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A solution of l,6-naphthyridin-2(lH)-one (2 g, 13.68 mmol) in phosphoryl trichloride (20 mL) was refluxed for 16 hours. After cooling down to ambient temperature, the resulting solution was concentrated under reduced pressure and the residue was taken up by dichlorom ethane (100 mL) and washed with saturated aqueous solution of sodium bicarbonate (100 mL). The organic layer was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography, eluted with 1-2percent methanol in dichlorom ethane to afford 2-chloro-l,6-naphthyridine as a yellow solid: MS (ESI, m/z): 165.0 [M + 1]+; 1H NMR (300 MHz, DMSO-i ) δ 9.43 (s, 1H), 8.83 (d, J= 6.0 Hz, 1H), 8.69 (d, J= 11.7 Hz, 1H), 7.88 (d, J = 5.7 Hz, 1H), 7.86 (d, J= 9.6 Hz, 1H).