[ CAS No. 2492-23-1 ] {[proInfo.proName]}

Name: 2492-23-1|(2,4-Dichlorobenzyl)triphenylphosphonium chloride|98%
Brand: Ambeed
SKU: A179615
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Quality Control of [ 2492-23-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 2492-23-1 ]

SDS Specification

Alternatived Products of [ 2492-23-1 ]

Product Details of [ 2492-23-1 ]

CAS No. :	2492-23-1	MDL No. :	MFCD00031641
Formula :	C₂₅H₂₀Cl₃P	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	FWBSWSPGFNAXPP-UHFFFAOYSA-M
M.W :	457.76	Pubchem ID :	196999
Synonyms :

Safety of [ 2492-23-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 2492-23-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 2492-23-1 ]
Downstream synthetic route of [ 2492-23-1 ]

[ 2492-23-1 ] Synthesis Path-Upstream 1~1

1
[ 94-99-5 ]
[ 603-35-0 ]
[ 2492-23-1 ]

Reference： [1] Journal of Heterocyclic Chemistry, 1996, vol. 33, # 3, p. 671 - 673
[2] Medicinal Chemistry Research, 2011, vol. 20, # 8, p. 1158 - 1163

[ 2492-23-1 ] Synthesis Path-Downstream 1~34

1
[ 1734-79-8 ]
[ 2492-23-1 ]
[ 15866-68-9 ]

Reference： [1]Journal of Pharmaceutical Sciences,1967,vol. 56,p. 737 - 742

2
[ 1504-76-3 ]
[ 2492-23-1 ]
[ 15866-65-6 ]

Reference： [1]Journal of Pharmaceutical Sciences,1967,vol. 56,p. 737 - 742

3
[ 641-57-6 ]
[ 2492-23-1 ]
[ 60824-75-1 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1976,p. 1415 - 1420

4
[ 33535-80-7 ]
[ 2492-23-1 ]
[ 60824-78-4 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1976,p. 1415 - 1420

5
[ 2492-23-1 ]
[ 479-33-4 ]
[ 60824-71-7 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1976,p. 1415 - 1420

6
[ 4613-68-7 ]
[ 2492-23-1 ]
[ 101910-00-3 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 4995 - 4996

7
[ 141317-08-0 ]
[ 108-24-7 ]
[ 2492-23-1 ]
[ 141240-05-3 ]
[ 141240-05-3 ]

Reference： [1]Carbohydrate Research,1992,vol. 225,p. 247 - 267

8
[ 2492-23-1 ]
[ 149007-64-7 ]
(2R,4R,5S,6S)-4-[(Z)-2-(2,4-Dichloro-phenyl)-vinyl]-6-hydroxymethyl-2-(4-methoxy-phenyl)-[1,3]dioxan-5-ol [ No CAS ]

Reference： [1]Carbohydrate Research,1993,vol. 239,p. 117 - 132

9
[ 2492-23-1 ]
(2R,4R,5R,6R)-5-Hydroxy-6-hydroxymethyl-2-phenyl-[1,3]dioxane-4-carbaldehyde [ No CAS ]
(2S,4S,5S,6R)-4-[(Z)-2-(2,4-Dichloro-phenyl)-vinyl]-6-hydroxymethyl-2-phenyl-[1,3]dioxan-5-ol [ No CAS ]

Reference： [1]Carbohydrate Research,1994,vol. 257,p. 217 - 226

10
[ 2492-23-1 ]
[ 81577-69-7 ]
(Z)-2-O-acetyl-1,3-O-benzylidene-4,5-dideoxy-5-C-(2,4-dichlorophenyl)-L-erythro-pent-4-enitol [ No CAS ]

Reference： [1]Carbohydrate Research,1994,vol. 257,p. 217 - 226

11
[ 3274-12-2 ]
[ 2492-23-1 ]
[ 19671-08-0 ]

Reference： [1]Journal of Organic Chemistry,1962,vol. 27,p. 1057 - 1058

12
[ 2492-23-1 ]
[ 107496-65-1 ]
(E)-2,3-bis(2,4-dichlorophenyl)prop-2-en-1-yl acetate [ No CAS ]
(Z)-2,3-bis(2,4-dichlorophenyl)prop-2-en-1-yl acetate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 1877 - 1880

13
[ 94-99-5 ]
[ 603-35-0 ]
[ 2492-23-1 ]

Reference： [1]Journal of Heterocyclic Chemistry,1996,vol. 33,p. 671 - 673
[2]Medicinal Chemistry Research,2011,vol. 20,p. 1158 - 1163

14
[ 2492-23-1 ]
[ 13750-81-7 ]
[ 181486-45-3 ]

Reference： [1]Journal of Heterocyclic Chemistry,1996,vol. 33,p. 671 - 673

15
[ 2492-23-1 ]
2-[2-(2,4-dichlorophenyl)ethyl]-1-methylimidazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1996,vol. 33,p. 671 - 673

16
[ 2492-23-1 ]
(Z)-1,3-di-O-acetyl-2,4-O-benzylidene-5,6-dideoxy-6-C-(2,4-dichlorophenyl)-L-ribo-hex-5-enitol [ No CAS ]

