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Chemical Structure| 246240-10-8 Chemical Structure| 246240-10-8

Structure of 246240-10-8

Chemical Structure| 246240-10-8

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Product Details of [ 246240-10-8 ]

CAS No. :246240-10-8
Formula : C13H20N2O3
M.W : 252.31
SMILES Code : O=C(OC(C)(C)C)NCCOC1=CC=CC(N)=C1
MDL No. :MFCD11922407

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 246240-10-8 ]

[ 246240-10-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 591-27-5 ]
  • [ 158690-56-3 ]
  • [ 246240-10-8 ]
YieldReaction ConditionsOperation in experiment
58% With caesium carbonate; In N,N-dimethyl-formamide; at 20℃; for 15h;Inert atmosphere; Step 1: A mixture of 1-aminophenol (1) (207 mg, 1.9 mmol), 2-(fert-butoxycarbonylamino)ethyl 4- methylbenzenesulfonate (2) (500 mg, 1.9 mmol), and cesium carbonate (770 mg, 2.2 mmol) in DMF (6 ml) was stirred at room temperature under argon for 15 hours. The mixture was concentrated under reduced pressure. The residue was partitioned between EtOAc and water. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash chromatography (40 to 60% EtOAc -hexanes gradient) gave tert-buty 2-(3- aminophenoxy)ethylcarbamate (3) as colorless oil. Yield (220 mg, 58%). 1H NMR (400 MHz, DMSO-J6) δ 6.92 (t, J = 5.2 Hz, IH), 6.85 (t, J = 8.0 Hz, IH), 6.08-6.12 (m, 2H), 6.02-6.04 (m, IH), 4.99 (bs, 2H), 3.79 (t, J= 6.0 Hz, 2H), 3.21 (q, J= 6.0 Hz, 2H), 1.36 (s, 9H).
 

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