[ CAS No. 2455-14-3 ] {[proInfo.proName]}

Name: 2455-14-3|3,3',5,5'-Tetra-tert-butyl-[1,1'-bi(cyclohexylidene)]-2,2',5,5'-tetraene-4,4'-dione|98%
Brand: Ambeed
SKU: A124761
Price: 5.0 USD
Availability: InStock
Rating: 94 (32 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 2455-14-3

Structure of 2455-14-3 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 2455-14-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 2455-14-3 ]

SDS Specification

Alternatived Products of [ 2455-14-3 ]

Product Details of [ 2455-14-3 ]

CAS No. :	2455-14-3	MDL No. :	MFCD00051798
Formula :	C₂₈H₄₀O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	GQIGHOCYKUBBOE-UHFFFAOYSA-N
M.W :	408.62	Pubchem ID :	225283
Synonyms :

Calculated chemistry of [ 2455-14-3 ]

Physicochemical Properties

Num. heavy atoms :	30
Num. arom. heavy atoms :	0
Fraction Csp3 :	0.57
Num. rotatable bonds :	4
Num. H-bond acceptors :	2.0
Num. H-bond donors :	0.0
Molar Refractivity :	129.47
TPSA :	34.14 Å²

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	Yes
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	Yes
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-3.16 cm/s

Lipophilicity

Log Po/w (iLOGP) :	5.09
Log Po/w (XLOGP3) :	7.93
Log Po/w (WLOGP) :	7.34
Log Po/w (MLOGP) :	5.07
Log Po/w (SILICOS-IT) :	7.25
Consensus Log Po/w :	6.54

Druglikeness

Lipinski :	1.0
Ghose :	None
Veber :	0.0
Egan :	1.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-7.11
Solubility :	0.0000321 mg/ml ; 0.0000000785 mol/l
Class :	Poorly soluble
Log S (Ali) :	-8.5
Solubility :	0.0000013 mg/ml ; 0.0000000032 mol/l
Class :	Poorly soluble
Log S (SILICOS-IT) :	-6.72
Solubility :	0.0000775 mg/ml ; 0.00000019 mol/l
Class :	Poorly soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	4.98

Safety of [ 2455-14-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2455-14-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 2455-14-3 ]
Downstream synthetic route of [ 2455-14-3 ]

[ 2455-14-3 ] Synthesis Path-Upstream 1~6

1
[ 128-39-2 ]
[ 2455-14-3 ]
[ 6386-38-5 ]

Reference： [1] Journal of Chemical Research, Synopses, 1995, # 9, p. 366 - 367

2
[ 128-39-2 ]
[ 292638-85-8 ]
[ 2455-14-3 ]
[ 6386-38-5 ]

Reference： [1] Journal of Chemical Research, Synopses, 1995, # 9, p. 366 - 367
[2] Journal of Chemical Research, Synopses, 1995, # 9, p. 366 - 367

3
[ 128-39-2 ]
[ 719-22-2 ]
[ 2455-14-3 ]
[ 1139-52-2 ]

Reference： [1] Journal of Organic Chemistry, 2008, vol. 73, # 3, p. 858 - 867

4
[ 1144-36-1 ]
[ 719-22-2 ]
[ 2455-14-3 ]
[ 1139-52-2 ]

Reference： [1] Journal of Organic Chemistry, 1996, vol. 61, # 6, p. 2006 - 2012

5
[ 950-57-2 ]
[ 128-39-2 ]
[ 719-22-2 ]
[ 2455-14-3 ]
[ 40084-31-9 ]
[ 1139-52-2 ]
[ 489-01-0 ]

Reference： [1] Journal of Organic Chemistry, 1996, vol. 61, # 6, p. 2006 - 2012

6
[ 128-39-2 ]
[ 2455-14-3 ]
[ 728-40-5 ]

Reference： [1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991, vol. 40, # 10, p. 2088 - 2090[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991, # 10, p. 2381 - 2383
[3] European Journal of Organic Chemistry, 2005, # 14, p. 3052 - 3059

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 2455-14-3 ]

Alkenes

[ 17429-36-6 ]

1-Methyl-2,3-dihydro-[1,1'-biphenyl]-4(1H)-one

Similarity: 0.89

[ 36861-47-9 ]

1,7,7-Trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one

Similarity: 0.86

[ 97804-50-7 ]

