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Chemical Structure| 2388-73-0 Chemical Structure| 2388-73-0

Structure of 2388-73-0

Chemical Structure| 2388-73-0

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Product Details of [ 2388-73-0 ]

CAS No. :2388-73-0
Formula : C8H10OS
M.W : 154.23
SMILES Code : CSC1=CC=CC=C1OC
MDL No. :MFCD00792424

Safety of [ 2388-73-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 2388-73-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2388-73-0 ]

[ 2388-73-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2388-73-0 ]
  • [ 66623-79-8 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogen sulfate; bromine; In dichloromethane; EXAMPLE 206B 4-Bromo-2-methylthioanisole To a 0 C. solution of 2-methylthioanisole (0.50 g, 3.57 mmol) in methylene chloride (40 mL) was added powdered Fe (20 mg, 0.36 mmol) followed by dropwise addition of bromine (0.58 g, 3.54 mmol). After 30 minutes, the starting material had been consumed (thin layer chromatography, hexanes). The excess bromine was quenched by adding a solution of NaHSO3 and stirring for several minutes. The methylene chloride layer was separated, and the aqueous phase extracted with additional methylene chloride. The combined methylene chloride solution was dried over MgSO4, filtered, and concentrated in vacuo. The resultant oil was chromatographed (flash silica gel, ethyl acetate/hexanes 1:49) to provide the product (yield: 0.74 g, 96%). 1H NMR (300 MHz, CDCl3) δ 2.30 (s, 3H), 2.45 (s, 3H), 7.00 (d, J=8.4 Hz, 1H), 7.27-7.33 (m, 2H).
  • 2
  • [ 2388-73-0 ]
  • [ 66623-79-8 ]
  • (4-bromo-2-methoxyphenyl)(methyl)sulfane [ No CAS ]
YieldReaction ConditionsOperation in experiment
With bromine; iron; In dichloromethane; at 20℃; To a solution of 2-methylthioanisole (2 g, 13 mmol) in CH2CI2 (50 mL) was added powdered Fe (0.73 g, 1.3 mmol), followed by a dropwise addition of bromine (2.1 g, 13 mmol). After stirred at room temperature for 30 minutes, the starting material had been consumed. The excess bromine was quenched by adding a saturated aqueous solution of NaHS03 and the mixture was stirred for several minutes. The CH2CI2 layer was separated, and the aqueous phase extracted with CH2CI2. The combined CH2CI2 extracts were dried over MgS04, filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatograph using Petroleum Ether to afford a mixture of (5-bromo-2-methoxyphenyl)(methyl)sulfane and (4-bromo- 2-methoxyphenyl)(methyl)sulfane as a yellow oil. (1 .2 g, 40%). MS (ESI) m/z: 234 [M+H]+.
 

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