Home Cart 0 Sign in  

[ CAS No. 25055-84-9 ]

{[proInfo.proName]} ,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

type HazMat fee
Excepted Quantity Free
Inaccessible (Haz class 6.1), Domestic USD 41.00
Inaccessible (Haz class 6.1), International USD 64.00
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 83.00
Accessible (Haz class 3, 4, 5 or 8), International USD 133.00
Chemical Structure| 25055-84-9
Chemical Structure| 25055-84-9
Structure of 25055-84-9 * Storage: {[proInfo.prStorage]}

Quality Control of [ 25055-84-9 ]

Related Doc. of [ 25055-84-9 ]

SDS
Alternatived Products of [ 25055-84-9 ]
Alternatived Products of [ 25055-84-9 ]

Product Details of [ 25055-84-9 ]

CAS No. :25055-84-9 MDL No. :MFCD25961524
Formula : C11H14N2O3S Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :254.31 g/mol Pubchem ID :14654049
Synonyms :

Safety of [ 25055-84-9 ]

Signal Word:Danger Class:8
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501 UN#:1760
Hazard Statements:H315-H318-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 25055-84-9 ]

  • Downstream synthetic route of [ 25055-84-9 ]

[ 25055-84-9 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 19879-84-6 ]
  • [ 25055-84-9 ]
  • [ 129451-60-1 ]
  • 2
  • 2,3,4,6-tetra-O-acetyl-1-thio-D-galactopyranose [ No CAS ]
  • [ 25055-84-9 ]
  • [ 129451-65-6 ]
  • 3
  • [ 28170-13-0 ]
  • [ 25055-84-9 ]
  • [ 136353-73-6 ]
YieldReaction ConditionsOperation in experiment
With dmap; triethylamine; In dichloromethane; at 0 - 20℃; for 3.0h; General procedure: [0229] Tosylation or brosylation of alcohols: To a solution of alcohol (1 equiv.), Et3N (1.5-2.0 equiv.), and N, N-dimethylamino-pyridine (DMAP, 0.5-1 equiv.) in CH2C12 was slowly added a solution of p- toluenesulfonic chloride (TsCl) or 4-bromobehzene-l-sulfonyl chloride (BsCl) (1.1-1.3 equiv.) in CH2CI2 at 0 C. The reaction mixture was stirred at 0 C for 1 h, and then warmed to room temperature for another 3 h. After diluted with water, the reaction mixture was extracted with more CH2Cl2. The organic layer was combined, dried (Na2S04), filtered, and concentrated to yield the crude product, which was then purified by column chromatography [0252] 2-Pentyl tosylate (3h). This compound was synthesized as a colorless oil from 2- pentanol (122.0 mg, 1.384 mmol), TsCl (316.6 mg, 1.66 mmol), Et3N (280.3 mg, 2.77 mmol), and DMAP (169.0 mg, 1.384 mmol) in 92% yield by following general procedure 1.1 : 1H NMR (400 MHz, CDC13; 5H) 7.75 (d, J= 8.3 Hz, 2H), 7.30 (d,J= 8.3 Hz, 2H), 4.63 - 4.51 (m, 1H), 2.40 (s, 3H), 1.56 (dddd, J= 14.0, 10.0, 7.2, 5.4 Hz, 1H), 1.49 - 1.35 (m, 1H), 1.35 - 1.04 (m, 5H), 0.77 (t, J= 1A Hz, 3H); 13C NMR (100 MHz, CDC13, 8C) 144.57, 134.63, 129.84, 127.78, 80.55, 38.70, 21.73, 20.90, 18.28, 13.74. ESI-MS: 243.1 (M+H+), 265.1 (M+Na+).
  • 5
  • [ 402820-38-6 ]
  • [ 25055-84-9 ]
  • 3-(3-hydroxy-3-phenylpropyl)-4-(4-methoxyphenyl)-1-(4-[2-(3-methyl-3H-diazirin-3-yl)-ethylamino]methyl}phenyl)-azetidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
