Home Cart Sign in  
Chemical Structure| 23491-49-8 Chemical Structure| 23491-49-8

Structure of 23491-49-8

Chemical Structure| 23491-49-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 23491-49-8 ]

CAS No. :23491-49-8
Formula : C18H22N6
M.W : 322.41
SMILES Code : NC1=CC=C(C2=NC3=CC=C(N4CCN(C)CC4)C=C3N2)C=C1N
InChI Key :QLNHNHONCDMJOL-UHFFFAOYSA-N
Pubchem ID :11131095

Safety of [ 23491-49-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 23491-49-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 23491-49-8 ]

[ 23491-49-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 327056-62-2 ]
  • [ 23491-49-8 ]
  • [ 1339045-66-7 ]
YieldReaction ConditionsOperation in experiment
64% To 5-fluoropyridine-2-carbonitrile (200 mg, 1.64 mmol) was added a solution of sodium methoxide in methanol (0.1 M, 1.7 ml, 0.1 eq.) and the solution heated under nitrogen in a 40-45 C oil-bath for 100 min. A solution of 2 -amino-4-(5 ' -{4"- memylpiperazm- '-yl)benziniidazol-2'-yl)anilme (277 mg, 0.86 mmol) in dry methanol (15 ml) and glacial acetic acid (0.19 ml, 3.3 mmol) was then added and the mixture gently refluxed under nitrogen overnight. After cooling the solvents were removed by rotary evaporator, the residue dissolved in water (10 ml) and basified to pH 8 with dilute ammonia solution (3.0 M). After stirring for 40 min the light brown suspension was centrifuged and the supernatant removed. Then solid was then treated with water (3 5 ml), followed by acetonitrile (4 x 3 ml) with centrifuging and removal of the supernatant between treatments. The remaining solid was dried under vacuum to give a brown glassy solid (270 mg). The material was then dissolved in methanol (2 ml) and applied to a silica cartridge (KP-Sil 25g) and eluted with methanol to give 5-fluoro-2-(5'-(5"-(4'"- memylpiperazm- "-yl)benziniida as a dull light yellow powder (235 mg, 64%), mp 196-199 C. fH nmr (500 MHz, dj-MeOH + 5 drops d-TFA) δ 3.00, s, 3H, 4"'-MeN; 3.21, t (J =12.0 Hz), 2H, NCH2; 3.34, m (obs), NCH2; 3.69, d (J = 12.0 Hz), 2H, NCH2; 3.96, d ( J = 13.5 Hz), 2H, NCH2; 7.32, d ( J = 1.5 Hz), 1H, H4"; 7.41, dd (J - 2.5, 9.0 Hz), 1H, H6"; 7.73, d (J = 9.0 Hz), 1H, H7"; 7.90, ddd (J = 3.0, 8.5, 8.5 Hz), 1H, H4; 8.02, dd (J = 0.5, 8.5 Hz), 1H, H7'; 8.14, dd (J = 1.8, 8.8 Hz), 1H, H6'; 8.46, dd (J = 4.0, 8.5 Hz), 1H, H3; 8.53, dd (J = 0.5, 1.5 Hz), 1H, H4'; 8.74, d (J = 3.0 Hz), 1H, H6. 13C nmr (125 MHz, d,- MeOH + 5 drops HOAc) δ 43.6, 4"'-MeN; 49.3, C2"'/6'"; 54.6, C3"'/5'"; 102.5, C4"; 115.0, 116.3, 116.8 (overlap), C4 C6", C7 C7"; 122.9, C6'; 124.0, C5'; 124.2, d (3JCT = 5 Hz), C3; 125.0, d (2JCF = 19 Hz), C4; 134.1, C7a"; 138.8, C3a' or C3a"; 139.0, d (2JCF = 25 Hz), C6; 140.3, C3a" or C3a'; 141.5, C7a'; 145.0, C2; 148.5, C5"; 152.7, 153.1, C2 C2"; 161.4, d ('JCF = 258 Hz), C5. MS (ESI +ve) m/z 428 (MH+, 100%). HRMS (ESI +ve) m/z 428.19934, C24H23FN7 requires 428.19935 (Δ = 0.0 ppm).Cytotoxicity and radioprotection resultsC50 = 537.5PF = 40.0DMFm = 2.46DMF10 = 2.20
 

Historical Records

Categories

Similar Product of
[ 23491-49-8 ]

Chemical Structure| 1431697-77-6

A850530 [1431697-77-6]

4-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)benzene-1,2-diamine trihydrochloride

Reason: Free-salt