Reference： [1]Carbohydrate Research,1994,vol. 257,p. 217 - 226

17
[ 2492-23-1 ]
(Z)-1,3-di-O-acetyl-5,6-dideoxy-6-C-(2,4-dichlorophenyl)-2,4-O-methoxybenzylidene-D-xylo-hex-5-enitol [ No CAS ]

Reference： [1]Carbohydrate Research,1993,vol. 239,p. 117 - 132

18
[ 2492-23-1 ]
(E)-1,3-di-O-acetyl-5,6-dideoxy-6-C-(2,4-dichlorophenyl)-2,4-O-methoxybenzylidene-D-xylo-hex-5-enitol [ No CAS ]

Reference： [1]Carbohydrate Research,1993,vol. 239,p. 117 - 132

19
[ 2492-23-1 ]
[ 101910-02-5 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 4995 - 4996

20
[ 2492-23-1 ]
[ 90691-50-2 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 4995 - 4996

21
[ 2492-23-1 ]
[ 101910-01-4 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 4995 - 4996

22
[ 2492-23-1 ]
[ 101910-04-7 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 4995 - 4996

23
[ 2492-23-1 ]
[ 90761-31-2 ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 4995 - 4996

24
[ 2492-23-1 ]
1-(m-Aminophenyl)-4-(2.4-dichlorphenyl)-butan [ No CAS ]

Reference： [1]Journal of Pharmaceutical Sciences,1967,vol. 56,p. 737 - 742

25
[ 2492-23-1 ]
1-(p-Aminophenyl)-4-(2.4-dichlorphenyl)-butan [ No CAS ]

Reference： [1]Journal of Pharmaceutical Sciences,1967,vol. 56,p. 737 - 742

26
2,4-dichloro-omega-(imidazolyl-1)-acetophenone [ No CAS ]
[ 2492-23-1 ]
1,2-bis(2,4-dichlorophenyl)-3-(imidazolyl-1 l)-propene-1-nitrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium; In methanol; ethyl acetate;	EXAMPLE 1 4 g of <strong>[2492-23-1]2,4-dichlorobenzyl triphenyl phosphonium chloride</strong> and 2.2 g of 2,4-dichloro-omega-(imidazolyl-1)-acetophenone are dissolved in 100 ml of methanol. A solution of 0.2 g of sodium in 10 ml of methanol is then added and the whole boiled under reflux for 2 hours. After the solvent has been distilled off, the residue is dissolved in ethylacetate and freed from undissolved sodium chloride by filtration. 3.1 g (74 % of the theoretical) of a cis-trans-isomer mixture of 1,2-bis(2,4-dichlorophenyl)-3-(imidazolyl-1 l)-propene-1-nitrate melting at 145-152 C are obtained from the ethylacetate solution by the gradual addition of a slight excess of 100 % nitric acid.

Reference： [1]Patent: US4057545,1977,A

27
4-bromo-omega-(imidazolyl-1)-acetophenone [ No CAS ]
[ 2492-23-1 ]
trans-1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-3-(imidazolyl-1)-propene-1-nitrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran; hexane; ethyl acetate;	EXAMPLE 2 3 g of lithium butyl (20 % in hexane) are added to 4 g of <strong>[2492-23-1]2,4-dichlorobenzyl triphenyl phosphonium chloride</strong> in 100 ml of absolute tetrahydrofuran. After stirring for 3 hours at room temperature, 2.3 g of 4-bromo-omega-(imidazolyl-1)-acetophenone in 50 ml of tetrahydrofuran are added to the resulting solution of the 2,4-dichlorobenzylidene-triphenyl phosphorane, after which the whole is boiled under reflux for 5 hours. The tetrahydrofuran is then distilled off, the residue is dissolved in ethylacetate, filtered and the product precipitated from the resulting solution with nitric acid in the same way as in Example 1. Recrystallization from n-butanol give 3 g (72 % of the theoretical) of trans-1-(4-bromophenyl)-2-(2,4-dichlorophenyl)-3-(imidazolyl-1)-propene-1-nitrate melting at 201 C.

Reference： [1]Patent: US4057545,1977,A

28
2,4-dichloro-ω-(1,2,4-triazolyl-1)-acetophenone [ No CAS ]
[ 2492-23-1 ]
trans-1,2-di-(2,4-dichlorophenyl)-3-(1,2,4-triazolyl-1)-propene-1-nitrate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium tert-butylate; nitric acid; In ethanol; benzene;	EXAMPLE 3 5.4 g of 2,4-dichloro-omega-(1,2,4-triazolyl-1)-acetophenone and 14.4 g of <strong>[2492-23-1]2,4-dichlorobenzyltriphenylphosphonium chloride</strong> are suspended in 250 ml of benzene. After the addition of 3.5 g of potassium tert-butylate the mixture is refluxed for 12 hours. The benzene is then distilled off, the residue is dissolved in 100 ml of ethanol, and concentrated nitric acid is added until the solution has an acid reaction. By diluting the solution with water, an oily product is obtained which, after recrystallization from isopropanol, gives 5 g (52% of theory) of trans-1,2-di-(2,4-dichlorophenyl)-3-(1,2,4-triazolyl-1)-propene-1-nitrate having a melting point of 135 to 140 C (compound no. 6 in the table below).

Reference： [1]Patent: US4104399,1978,A

29
[ 104-87-0 ]
[ 2492-23-1 ]
[ 24815-57-4 ]