In N-methyl-acetamide; methanol; dichloromethane; water; toluene; 3-(3-Hydroxy-3-phenylpropyl)-4-(4-methoxyphenyl)-1-(4-[2-(3-methyl-3H-diazirin-3-yl)ethylamino]methyl}phenyl)azetidin-2-one 100 mg of 1-(4-aminomethylphenyl)-3-(3-hydroxy-3-phenylpropyl)-4-(4-methoxy-phenyl)azetidin -2-one are dissolved in 5 ml of dimethylformamide and stirred with 2-(3-methyl-3H-diazirin-3-yl)ethyl toluene-4-sulfonate under subdued light at 60-70 C. for 6 h. Water is added and, after extraction with ethyl acetate, the solvent is removed in vacuo. Then dry toluene is added and the mixture is concentrated in vacuo twice. The crude product is purified on silica gel using dichloromethane/methanol =20:1 as mobile phase. MS (ESI): 499 (M+H+) [C30H34N4O3 M=498].
  • 6
  • [ 773837-37-9 ]
  • [ 25055-84-9 ]
  • [ 1255731-57-7 ]
  • 7
  • [ 98-59-9 ]
  • [ 25055-82-7 ]
  • [ 25055-84-9 ]
YieldReaction ConditionsOperation in experiment
428 mg With pyridine; at 0 - 4℃; for 24h;Inert atmosphere; 4-hydroxy-2-butanone (20, 1.00 g, 11.35 mmol) was pipetted into a dry flask and cooled to 0C under nitrogen atmosphere. 7N methanolic ammonia (11.2 mL, 79 mmol) was added via syringe, and the solution was allowed to stir at 0C for 3 hours. A solution of hydroxylamine-O-sulfonic acid (1.476 g, 13.05 mmol) in methanol (9.7 mL) was added dropwise, then was allowed to stir for an additional 16 hours while slowly warming to room temperature. The reaction was filtered through a sintered glass funnel, then transferred to a reaction vessel and re-cooled to 0C. Triethylamine (1.58 mL,11.35 mmol) was added, then molecular iodine (2.88 g, 11.35 mmol) was added slowly in 10 equal portions until the purple/brown color of iodine persisted in the reaction vessel. The solvent was removed under reduced pressure, and purification of the crude isolate via Kugelrohr distillation (60C, 1-3 torr) delivered the 2,2-diazirinyl intermediate as a clear oil (304 mg, 27% yield). A portion of this intermediate (300 mg, 3.00 mmol) was dissolved in dry pyridine (6 mL) and cooled to 0C in an ice bath. To this solution was added p-toluenesulfonyl chloride (628 mg, 3.30 mmol). The reaction mixture was allowed to stir for 24 hours at 0-4C, then was poured into a mixture of 37%w/v HCl (15 mL) and ice (80 mL). The resulting suspension was extracted 3x with ether, then the pooled organic layers were washed with 1N HCl solution, 1N NaOH solution, water, and brine. The organic extract was dried over MgSO4, vacuum filtered, and concentrated to a clear oil (428 mg, 15% yield over 3 steps) used without further purification. TLC Rf (2:1 hex:EtOAc) = 0.6. 1HNMR (500 MHz, CDCl3) delta 7.82 (d, J = 7.9 Hz, 2H), 7.37 (d, J= 7.9 Hz, 2H), 3.96 (t, J = 6.4 Hz, 2H), 2.46 (s, 3H), 1.68 (t, J= 6.4 Hz, 2H), 1.01 (s, 2H).
  • 8
  • [ 889108-22-9 ]
  • [ 25055-84-9 ]
  • [ 1339804-10-2 ]
  • 9
  • [ 1579956-90-3 ]
  • [ 25055-84-9 ]
  • [ 1579957-03-1 ]
YieldReaction ConditionsOperation in experiment
