Product Details of [ 24484-99-9 ]
| CAS No. : | 24484-99-9 | MDL No. : | MFCD13181778 |
| Formula : |
C5H5Cl2N3
|
Boiling Point : |
- |
| Linear Structure Formula : | - | InChI Key : | N/A |
| M.W : | 178.02 | Pubchem ID : | 22336077 |
| Synonyms : |
|
Computed Properties of [ 24484-99-9 ]
| TPSA :Topological Polar Surface Area |
64.9 |
H-Bond Acceptor Count : |
3 |
| XLogP3 : |
1.4 |
H-Bond Donor Count : |
2 |
| SP3 : |
0.00 |
Rotatable Bond Count : |
0 |
Application In Synthesis of [ 24484-99-9 ]
- Upstream synthesis route of [ 24484-99-9 ]
- Downstream synthetic route of [ 24484-99-9 ]
- 1
[ 37660-64-3 ]
[ 24484-99-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 93.47% |
With hydrogenchloride; iron In water; isopropyl alcohol at 10 - 20℃; for 2.00 h; |
To a solution of 13.1 (17.5g, 84.l4mmol, 1.0 eq) in Isopropyl alcohol (525mL) was added Iron powder (23.6g, 420 mmol, 5.Oeq) and stirred. To this mixture was added 6N HC1 (7OmL) dropwise at 10°C. The reaction mixture was stirred at r.t. for 2h. After completion of reaction saturated NaHCO3 solution was added to pH 8. Reaction mixture was filtered through celite. Filtrate was extracted with ethyl acetate. Organic layers were combined, washed with brine, dried over Na2504 and concentrated in vacuo to obtain 11.2 (14g, 93.47percent). MS(ES): m/z 178 [M+H]t |
| 89% |
With iron; ammonium chloride In water; isopropyl alcohol at 70℃; for 2.00 h; |
b) 4,6-Dichloropyridine-2,3-diamine (A92) To a stirred suspension of 4,6-dichloro-3-nitropyridin-2-amine A91 (0.51 g, 2.5 mmol) in a mixture of water (11 mL) and propan-2-ol (22 mL) was added iron powder (0.68 g, 12 mmol followed by NH4CI (0.64 g, 12.2 mmol) at room temperature and the mixture was then heated to 70 °C for 2 hours. The cooled reaction mixture was filtered through celite and washed with EtOAc (150 mL). The resulting solution was washed with saturated aqueous NaHC03, brine, dried over Na2S04, filtered and evaporated under reduced pressure then dried to give the title compound as light brown crystals (0.39 g, 89percent); H NMR (400 MHz, CDCIs) 5 6.76 (s, 1 H), 4.44 (s, 2H), 3.56 (s, 2H).LCMS-A: rt 5.53 min, m/z (positive ion)178.1 [M+H]+. |
Reference：
[1] Patent: WO2018/75937, 2018, A1. Location in patent: Paragraph 00317; 00319; 00589
[2] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 102; 103
- 3
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[ 381-73-7 ]
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[ 24484-99-9 ]
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C12H11Cl2F2N3O
[ No CAS ]
- 4
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[ 24484-99-9 ]
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C26H27F3N8O3
[ No CAS ]
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[ 24484-99-9 ]
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C22H24F2N8O2
[ No CAS ]
- 6
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[ 24484-99-9 ]
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C12H13Cl2N3O
[ No CAS ]
- 7
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[ 24484-99-9 ]
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5 ,7-dichloro-2-methyl-3H-imidazo[4,5-b]pyridine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 70.49% |
With phosphorus pentoxide-methanesulfonic acid; acetic acid; at 100℃; for 4h; |
To a mixture of 98.2 (lOg, 56.lOmmol, 1.0 eq) and acetic acid (3 .7g, 61 .7lmmol, 1. leq) was added Eaton?s Reagent (4.5 mL, 4.5v) and heated at 100 °C for 4h. Upon completion, reaction mixture was cooled to r.t., neutralised with saturated NaHCO3solution and precipitated product was filtered, dried well to obtain 98.3 (8.Og, 70.49percent). MS(ES):m/z 203.2 [M+H]t |
- 8
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[ 24484-99-9 ]
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C28H32F2N6O5
[ No CAS ]
- 9
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[ 24484-99-9 ]
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C24H26ClF2N5O4
[ No CAS ]
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[ 24484-99-9 ]
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C26H28F2N8O3
[ No CAS ]
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