Alternatived Products of [ 246029-17-4 ]
Product Details of [ 246029-17-4 ]
CAS No. : | 246029-17-4 |
MDL No. : | MFCD14706859 |
Formula : |
C7H6F2O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
160.12
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 246029-17-4 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 246029-17-4 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 246029-17-4 ]
- 1
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[ 203059-80-7 ]
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[ 246029-17-4 ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium thiomethoxide In N,N-dimethyl-formamide at 20℃; for 2h; |
5
Preparation 54,5-DIFLUORO-2-METHOXYPHENOLTo a solution of 1 ,2-difluoro-4,5-dimethoxybenzene (5 g, 28.7 mmol) in DMF (14 ml) was added sodium thiomethoxide (6.2 g, 88.5 mmol). After 30 min more DMF (4 ml) was added. The mixture was stirred in room temperature for 1 h 30 min and cooled on an icebath. Water was added and then HCI (10% in H2O). The solution was extracted with EtOAc and the combined organic phases were washed with water, dried (MgSO4) and evaporated to dryness with EtOH. Purification on flash column chromatography (Isooctane/EtOAc) gave the title compound (1.5 g). MS m/z (rel. intensity, 70 eV) 160 (M+, 82) 145 (bp), 117 (63), 97 (8), 88 (9). |
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Stage #1: 1,2-difluoro-4,5-dimethoxybenzene With sodium thiomethoxide In N,N-dimethyl-formamide at 100℃; for 6h;
Stage #2: In ethyl acetate |
28.i
Sodium thiomethoxide (0.4g) was added to a solution of 1, 2-difluoro-4,5- dimethoxybenzene (1. OG) in DMF (LOML) at RT, then heated at 100°C for 4h. A further 0. 8G of sodium thiomethoxide was added, the mixture heated for a further 2H. The mixture was cooled, partitioned between ethylacetate/2M hydrochloric acid, the organics dried and evaporated under reduced pressure, yield 1. 05g |