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Chemical Structure| 23688-07-5 Chemical Structure| 23688-07-5

Structure of 23688-07-5

Chemical Structure| 23688-07-5

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Product Details of [ 23688-07-5 ]

CAS No. :23688-07-5
Formula : C5H2Br2OS
M.W : 269.94
SMILES Code : O=CC1=C(Br)C=C(Br)S1
MDL No. :MFCD03426904

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Application In Synthesis of [ 23688-07-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 23688-07-5 ]

[ 23688-07-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3141-24-0 ]
  • [ 68-12-2 ]
  • [ 23688-07-5 ]
YieldReaction ConditionsOperation in experiment
65% 2,3,5-Tribromothiophene[12] (1.94 mL, 15.00 mmol,)was dissolved in anhydrous Et2O (50 mL) and cooled to -78oC. A solution of n-BuLi/hexane 2.5M (6 mL, 15 mmol,)was added dropwise and stirred for 1 h. DMF (18.0 mmol,1.4 mL) was then added dropwise at -78 oC, stirred for 1.5 hand allowed to warm to rt before quenching with saturatedNH4Cl (30 mL). The organic phase was separated andwashed with brine (2 × 15 mL), dried (Na2SO4) before thesolvents were removed in vacuo, and the product purified byflash chromatography using hexane/EtOAc 5:1 for elution;yield: 3.061 g (65%), yellow solid; mp. 97-99 oC. deltaH (300MHz, CDCl3): 9.81 (1H, s), 7.12 (1H, s); deltaC(75 MHz,CDCl3): 182.1, 139.0, 134.7, 152.5, 119; m/z (EI+): 272(M++4, 36%), 320 (M++2, 71), 268 (M+, 100). HRMS (EI+):Exact mass calculated for C5H2Br2OS+ 267.9675. Found267.9677.
 

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