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Chemical Structure| 25095-94-7

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Product Details of [ 25095-94-7 ]

CAS No. :25095-94-7
Formula : C14H8O3S
M.W : 256.28
SMILES Code : O=C(C1=CC(C2=O)=C(SC3=C2C=CC=C3)C=C1)O
MDL No. :MFCD03840789
InChI Key :PPFNJKRRFYQNLD-UHFFFAOYSA-N
Pubchem ID :429296

Safety of [ 25095-94-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 25095-94-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25095-94-7 ]

[ 25095-94-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 25095-94-7 ]
  • [ 119692-59-0 ]
  • [ 1214748-79-4 ]
YieldReaction ConditionsOperation in experiment
With 2,6-di-tert-butyl-4-methyl-phenol; tetrabutylammomium bromide; In ISOPROPYLAMIDE; acetonitrile; for 24.0h;Reflux; Synthesis of TX-2; [0142] Synthesis of 9-oxo-9H-thioxanthene-2-carboxylic acid-3-(4-acryloyloxy- butoxy)2-hydroxy-propyl ester:A reaction mixture containing 9-oxo-9H-thioxanthene-2-carboxylic acid(2.0 g, 7.8 mmol), acetonitrile (30 mL), dimethylacetamide (20 mL), tetrabutylammonium bromide (0.3 g, 0.78 mmol)and 2,6-di-tert-butyl-4- methylphenol (0.02 g, 0.0634 mmol) was heated to reflux.At this temperature 4-hydroxybutylacrylate glycidylether (1.3 g, 6.34 mmol) was added and the mixture was allowed to stir at reflux temperature for 24 hours.The mixture was cooled to room temperature and filtered to remove the residual, undissolved 9-oxo-9H-thioxanthene-2-carboxylic acid. The filtrate was evaporated under reduced pressure.The residual oil was dissolved in methyl-tert-butylether (100 mL) and extracted with a mixture of an aqueous solution of sodium hydroxide (1 N) and distilled water (1/4).The organic layer was separated, dried on MgSO^ filtered and evaporated to provide 2.5 g of a brown oil.
With 2,6-di-tert-butyl-4-methyl-phenol;tetrabutylammomium bromide; In N,N-dimethyl acetamide; acetonitrile; for 24.0h;Reflux; A reaction mixture containing 9-oxo-9H-thioxanthene-2-carboxylic acid (2.0 g, 7.8 mmol), acetonitrile (30 mL), dimethylacetamide (20 mL), tetrabutylammonium bromide (0.3 g, 0.78 mmol) and 2,6-di-tert-butyl-4-methylphenol (0.02 g, 0.0634 mmol) was heated to reflux. At this temperature 4-hydroxybutylacrylate glycidylether (1.3 g, 6.34 mmol) was added and the mixture was allowed to stir at reflux temperature for 24 hours. The mixture was cooled to room temperature and filtered to remove the residual, undissolved 9-oxo-9H-thioxanthene-2-carboxylic acid. The filtrate was evaporated under reduced pressure. The residual oil was dissolved in methyl-tert-butylether (100 mL) and extracted with a mixture of an aqueous solution of sodium hydroxide (1 N) and distilled water (1/4). The organic layer was separated, dried on MgSO4, filtered and evaporated to provide 2.5 g of a brown oil.
2.5 g With 2,6-di-tert-butyl-4-methyl-phenol; tetrabutylammomium bromide; In N,N-dimethyl acetamide; acetonitrile; for 24.0h;Reflux; Synthesis of 9-oxo-9H-thioxanthene-2-carboxylic acid-3-(4-acryloyloxy-butoxy)-2-hydroxy-propyl ester A reaction mixture containing 9-oxo-9H-thioxanthene-2-carboxylic acid (2.0 g, 7.8 mmol), acetonitrile (30 mL), dimethylacetamide (20 mL), tetrabutylammonium bromide (0.3 g, 0.78 mmol) and 2,6-di-tert-butyl-4-methylphenol (0.02 g, 0.0634 mmol) was heated to reflux. At this temperature 4-hydroxybutylacrylate glycidylether (1.3 g, 6.34 mmol) was added and the mixture was allowed to stir at reflux temperature for 24 hours. The mixture was cooled to room temperature and filtered to remove the residual, undissolved 9-oxo-9H-thioxanthene-2-carboxylic acid. The filtrate was evaporated under reduced pressure. The residual oil was dissolved in methyl-tert-butylether (100 mL) and extracted with a mixture of an aqueous solution of sodium hydroxide (1N) and distilled water (1/4). The organic layer was separated, dried on MgSO4, filtered and evaporated to provide 2.5 g of a brown oil.
  • 2
  • [ 25095-94-7 ]
  • [ 128-37-0 ]
  • [ 119692-59-0 ]
  • [ 1214748-79-4 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; tetrabutylammomium bromide; In tert-butyl methyl ether; ISOPROPYLAMIDE; water; acetonitrile; Synthesis of Comparative Initiator CTX-2 Synthesis of 9-oxo-9H-thioxanthene-2-carboxylic acid-3-(4-acryloyloxy-butoxy)-2-hydroxy-propyl ester: A reaction mixture containing 9-oxo-9H-thioxanthene-2-carboxylic acid (2.0 g, 7.8 mmol), acetonitrile (30 mL), dimethylacetamide (20 mL), tetrabutylammonium bromide (0.3 g, 0.78 mmol) and 2,6-di-tert-butyl-4-methylphenol (0.02 g, 0.0634 mmol) was heated to reflux. At this temperature 4-hydroxybutylacrylate glycidylether (1.3 g, 6.34 mmol) was added and the mixture was allowed to stir at reflux temperature for 24 hours. The mixture was cooled to room temperature and filtered to remove the residual, undissolved 9-oxo-9H-thioxanthene-2-carboxylic acid. The filtrate was evaporated under reduced pressure. The residual oil was dissolved in methyl-tert-butylether (100 mL) and extracted with a mixture of an aqueous solution of sodium hydroxide (1N) and distilled water (1/4). The organic layer was separated, dried on MgSO4, filtered and evaporated to provide 2.5 g of a brown oil.
 

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