* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With C33H40ClN3O2Pd; potassium <i>tert</i>-butylate In toluene at 130℃; for 24 h; Inert atmosphere; Schlenk technique; Sealed tube
General procedure: Under a N2 atmosphere, KOtBu (102.1 mg, 1.3 equiv) and a so-lution of complex 3a (10e50 mL, 0.01e0.05 molpercent, prepared from4.6 mg of complex 3a in 1.0 mL dichloromethane) were added into aSchlenk reaction tube. The tube was sealed and the solvent wasremoved under reduced pressure. Then toluene (0.5 mL), amines(0.84 mmol) and aryl chlorides (0.70 mmol) were successivelyadded. The mixture was stirred vigorously at the specied tem-perature for 3e24 h. Then the solvent was removed under reducedpressure and the residue was puried by ash column chroma-tography (SiO2) to give the corresponding products.
Reference：
[1] Advanced Synthesis and Catalysis, 2008, vol. 350, # 5, p. 652 - 656
[2] Tetrahedron, 2017, vol. 73, # 52, p. 7308 - 7314
2
[ 62-53-3 ]
[ 25078-04-0 ]
Yield
Reaction Conditions
Operation in experiment
95%
With cyclopentadienyl[(1,2,3-n)-1-phenyl-2-propenyl]palladium(II); potassium carbonate; [5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl]diphenylphosphane In 1,4-dioxane at 80℃; for 18 h; Inert atmosphere
General procedure: I n this Example, an aryl fluorosulfonate is reacted with aniline as shown in Equation 7: Equation 7 [0051] The present Example is performed in a nitrogen- filled glovebox. To each of 12 30 mL vials are added one of the aryl fluorosulfonates selected from Table 1 where R in Equation 7 represents one or more groups joined to the aryl ring as shown (2.50 mmol), Xantphos (0.017 g; 0.03 mmol); potassium carbonate (0.691 g; 5.00 mmol), and 1,4-dioxane (5 mL). To each stirring mixture is added aniline (274 uL) and CpPd (cinnamyl) (0.007 g in 100 uL 1,4-dioxane). Each reaction mixture is heated at 80 °C for 12 to 24 hours. The reaction mixture is cooled to room temperature and adsorbed onto silica gel. The product is purified by flash chromatography (ISCO, manufactured by Teledyne) and the volatiles are removed by vacuum to reveal the desired product having yields recorded in Table 1.
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper; acetic acid In acetonitrile
General procedure: An Omnifit glass column (6.6×150mm) was filled with copper powder (5.5cm height) and connected to a 10mL stainless steel reactor coil and both were heated to 100°C using a Vapourtec R4 reactor module. Using a Vapourtec R2C+ flow chemistry system, a 2mL solution containing arylboronic acid (0.8mmol) and amine (2.4mmol) in acetonitrile was placed in 2mL sample loop A and 2mL solution containing TEMPO (1.2mmol) and acetic acid (1.6mmol) in acetonitrile was placed in 2mL sample loop B. The reactants were progressed through the copper column and SS coil reactor (0.30mL/min), with each sample loop/pump set at 0.15mL/min, and a 250psi back-pressure regulator and collected in a 100mL RB flask. The solvent removed and product purified with a Teledyne Combiflash Rf and silica gel column chromatography in ethyl acetate:hexane (typically 1:19) to yield an isolated product.
Reference：
[1] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 16, p. 2695 - 2701
8
[ 108-38-3 ]
[ 622-37-7 ]
[ 25078-04-0 ]
Reference：
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 2615 - 2620
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2725 - 2732
[3] Chemische Berichte, 1949, vol. 82, p. 260,262
9
[ 303051-44-7 ]
[ 25078-04-0 ]
Reference：
[1] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 16, p. 2695 - 2701
[2] Chemische Berichte, 1907, vol. 40, p. 4543
10
[ 1122-42-5 ]
[ 25078-04-0 ]
Reference：
[1] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 16, p. 2695 - 2701
11
[ 103-84-4 ]
[ 25078-04-0 ]
Reference：
[1] Journal of the Chemical Society, Perkin Transactions 1, 2000, # 16, p. 2695 - 2701
With potassium carbonate In sulfolane at 220 - 225℃; for 6h;
2
(Synthesis of p-Terphenyl Compound Mixture Composed of Compounds No. 1, No. 17, and No.4) The following ingredients were mixed together: 16.86 g (92 mmol) of 4-methyldiphenylamine, 4.53 g (23 mmol) of 2,4-dimethyldiphenylamine, 24.1 g (50 mmol) of 4,4'-diiodo-p-terphenyl, 17.25 g (125 mmol) of anhydrous potassium carbonate, 0.32 g (5 mmol) of a copper powder, 0.52 g (5 mmol) of sodium hydrogen sulfite, and 10 mL of sulfolane. The resultant mixture was heated to 220-225°C and stirred for 6 hours while introducing nitrogen gas. After completion of the reaction, a reaction product was extracted with 90 mL of xylene and 150 mL of toluene, and the insoluble matter was removed by filtration. Thereafter, the filtrate was concentrated to dryness. The solid matter obtained was purified by column chromatography (support: silica gel, eluent: toluene:hexane=1:4). Thus, a p-terphenyl compound mixture composed of 4,4'-bis(4-methyldiphenylamino)-p-terphenyl (Compound No. 1), 4-(4-methyldiphenylamino)-4'-(2,4-dimethyldiphenylamino)-p-terphenyl (Compound No. 17), and 4,4'-bis(2,4-dimethyldiphenylamino)-p-terphenyl (Compound No. 4) in a ratio of Compound No. 1/Compound No. 17/Compound No. 4 = 69.0/27.2/2.9 (peak area ratio in high-performance liquid chromatography) was obtained in an amount of 26.65 g (yield: 89.1%, melting point: 174.1-177.0°C).
With sodium t-butanolate In toluene at 20 - 130℃; Inert atmosphere;
4
3g (30 mmol) of sodium tert-butoxide, 217 mg (0.5 mmol) of IPr-HCl (compound No. 1), 45 mg (0.2 mmol) of palladium(II) acetate, 3.94 g (20 mmol) of 2,4-dimethyldiphenylamine, 3.2 g (10 mmol) of 4,4'-dibromobiphenyl and 30 ml of toluene were put into a 50-ml three-neck flask equipped with a stirrer, a condenser tube, a thermometer and a gas-introducing duct, in an argon current at room temperature, and reacted under reflux in an oil bath controlled at a temperature of 130°C for 8 hours. The reaction liquid was cooled to room temperature, then left overnight at room temperature, and 200 ml of methylene chloride was added thereto. The insoluble matter was removed by filtration, and the filtrate was washed twice with 50 ml of water. This was dewatered and dried with 30 g of anhydrous sodium sulfate, and the solvent was evaporated away to give a residue. The residue was purified through column chromatography (carrier, Fuji Silicia's NH silica gel 300 g; eluent, cyclohexane/tetrahydrofuran) to give 4.95 g of N,N'-bis(2',4'-dimethylphenyl)-N,N'-diphenylbenzidine (yield 91%).
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