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Heterocyclic Building Blocks
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2-(Naphthalen-2-yl)-1H-indole
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[ CAS No. 23746-81-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 23746-81-8
Chemical Structure| 23746-81-8
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Quality Control of [ 23746-81-8 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
Alternatived Products of [ 23746-81-8 ]

Product Details of [ 23746-81-8 ]

CAS No. :23746-81-8 MDL No. :MFCD00124144
Formula : C18H13N Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 243.30 Pubchem ID :-
Synonyms :

Safety of [ 23746-81-8 ]

Signal Word:Danger Class:N/A
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H315-H318-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 23746-81-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 23746-81-8 ]

[ 23746-81-8 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 1122-10-7 ]
  • [ 23746-81-8 ]
  • [ 1244766-36-6 ]
Reference： [1]Physical Chemistry Chemical Physics,2010,vol. 12,p. 9783 - 9793
  • 2
  • [ 23746-81-8 ]
  • [ 42139-37-7 ]
  • N-hydroxy-2-(4-isopropylphenyl)-2-(2-(naphthalen-2-yl)-1H-indol-3-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With polyphosphoric acid at 65 - 70℃; for 1h;
Reference： [1]Aksenov, Alexander V.; Smirnov, Alexander N.; Magedov, Igor V.; Reisenauer, Mary R.; Aksenov, Nicolai A.; Aksenova, Inna V.; Pendleton, Alexander L.; Nguyen, Gina; Johnston, Robert K.; Rubin, Michael; De Carvalho, Annelise; Kiss, Robert; Mathieu, Véronique; Lefranc, Florence; Correa, Jaime; Cavazos, David A.; Brenner, Andrew J.; Bryan, Brad A.; Rogelj, Snezna; Kornienko, Alexander; Frolova, Liliya V. [Journal of Medicinal Chemistry, 2015, vol. 58, # 5, p. 2206 - 2220]
  • 3
  • [ 62-53-3 ]
  • [ 613-54-7 ]
  • [ 23746-81-8 ]
YieldReaction ConditionsOperation in experiment
87% With N-methylimidazolium trifluoromethanesulfonate ionic liquid supported on nano-silica In neat (no solvent) at 110℃; for 0.583333h; Green chemistry; General procedure for the synthesis 2-arylindoles,2-arylimidazo[1,2-a]pyridines and 2-arylquinoxalines catalyzed by [Hmim]OTf(at)nano-SiO2 General procedure: To a mixture of aniline, 2-aminopyridine or 1,2-phenylenediamine (1 mmol) and α-bromo ketone (1 mmol), was added [Hmim]OTf(at)nano-SiO2 (0.3 mmol). The reaction mixture was stirred at 110 °C (in the case of 1,2-phenylenediamine,the reaction was performed at room temperature) for the appropriate time according to Table 2. The progressof the reaction was monitored by TLC (eluent: ethyl acetate/petroleum ether, 1:20). After completion of the reaction,ethyl acetate (10 mL) was added and the catalyst was separated by simple filtration. Evaporation of the solvent followed by purification of the crude product by column chromatography on silica gel (eluent: ethyl acetate/petroleumether, 1:20) afforded the pure product
Reference： [1]Soltani, Mohammad; Mohammadpoor-Baltork, Iraj; Khosropour, Ahmad R.; Moghadam, Majid; Tangestaninejad, Shahram; Mirkhani, Valiollah [Journal of the Iranian Chemical Society, 2015, vol. 12, # 8, p. 1369 - 1380]
  • 4
  • [ 120-72-9 ]
  • [ 39627-84-4 ]
  • [ 23746-81-8 ]
YieldReaction ConditionsOperation in experiment
66% With copper(l) iodide; oxygen; toluene-4-sulfonic acid; palladium dichloride In nitromethane; dimethyl sulfoxide at 100℃; for 10h;
Reference： [1]Liu, Congrong; Yang, Fulai [Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1213 - 1217]
  • 5
  • [ 2973-50-4 ]
  • potassium 2-naphthyltrifluoroborate [ No CAS ]
  • [ 23746-81-8 ]
Reference： [1]Organic and Biomolecular Chemistry,2017,vol. 15,p. 4300 - 4307
  • 6
  • [ 613-46-7 ]
  • [ 95-52-3 ]
  • [ 23746-81-8 ]
YieldReaction ConditionsOperation in experiment
88% With cesium fluoride; lithium hexamethyldisilazane; In 1,4-dioxane; at 110℃; for 12h;Green chemistry; General procedure: Lithium bis(trimethylsilyl)amide (66.8 mg, 0.4 mmol) and cesium fluoride (30.4 mg, 0.2 mmol) were placed in a microwave tube in a glove box. Add 0.4 mL of cyclopentyl methyl ether, Then <strong>[95-52-3]2-fluorotoluene</strong> (66 muL, 0.60 mmol) and benzonitrile (20 muL, 0.20 mmol) were added separately using a micro syringe. which was taken out from the glove box and refluxed at 110 C for 12 hours. After cooling to room temperature, the reaction was capped and three drops of water were added to quench the reaction. The solvent was removed under reduced pressure and the crude product was purified by column chromatography ( petroleum ether: ethyl acetate = 20:1) to give 2-phenylindole (34.7 mg) , 90% yield).
Reference： [1]Patent: CN109665984,2019,A .Location in patent: Paragraph 0010; 0035-0037; 0041; 0043; 0051
[2]Angewandte Chemie - International Edition,2019,vol. 58,p. 11033 - 11038
    Angew. Chem.,2019,vol. 131,p. 11149 - 11154,6
  • 7
  • [ 1538-08-5 ]
  • [ 23746-81-8 ]
  • 3,3'-(2,2,2-trifluoroethyl-1-yl)bis(2-(naphth-2-yl)-1H-indole) [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With copper(I) sulfide; di-tert-butyl peroxide; potassium tert-butylate; magnesium triflate; In 1,2-dichloro-ethane; at 120℃; for 12h;Inert atmosphere; Sealed tube; In a nitrogen-protected atmosphere, add 0.2 mmol of 2-naphthylindole to a 25mL reaction tube with a polytetrafluoroethylene magnetic stirrer.0.24 mmol of trifluoroacetylhydrazine, 0.7 mmol of potassium tert-butoxide, 0.3 mmol of di-tert-butyl peroxide (DTBP), 0.05 mmol Cu2S,0.2mmol of magnesium trifluoromethanesulfonate was finally added with 1-2mL of solvent 1,2-dichloroethane, and the reaction was stirred in a closed system at 120 C for 12 hours and then cooled to room temperature.The reaction mixture was diluted with ethyl acetate, washed with saturated NaHCO3 solution and saturated brine, and the organic phase was dried over anhydrous MgSO4, filtered and the solvent was removed by rotary evaporation, using n-pentane and ethyl acetate as eluents. 3,3'-(2,2,2-trifluoroethyl)bis(2-(naphthyl-di) -1H-indole) was isolated by silica gel column chromatography (isolated yield 91%)
Reference： [1]Patent: CN110272370,2019,A .Location in patent: Paragraph 0041; 0042

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