1950, vol. 72, p. 3795
[4] Patent: US2383874, 1942,
  • 5
  • [ 29668-44-8 ]
  • [ 2879-20-1 ]
Reference: [1] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 80 - 105
  • 6
  • [ 493-09-4 ]
  • [ 108-24-7 ]
  • [ 2879-20-1 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 13, p. 2668 - 2674
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