(1R,4S,4aR,9aS)-rel-4a-Methyl-1,4,4a,9a-tetrahydro-1,4-methanoanthracene-9,10-dione

Similarity: 0.79

[ 99-49-0 ]

2-Methyl-5-(prop-1-en-2-yl)cyclohex-2-enone

Similarity: 0.79

[ 6485-40-1 ]

(R)-2-Methyl-5-(prop-1-en-2-yl)cyclohex-2-enone

Similarity: 0.79

Aliphatic Cyclic Hydrocarbons

[ 2460-77-7 ]

2,5-Di-tert-butylcyclohexa-2,5-diene-1,4-dione

Similarity: 0.91

[ 490-91-5 ]

2-Isopropyl-5-methylcyclohexa-2,5-diene-1,4-dione

Similarity: 0.88

[ 99-49-0 ]

2-Methyl-5-(prop-1-en-2-yl)cyclohex-2-enone

Similarity: 0.79

[ 6485-40-1 ]

(R)-2-Methyl-5-(prop-1-en-2-yl)cyclohex-2-enone

Similarity: 0.79

[ 1125-21-9 ]

2,6,6-Trimethyl-2-cyclohexene-1,4-dione

Similarity: 0.77

Ketones

[ 2460-77-7 ]

2,5-Di-tert-butylcyclohexa-2,5-diene-1,4-dione

Similarity: 0.91

[ 5447-86-9 ]

10,10-Dimethyl-9,10-dihydroanthracen-9-one

Similarity: 0.89

[ 17429-36-6 ]

1-Methyl-2,3-dihydro-[1,1'-biphenyl]-4(1H)-one

Similarity: 0.89

[ 490-91-5 ]

2-Isopropyl-5-methylcyclohexa-2,5-diene-1,4-dione

Similarity: 0.88

[ 36861-47-9 ]

1,7,7-Trimethyl-3-(4-methylbenzylidene)bicyclo[2.2.1]heptan-2-one

Similarity: 0.86

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Yield	Reaction Conditions	Operation in experiment
	With oxygen; hypochloric acid; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).

	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With dihydrogen peroxide; oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; lead dioxide; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With 2,2'-azobis(2-methylpropionamidine) dihydrochloride; oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).

Yield	Reaction Conditions	Operation in experiment
	With oxygen; hypochloric acid; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).

	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With dihydrogen peroxide; oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With oxygen; lead dioxide; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).
	With 2,2'-azobis(2-methylpropionamidine) dihydrochloride; oxygen; In hexane; at 37℃; for 1h;Product distribution / selectivity;	Table 5. Depletion of probucol or DTBP and corresponding yields of DPQ by different Ie- and 2e-oxidantsOxidant Probucol DTBPDepletion (percent) DPQ Yield (muM) Depletion (percent) DPQ Yield (muM)HOCl 98 +/-4 102+/-ll 96 +/-3 91 +/-8.7ONOO" 7+/-1 2.1 +/-0.2 6+/-1 1.9 +/-0.6H2O2 O+/-O O+/-O O+/-O O+/-OPbO2 99+/- 1.1 92 +/-21 99 +/- 0.4 145 +/-8.9Fe2VH2O2 3+/-1 8.7 +/-1.7 l+/-O 4.8 +/-3.7AAPH O+/-O O+/-O O+/-O O+/-OCu2+ 2+/-1 0.9 +/-0.1 O+/-O O+/-OCe4+ 15+/-2 78 +/- 7.9 16+/-1 89+/-11Probucol or DTBP dispersed in 2 mL hexane (final concentration 1 mM) was treated with the oxidant indicated (final concentration 5 mM) for 60 min under air and at 37 °C, the reaction mixture diluted with water (1 mL), extracted and the hexane phase analyzed as described in the Methods Section. Peroxynitrite (ONOO") was prepared, purified and standardized (s302nm -1670 M"'xm'') as described in Journal of Biological Chemistry 1991, 266:4244-4250. Abbreviations: H2O2, hydrogen peroxide; AAPH, 2,2'-azobis(2-amidino-prorhoane)-hydrochloride, and Ce4+, cerium (IV).

[ CAS No. 2455-14-3 ] {[proInfo.proName]}

Quality Control of [ 2455-14-3 ]

Related Doc. of [ 2455-14-3 ]

Product Details of [ 2455-14-3 ]