Home Cart 0 Sign in  
X

[ CAS No. 25016-01-7 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 25016-01-7
Chemical Structure| 25016-01-7
Structure of 25016-01-7 * Storage: {[proInfo.prStorage]}

Quality Control of [ 25016-01-7 ]

Related Doc. of [ 25016-01-7 ]

SDS
Alternatived Products of [ 25016-01-7 ]
Alternatived Products of [ 25016-01-7 ]

Product Details of [ 25016-01-7 ]

CAS No. :25016-01-7 MDL No. :MFCD00003347
Formula : C8H7BrO2 Boiling Point : 289.1°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :215.04 g/mol Pubchem ID :90684
Synonyms :

Safety of [ 25016-01-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 25016-01-7 ]

  • Upstream synthesis route of [ 25016-01-7 ]
  • Downstream synthetic route of [ 25016-01-7 ]

[ 25016-01-7 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 25016-01-7 ]
  • [ 16740-73-1 ]
Reference: [1] Drug Metabolism and Disposition, 2012, vol. 40, # 10, p. 2002 - 2008,7
  • 2
  • [ 25016-01-7 ]
  • [ 35431-26-6 ]
Reference: [1] Journal of the American Chemical Society, 2006, vol. 128, # 33, p. 10694 - 10695
  • 3
  • [ 25016-01-7 ]
  • [ 7062-40-0 ]
Reference: [1] Journal of Medicinal Chemistry, 1995, vol. 38, # 12, p. 2050 - 2060
  • 4
  • [ 25016-01-7 ]
  • [ 80866-82-6 ]
Reference: [1] Patent: JP2005/120047, 2005, A, . Location in patent: Page/Page column 89-90
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 3, p. 528 - 542
[3] Molecules, 2011, vol. 16, # 9, p. 7458 - 7479
[4] Synlett, 2012, vol. 23, # 8, p. 1205 - 1208
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2667 - 2677
[6] Journal fuer Praktische Chemie (Leipzig), 1958, vol. <4> 6, p. 170,172
[7] Journal of Medicinal Chemistry, 1995, vol. 38, # 12, p. 2050 - 2060
[8] Tetrahedron Letters, 2006, vol. 47, # 46, p. 8021 - 8024
  • 5
  • [ 25016-01-7 ]
  • [ 81224-16-0 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1373 - 1377
  • 6
  • [ 25016-01-7 ]
  • [ 144649-99-0 ]
YieldReaction ConditionsOperation in experiment
97% for 15 h; Reflux 5-Bromo-2-methoxybenzaldehyde (20.00 mmol, 4.30 g) was dissolved in formic acid (20 mL) and treated with hydroxylamine hydrochloride (21.00 mmol, 1.45 g) and sodium acetate (26.00 mmol, 2.13 g). The reaction mixture was heated at reflux for 15 hours. The solvent was removed under reduced pressure and the residue was taken up in ethyl acetate (250 mL). The organics were washed with saturated sodium bicarbonate solution (2.x.200 mL) and then dried with MgSO4. The organics were filtered and evaporated under reduced pressure to yield the title compound as a white solid. Yield=4.10 g, 97percent. Analytical LCMS method 2, retention time 6.07 min, M+H=214, 216. 1H NMR: (CDCl3) δ: 7.66-7.61 (m, 2H), 6.87 (d, 1H), 3.92 (s, 3H).
Reference: [1] Science China Chemistry, 2015, vol. 58, # 4, p. 747 - 750
[2] Patent: US2009/247519, 2009, A1, . Location in patent: Page/Page column 143
[3] Patent: US2003/18025, 2003, A1,
[4] Patent: US5633376, 1997, A,
[5] Patent: US5159083, 1992, A,
  • 7
  • [ 25016-01-7 ]
  • [ 679433-91-1 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 4, p. 715 - 734
  • 8
  • [ 25016-01-7 ]
  • [ 166530-78-5 ]
Reference: [1] Synlett, 2016, vol. 27, # 9, p. 1339 - 1343
Historical Records

Related Functional Groups of
[ 25016-01-7 ]

Bromides

Chemical Structure| 43192-33-2

[ 43192-33-2 ]

4-Bromo-2-methoxybenzaldehyde

Similarity: 0.98

Chemical Structure| 138505-25-6

[ 138505-25-6 ]

5-Bromo-2-isopropoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 31558-41-5

[ 31558-41-5 ]

4-Bromo-2,5-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 1354050-38-6

[ 1354050-38-6 ]

4-Bromo-2,6-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 16740-73-1

[ 16740-73-1 ]

1-(5-Bromo-2-methoxyphenyl)ethanone

Similarity: 0.91

Aryls

Chemical Structure| 43192-33-2

[ 43192-33-2 ]

4-Bromo-2-methoxybenzaldehyde

Similarity: 0.98

Chemical Structure| 138505-25-6

[ 138505-25-6 ]

5-Bromo-2-isopropoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 31558-41-5

[ 31558-41-5 ]

4-Bromo-2,5-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 1354050-38-6

[ 1354050-38-6 ]

4-Bromo-2,6-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 16740-73-1

[ 16740-73-1 ]

1-(5-Bromo-2-methoxyphenyl)ethanone

Similarity: 0.91

Ethers

Chemical Structure| 43192-33-2

[ 43192-33-2 ]

4-Bromo-2-methoxybenzaldehyde

Similarity: 0.98

Chemical Structure| 138505-25-6

[ 138505-25-6 ]

5-Bromo-2-isopropoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 31558-41-5

[ 31558-41-5 ]

4-Bromo-2,5-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 1354050-38-6

[ 1354050-38-6 ]

4-Bromo-2,6-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 16740-73-1

[ 16740-73-1 ]

1-(5-Bromo-2-methoxyphenyl)ethanone

Similarity: 0.91

Aldehydes

Chemical Structure| 43192-33-2

[ 43192-33-2 ]

4-Bromo-2-methoxybenzaldehyde

Similarity: 0.98

Chemical Structure| 138505-25-6

[ 138505-25-6 ]

5-Bromo-2-isopropoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 31558-41-5

[ 31558-41-5 ]

4-Bromo-2,5-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 1354050-38-6

[ 1354050-38-6 ]

4-Bromo-2,6-dimethoxybenzaldehyde

Similarity: 0.92

Chemical Structure| 57543-36-9

[ 57543-36-9 ]

5-Bromo-2-hydroxy-4-methoxybenzaldehyde

Similarity: 0.91