Alternatived Products of [ 249647-26-5 ]
Product Details of [ 249647-26-5 ]
CAS No. : | 249647-26-5 |
MDL No. : | MFCD09836677 |
Formula : |
C7H6BrIO
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
312.93
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 249647-26-5 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 249647-26-5 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 249647-26-5 ]
- 1
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[ 249647-25-4 ]
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[ 249647-26-5 ]
- 2
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[ 249647-24-3 ]
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[ 249647-26-5 ]
Yield | Reaction Conditions | Operation in experiment |
82% |
|
A solution of <strong>[249647-24-3]methyl 3-bromo-4-iodobenzoate</strong> (4.3 g, 12.6 mmol) in CH2Cl2 was cooled, under N2, to -78 C. DIBAL-H (25.2 mL of a 1M solution in CH2Cl2) was added slowly to the solution, which was stirred at -78 C. for 45 minutes and then allowed to come to room temperature. Next, the reaction mixture was diluted with 1M HCL (40 mL) and stirred for 30 minutes. The reaction was further diluted with water and extracted with CH2Cl2. The organic phase was dried (Na2SO4) and concentrated under vacuum to afford the intermediate (3.2 g, 82%) as a solid. 1HNMR (CDCl3) delta ppm: 7.85 (1H), 7.67 (1H), 7.02 (1H), 4.65 (2H), 1.76 (1H, OH). |
82% |
With diisobutylaluminium hydride; In dichloromethane; at -78℃; for 0.75h;Inert atmosphere; |
A solution of <strong>[249647-24-3]methyl 3-bromo-4-iodobenzoate</strong> (Preparation 23, 4.3 g, 12.6 mmol) in CH2Cl2 was cooled, under N2, to -78 C. DIBAL-H was added slowly to the solution, which was stirred at -78 C. for 45 minutes and then allowed to come to room temperature. Next, the reaction mixture was diluted with 1M HCL (40 mL) and stirred for 30 minutes. The reaction was further diluted with water and extracted with CH2Cl2. The organic phase was dried (Na2SO4) and concentrated under vacuum to afford the intermediate (3.2 g, 82%) as a solid. 1HNMR (CDCl3): 7.85 (1H), 7.67 (1H), 7.02 (1H), 4.65 (2H), 1.76 (1H, OH). |