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[ CAS No. 2379-60-4 ]

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Chemical Structure| 2379-60-4
Chemical Structure| 2379-60-4
Structure of 2379-60-4 * Storage: {[proInfo.prStorage]}

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Alternatived Products of [ 2379-60-4 ]

Product Details of [ 2379-60-4 ]

CAS No. :2379-60-4 MDL No. :MFCD00454905
Formula : C8H3Cl2N3O2 Boiling Point : 362°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :244.03 g/mol Pubchem ID :689090
Synonyms :

Safety of [ 2379-60-4 ]

Signal Word:Danger Class:8,6.1
Precautionary Statements:P261-P280-P301+P310-P305+P351+P338 UN#:2923
Hazard Statements:H301-H315-H318-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 2379-60-4 ]

  • Downstream synthetic route of [ 2379-60-4 ]

[ 2379-60-4 ] Synthesis Path-Downstream   1~17

  • 1
  • [ 2379-60-4 ]
  • [ 100-36-7 ]
  • <i>N</i>,<i>N</i>-diethyl-<i>N</i>'-(3-chloro-6-nitro-quinoxalin-2-yl)-ethylenediamine [ No CAS ]
  • 2
  • [ 2379-60-4 ]
  • [ 100-36-7 ]
  • <i>N</i>,<i>N</i>-diethyl-<i>N</i>'-(3-chloro-7-nitro-quinoxalin-2-yl)-ethylenediamine [ No CAS ]
  • 3
  • [ 2379-56-8 ]
  • [ 2379-60-4 ]
YieldReaction ConditionsOperation in experiment
87% With thionyl chloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; for 2h;Reflux; 6-Nitroquinoxaline-2,3-(1H,4H)-dione (12 g, 59.0 mmol), thionylchloride (28.1 g, 236 mmol) and catalytic amount of dimethylformamide (0.86 g, 11.8 mmol) were dissolved in dichloroethane solvent, followed by reflux stirring for 2 hours. Upon completion of the reaction, the solvent was eliminated. The temperature was lowered to 05C. to solidify the product. The resulting solid was filtered, and dried under reduced pressure. As a result, 12.3 g of a target compound was obtained (87% yield). Mass (M+H +): 244.1 1H NMR (300 MHz, DMSO-d6): delta8.31 (d, J=9.15 Hz, 1H), 8.60 (d, J=9.15 Hz, 1H), 8.88 (s, 1H).
60% With trichlorophosphate; In N,N-dimethyl-formamide; at 90℃;Inert atmosphere; General procedure: POCl3 (75 mL, 800 mmol) was slowly added to a two-neck, 250 mL flask with 2a (16.20 g, 100 mmol) under N2, followed by DMF (15 mL, 200 mmol). The resultant solution was heated to reflux (90 C) with vigorous stirring for 8 h. After completion, the reaction was cooled to room temperature and poured into ice water. The solid obtained was filtered, washed with water and recrystallized from CH2Cl2 to give 3a as white solid (16.13 g, 81 %).
  • 4
  • [ 2379-60-4 ]
  • [ 3433-37-2 ]
  • [ 73332-40-8 ]
  • [ 73332-39-5 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In N-methyl-acetamide; dichloromethane; water; ethyl acetate; EXAMPLE 4 1,2,3,4,4a,5-Hexahydro-9-nitropyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxaline and 1,2,3,4,4a,5-hexahydro-10-nitropyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxaline A mixture of 36.6 g. of <strong>[2379-60-4]6-nitro-2,3-dichloroquinoxaline</strong>, 17.3 g. of 2-piperidinomethanol, 60 ml. of triethylamine and 500 ml. of dimethylformamide is stirred at room temperature for 4 hours, heated on a steam bath for 48 hours, diluted with 700 ml. of water and cooled overnight. The water is decanted and the residue taken up in dichloromethane, washed with water and passed through Magnesol. The filtrate is concentrated to an oil which is dissolved in 150 ml. of ethyl acetate and cooled. The resulting crystals are recovered by filtration and recrystallized from ethyl acetate giving 1,2,3,4,4a,5-hexahydro-9-nitropyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 151-154 C. The mother liquor from the first precipitation is concentrated to remove the solvent and then triturated with ether to provide a second fraction. This second fraction is boiled with the mother liquor from the first fraction providing as insoluble matter 1,2,3,4,4a,5-hexahydro-10-nitropyrido[1',2':4,5][1,4]oxazino[2,3-b]quinoxaline, m.p. 226-229 C.
  • 5
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  • [ 3433-37-2 ]
  • [ 73332-39-5 ]
  • 6
  • [ 23474-98-8 ]
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  • [ 19983-94-9 ]
  • 7
  • [ 14543-45-4 ]
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  • [ 31640-09-2 ]
  • 8
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  • [ 620-51-9 ]
  • [ 35252-30-3 ]
  • 9
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  • [ 137-97-3 ]
  • [ 35252-26-7 ]
  • 10
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  • [ 1219-84-7 ]
  • [ 35251-90-2 ]
  • 11
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  • 12
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  • [ 2646-30-2 ]
  • [ 31102-73-5 ]
  • 13
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  • [ 31102-73-5 ]
  • [ 31102-86-0 ]
  • 14
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  • [ 1516-38-7 ]
  • [ 31102-75-7 ]
  • [ 31102-88-2 ]
  • 15
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  • [ 2059-75-8 ]
  • [ 35251-92-4 ]
  • 16
  • [ 2379-60-4 ]
  • [ 2055-46-1 ]
  • [ 23120-32-3 ]
  • 17
  • [ 2379-60-4 ]
  • [ 137-07-5 ]
  • [ 19843-54-0 ]
Historical Records

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