45% With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 50℃; for 16.0h; Thiourea 17 (100 mg, 0.318 mmol) was dissolved in dry DMF (1.9 mL) and heated to 50C. Sodium bicarbonate (53 mg, 0.636 mmol) was added, followed by alkylating agent 21 (121mg, 0.477 mmol). Reaction was allowed to stir for 16h at 50C. Reaction mixturewas diluted with sat. aq. NH4Cl, causing a white precipitate to form. The suspension was extracted with EtOAc 3x, then the organic layer was washed 2x with water and 1x with brine. The organic extract was dried over MgSO4, vacuum filtered, and concentrated, leaving an impurewhite solid. Trituration with diethyl ether furnished the desired product as 57mg of a white solid (45% yield). 1H NMR (400 MHz, DMSO-d6)δ 9.93 (s, 1H), 7.85 (d, J = 8.5 Hz, 1H), 6.72 (dd, J = 8.5, 2.4Hz, 1H), 6.64 (d, J = 2.4 Hz, 1H), 5.86 (ddt, J = 16.6, 10.4, 5.1Hz, 1H), 5.21 (d, J = 10.4 Hz, 1H), 5.11 (d, J = 16.6 Hz, 2H),4.57 (d, J = 5.1 Hz, 2H), 3.21 (t, J = 7.6 Hz, 2H), 2.67 (s, 2H),1.80 (t, J = 7.6 Hz, 2H), 1.26 (s, 6H), 1.09 (s, 3H).
  • 10
  • [ 1579956-91-4 ]
  • [ 25055-84-9 ]
  • [ 1579956-92-5 ]
YieldReaction ConditionsOperation in experiment
16% With caesium carbonate; In N,N-dimethyl-formamide; at 70℃; for 1.0h; Phenolintermediate 18a (30 mg, 0.085mmol), alkylating agent 21 (16 mg,0.063 mmol), and cesium carbonate (37 mg, 0.113 mmol) were combined in dry DMF(0.3 mL). The reaction was capped andheated to 70C for 1 hour. The reaction mixture was diluted with water, and extracted 2x with diethyl ether. The organic layer was then washed with water and brine, dried over MgSO4, vacuum filtered, and concentrated. The resulting residue was purified via flash chromatography (0-10% EtOAc:hex) to furnish the product as a white solid (4 mg,16% yield). 1H NMR (400 MHz, CDCl3) δ 8.08 (d, J =8.6 Hz, 1H), 6.83 (dd, J = 8.6, 2.4 Hz, 1H), 6.75 - 6.64 (m, 2H), 5.92(ddt, J = 15.9, 10.7, 5.5 Hz, 1H), 5.37 - 5.22 (m, 2H), 5.16 (d, J= 6.5 Hz, 2H), 4.65 (d, J = 5.5 Hz, 2H), 3.93 (t, J = 6.3 Hz,2H), 2.74 (s, 2H), 1.84 (t, J = 6.3 Hz, 2H), 1.37 (s, 6H), 1.14 (s, 3H).ESI+MS m/z = 435.2 (M + H+),457.2 (M + Na+).
  • 11
  • [ 1579957-02-0 ]
  • [ 25055-84-9 ]
  • [ 1579957-04-2 ]
YieldReaction ConditionsOperation in experiment
64% With caesium carbonate; In N,N-dimethyl-formamide; at 75℃; for 4.0h; Phenolintermediate 18a (30 mg, 0.085mmol), alkylating agent 21 (16 mg,0.063 mmol), and cesium carbonate (37 mg, 0.113 mmol) were combined in dry DMF(0.3 mL). The reaction was capped andheated to 70C for 1 hour. The reaction mixture was diluted with water, and extracted 2x with diethyl ether. The organic layer was then washed with water and brine, dried over MgSO4, vacuum filtered, and concentrated. The resulting residue was purified via flash chromatography (0-10% EtOAc:hex) to furnish the product as a white solid (4 mg,16% yield). 1H NMR (400 MHz, CDCl3) δ 8.08 (d, J =8.6 Hz, 1H), 6.83 (dd, J = 8.6, 2.4 Hz, 1H), 6.75 - 6.64 (m, 2H), 5.92(ddt, J = 15.9, 10.7, 5.5 Hz, 1H), 5.37 - 5.22 (m, 2H), 5.16 (d, J= 6.5 Hz, 2H), 4.65 (d, J = 5.5 Hz, 2H), 3.93 (t, J = 6.3 Hz,2H), 2.74 (s, 2H), 1.84 (t, J = 6.3 Hz, 2H), 1.37 (s, 6H), 1.14 (s, 3H).ESI+MS m/z = 435.2 (M + H+),457.2 (M + Na+).
  • 12
  • [ 623-05-2 ]
  • [ 25055-84-9 ]
  • [ 1620483-11-5 ]
  • 13
  • [ 908072-33-3 ]
  • [ 25055-84-9 ]
  • [ 1620483-24-0 ]
  • 15
  • [ 540-38-5 ]
  • [ 25055-84-9 ]
  • C10H11IN2O [ No CAS ]
Historical Records