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[ CAS No. 2463-16-3 ]

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2D
Chemical Structure| 2463-16-3
Chemical Structure| 2463-16-3
Structure of 2463-16-3 *Storage: {[proInfo.prStorage]}

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Product Details of [ 2463-16-3 ]

CAS No. :2463-16-3MDL No. :MFCD03086010
Formula : C10H9NO2 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :175.18Pubchem ID :13026687
Synonyms :

Computed Properties of [ 2463-16-3 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 2463-16-3 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P280-P305+P351+P338UN#:N/A
Hazard Statements:H317-H319Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 2463-16-3 ]

  • Upstream synthesis route of [ 2463-16-3 ]
  • Downstream synthetic route of [ 2463-16-3 ]

[ 2463-16-3 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 64-17-5 ]
  • [ 24964-64-5 ]
  • [ 2463-16-3 ]
YieldReaction ConditionsOperation in experiment
65% With potassium carbonate In water at 20℃; for 5 h; General procedure: A mixture of bromine chloride resin and K2CO3 in MeOH–H2O (8:2) 3 mL was placed in a round-bottom flask fitted with amagnetic stirrer. To this, the aldehyde (1 mmol, 1 equiv) was added dropwise, and the reaction mixture stirred at r.t. The progress of the reaction was monitored by TLC. After completionof the reaction the mixture was filtered, and the filtrate was extracted with Et2O. The ether layer was washed with H2O, brine, dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography, if required, over silicagel (60–120 mesh) using a mixture of PE and EtOAc (9:1) as eluent.
Reference: [1] Synlett, 2016, vol. 27, # 9, p. 1344 - 1348
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 6, p. 2070 - 2072
  • 2
  • [ 6952-59-6 ]
  • [ 1906-57-6 ]
  • [ 2463-16-3 ]
YieldReaction ConditionsOperation in experiment
70% With palladium diacetate In 1-methyl-pyrrolidin-2-one at 20 - 140℃; for 24 h; Inert atmosphere General procedure: An oven-dried Schlenk-tube (10 mL) was charged with Pd source (1 mol percent), and ethyl potassium oxalate (0.75 mmol). The tube was evacuated and backfilled with argon (this procedure was repeated three times). After that, iodobenzene (0.5 mmol) and NMP (1.0 mL) were added by syringe under a counter flow of argon at room temperature. The reaction vessel was closed and then placed under stirring in a preheated oil bath. The reaction mixture was stirred for 24 h. Upon completion of the reaction, the mixture was cooled to room temperature and diluted with ethyl acetate, and analyzed by gas chromatography.
Reference: [1] Tetrahedron Letters, 2012, vol. 53, # 43, p. 5796 - 5799
  • 3
  • [ 557-21-1 ]
  • [ 1070663-96-5 ]
  • [ 2463-16-3 ]
Reference: [1] Journal of Organic Chemistry, 2018,
  • 4
  • [ 58313-23-8 ]
  • [ 2463-16-3 ]
Reference: [1] New Journal of Chemistry, 2012, vol. 36, # 11, p. 2334 - 2339
  • 5
  • [ 64-17-5 ]
  • [ 1877-72-1 ]
  • [ 2463-16-3 ]
Reference: [1] Angewandte Chemie - International Edition, 2014, vol. 53, # 30, p. 7928 - 7932[2] Angew. Chem., 2014, vol. 126, # 30, p. 8062 - 8066,5
  • 6
  • [ 24398-88-7 ]
  • [ 2463-16-3 ]
Reference: [1] Organic and Biomolecular Chemistry, 2015, vol. 13, # 9, p. 2541 - 2545
  • 7
  • [ 99-05-8 ]
  • [ 2463-16-3 ]
Reference: [1] Chemische Berichte, 1886, vol. 19, p. 1494
  • 8
  • [ 618-98-4 ]
  • [ 2463-16-3 ]
Reference: [1] Chemische Berichte, 1938, vol. 71, p. 335,338
  • 9
  • [ 582-33-2 ]
  • [ 2463-16-3 ]
Reference: [1] Chemische Berichte, 1886, vol. 19, p. 1494
[2] Chemische Berichte, 1938, vol. 71, p. 335,338
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