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Chemical Structure| 251366-53-7 Chemical Structure| 251366-53-7

Structure of 251366-53-7

Chemical Structure| 251366-53-7

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Product Details of [ 251366-53-7 ]

CAS No. :251366-53-7
Formula : C9H9BrO3
M.W : 245.07
SMILES Code : O=C(C(C1C(OC)=CC=CC=1)Br)O
MDL No. :MFCD32174106

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Application In Synthesis of [ 251366-53-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 251366-53-7 ]

[ 251366-53-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 251366-53-7 ]
  • [ 1147557-97-8 ]
  • 2-[(6-t-butoxycarbonyl-6-azaspiro[3.3]heptane-2-yl)oxy]-2-(2-methoxyphenyl)acetic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
90.9% t-Butyl 2-hydroxy-6-azaspiro[3.3]heptane-6-carboxylate (1.80 g, 8.44 mmol) wasdissolved in tetrahydrofuran ( 40 mL ). The mixture was cooled to 0 °C under N2, and sodiumhydride (1.01 g, 25.3 mmol, 60percent) was added. The mixture was stirred for 10 min and furtherstirred at rt for 30 min, and then 2-bromo-2-(2-methoxyphenyl)acetic acid (1.86 g, 7.59 mmol)was added. The resulting mixture was stirred at rt for 18 hours. The mixture was cooled to 0 °C,and quenched with saturated aqueous ammonium chloride (0.5 mL). The mixture was stirred for30 min, water (10 mL) and ethyl acetate (20 mL) were added, and the mixture was stirred for 10min. After the mixture was partitioned, the water phase was adjusted to pH about 3 with dilutehydrochloric acid (1 N) and extracted with ethyl acetate (20 mL x 2). The combined organicphases were washed with saturated aqueous NaCl and dried over anhydrous sodium sulfate, andfiltered. The filtrate was concentrated in vacuo to get the title compound as a red oil (2.9 g,90.9percent).MS (ESI, pos. ion) m/z:400.1[M+Nat
 

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