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Chemical Structure| 23834-01-7 Chemical Structure| 23834-01-7

Structure of 23834-01-7

Chemical Structure| 23834-01-7

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Product Details of [ 23834-01-7 ]

CAS No. :23834-01-7
Formula : C9H4Cl3N
M.W : 232.49
SMILES Code : ClC1=CC2=C(C(Cl)=CC=N2)C(Cl)=C1
MDL No. :MFCD07787625

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Application In Synthesis of [ 23834-01-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 23834-01-7 ]

[ 23834-01-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 171850-29-6 ]
  • [ 23834-01-7 ]
YieldReaction ConditionsOperation in experiment
90% With trichlorophosphate; In 1,2-dichloro-ethane; at 18 - 25℃; Step 5. Add 126g of <strong>[171850-29-6]5,7-dichloro-4-hydroxyquinoline</strong> and 300g of dichloroethane to a 500mL four-necked bottle.Open the jacket to cool the water, cool down to 18 C, then add 153 g of phosphorus oxychloride at a rate of 76.5 g / h below 25 C. After the addition is completed, adjust the pH with a 30% sodium hydroxide solution at 0 C. Up to 7, followed by a rotation speed of 95 rpm at 2.5 C /Stir for 1 hour in a minute, then let stand for 10 minutes to cause delamination. Add the lower layer of material to 100 g of water, recover the dichloroethane at atmospheric pressure, precipitate the precipitate in water, and dry the precipitate at 70 C for 3 hours to obtain 4 , 5,7-trichloroquinoline. Wherein the weight of 4,5,7-trichloroquinoline is 122 g, the yield is 90%; the formula of <strong>[171850-29-6]5,7-dichloro-4-hydroxyquinoline</strong> chlorination to obtain 4,5,7-trichloroquinoline is as follows (5) is shown.
 

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