Home Cart 0 Sign in  

[ CAS No. 247133-22-8 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 247133-22-8
Chemical Structure| 247133-22-8
Structure of 247133-22-8 *Storage: {[proInfo.prStorage]}

Quality Control of [ 247133-22-8 ]

Related Doc. of [ 247133-22-8 ]

SDS
Alternatived Products of [ 247133-22-8 ]
Alternatived Products of [ 247133-22-8 ]

Product Details of [ 247133-22-8 ]

CAS No. :247133-22-8MDL No. :MFCD08236791
Formula : C11H15NO Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :177.24Pubchem ID :-
Synonyms :

Computed Properties of [ 247133-22-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 247133-22-8 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P280-P305+P351+P338UN#:N/A
Hazard Statements:H302Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 247133-22-8 ]

  • Downstream synthetic route of [ 247133-22-8 ]

[ 247133-22-8 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 341548-14-9 ]
  • [ 247133-22-8 ]
YieldReaction ConditionsOperation in experiment
93% With sodium hydroxide In ethanol; water for 1h; Heating;
  • 2
  • [ 22246-71-5 ]
  • [ 247133-22-8 ]
YieldReaction ConditionsOperation in experiment
With lithium aluminium tetrahydride In tetrahydrofuran; 1,4-dioxane for 20h; Heating;
With sodium hydroxide In tetrahydrofuran; 1,4-dioxane 41.2 8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine Step 2 8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine To a solution of lithium aluminum hydride (3.07 g) in tetrahydrofuran (60 ml) was dropwise added a solution of 8-methoxy-2,3,4,5-tetrahydrobenz[c]azepin-1-one (4.42 g) in 1,4-dioxane (30 ml) with ice-cooling and the mixture was refluxed for 20 hours. After completion of the reaction, 20% aqueous sodium hydroxide solution was added dropwise with ice-cooling, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was filtrated, and the solvent was evaporated and the residue was dried under reduced pressure to give the title compound (4.05 g). 1H-NMR (δ ppm, CDCl3) 1.68 (m, 2H), 2.82-2.90 (m, 2H), 3.10-3.25 (m, 2H), 3.77 (s, 3H), 3.88 (s, 2H), 6.60-6.70 (2H), 7.05 (1H).
With lithium aluminium tetrahydride In tetrahydrofuran at 20 - 80℃; for 1.5h; Heating / reflux; 81.2 8-methoxy-2,3,4,5-tetrahydro-benzo[C]-azepin-l-one (0.512 g, 2.68 mmol) was stirred in anhydrous tetrahydrofiiran (13.4 mL) at room temperature under nitrogen. A solution of lithium aluminum hydride in tetrahydrofiiran (IM, 4.02 mL) was added dropwise via syringe to the clear solution. The resulting reaction mixture was refluxed at 8O0C for 1.5 hours. The reaction was cooled to room temperature and then brought to O0C with an ice bath. This was quenched by slow addition of saturated potassium sodium tartrate. The biphase was stirred at room temperature for 30 minutes and extracted with ethyl acetate (2x). The combined organic layers were washed with water, brine, dried over sodium sulfate, filtered and concentrated in vacuo to yield the title compound as a clear oil.
  • 3
  • [ 247133-22-8 ]
  • 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogen bromide for 2h; Heating;
In aqueous hydrogen bromide; diethyl ether; ethanol 41.3 8-Hydroxy-2,3,4,5-tetrahydro-1H-benz[c]azepine Hydrobromide Step 3 8-Hydroxy-2,3,4,5-tetrahydro-1H-benz[c]azepine Hydrobromide 8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine (3.65 g) was dissolved in 48% aqueous hydrogen bromide solution (36 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and ethanol and diethyl ether were added to the obtained residue. The mixture was filtrated and dried under reduced pressure to give the title compound (4.56 g). 1H-NMR (δ ppm, DMSO-d6) 1.80-1.83 (m, 2H), 2.85-2.88 (m, 2H), 3.22 (m, 2H), 4.20-4.22 (m, 2H), 6.69 (dd, J=2.5, 8.1 Hz, 1H), 6.82 (d, J=2.5 Hz, 1H), 7.05 (d, J=8.1 Hz, 1H), 8.80 (brs, 2H), 9.42 (brs, 1H).
  • 4
  • [ 247133-22-8 ]
  • [ 247133-24-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: aq. HBr / 2 h / Heating 2: aq. NaOH / dioxane / 12 h / 20 °C
  • 5
  • [ 247133-22-8 ]
  • [ 247133-25-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: aq. HBr / 2 h / Heating 2.1: aq. NaOH / dioxane / 12 h / 20 °C 3.1: NaH / dimethylformamide / 0.5 h / 0 °C 3.2: dimethylformamide / 12 h / 20 °C
  • 6
  • [ 247133-22-8 ]
  • [ 854261-82-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: aq. HBr / 2 h / Heating 2.1: aq. NaOH / dioxane / 12 h / 20 °C 3.1: NaH / dimethylformamide / 0.5 h / 0 °C 3.2: dimethylformamide / 12 h / 20 °C 4.1: SO2Cl2 / CH2Cl2 / 1 h / 0 °C
Historical Records

Related Functional Groups of
[ 247133-22-8 ]

Ethers

Chemical Structure| 42923-77-3

[ 42923-77-3 ]

6-Methoxy-1,2,3,4-tetrahydroisoquinoline

Similarity: 0.91

Chemical Structure| 43207-78-9

[ 43207-78-9 ]

7-Methoxy-1,2,3,4-tetrahydroisoquinoline

Similarity: 0.91

Chemical Structure| 57196-62-0

[ 57196-62-0 ]

6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Similarity: 0.89

Chemical Structure| 1823523-01-8

[ 1823523-01-8 ]

2-Benzyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Similarity: 0.89

Chemical Structure| 54893-23-1

[ 54893-23-1 ]

7-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

Similarity: 0.89

Related Parent Nucleus of
[ 247133-22-8 ]

Other Aromatic Heterocycles

Chemical Structure| 667398-64-3

[ 667398-64-3 ]

2,3,4,5-Tetrahydro-1H-benzo[c]azepin-7-ol hydrobromide

Similarity: 0.89

Chemical Structure| 374813-35-1

[ 374813-35-1 ]

2,3,4,5-Tetrahydro-1H-benzo[c]azepin-8-ol hydrobromide

Similarity: 0.89

Chemical Structure| 113853-92-2

[ 113853-92-2 ]

2,3,4,5-Tetrahydro-1H-benzo[c]azepine-7,8-diol hydrobromide

Similarity: 0.85

Chemical Structure| 50351-80-9

[ 50351-80-9 ]

7-Methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Similarity: 0.84

Chemical Structure| 76208-70-3

[ 76208-70-3 ]

7-Methoxy-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Similarity: 0.83