Home Cart Sign in  
Chemical Structure| 252662-37-6 Chemical Structure| 252662-37-6

Structure of 252662-37-6

Chemical Structure| 252662-37-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 252662-37-6 ]

CAS No. :252662-37-6
Formula : C6H6N2O2S
M.W : 170.19
SMILES Code : CC(NC1=NC=C(C=O)S1)=O
MDL No. :MFCD09909306

Safety of [ 252662-37-6 ]

Application In Synthesis of [ 252662-37-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 252662-37-6 ]

[ 252662-37-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1003-61-8 ]
  • [ 108-24-7 ]
  • [ 252662-37-6 ]
  • 2
  • [ 1003-61-8 ]
  • [ 252662-37-6 ]
YieldReaction ConditionsOperation in experiment
With acetic anhydride; In toluene; B. Preparation of 2-acetamido-thiazol-5-ylcarboxaldehyde To a suspension of 2-amino-thiazol-5-ylcarboxaldehyde (5.0 g, 39 mmol) in toluene (500 mL) was added acetic anhydride (11.0 mL, 117 mmol). The mixture was heated to 110 C. for 5 hours. Upon cooling to room temperature, a solid precipitated out of the solution. The reaction mixture was concentrated under vacuum to give 2-acetamido-thiazol-5-ylcarboxaldehyde as a light brown colored solid (6.5 g, 98%, C6H6N2O2S, MS m/e 171 (M+H)+).
  • 3
  • [ 1003-61-8 ]
  • [ 75-36-5 ]
  • [ 252662-37-6 ]
YieldReaction ConditionsOperation in experiment
65% With diisopropylamine; In dichloromethane; at 0 - 20℃; for 17h; Acetyl choride (6 mL, 84.38 mmol) was added to a solution of 2-amino-5- formylthiazole (10 g, 78 mmol) and diisopropylamine (45 mL, 261.1 mmol) in DCM (100 mL) at 0 C. The resulting mixture was allowed to warm to rt and further stirred atrt for 17 h. NH4C1 (aq. sat. soltn.) was added and the mixture was extracted with EtOAc. The organic layer was separated, dried over MgSO4, filtered and concentrated in vacuo. The residue thus obtained was purified by flash column chromatography (silica; dry load, EtOAc in DCM 0/100 to 50/50) and the desired fractions were concentrated in vacuo to yield intermediate 12 as yellow solid (8.6 g, 65% yield).
65% With diisopropylamine; In dichloromethane; at 0 - 20℃; for 17h; Acetyl choride (6 mL, 84.38 mmol) was added to a solution of 2-amino-5- formylthiazole (10 g, 78 mmol) and diisopropylamine (45 mL, 261.1 mmol) in DCM (100 mL) at 0 C. The resulting mixture was allowed to warm to rt and further stirred at rt for 17 h. NH4C1 (aq. sat. soltn.) was added and the mixture was extracted with EtOAc. The organic layer was separated, dried over MgS04, filtered and concentrated in vacuo. The residue thus obtained was purified by flash column chromatography (silica; dry load, EtOAc in DCM 0/100 to 50/50) and the desired fractions were concentrated in vacuo to yield intermediate 40 as yellow solid (8.6 g, 65% yield).
65% With diisopropylamine; In dichloromethane; at 0 - 20℃; for 17h; Acetyl chloride (6 mL, 84.38 mmol) was added to a solution of 2-amino-5- formylthiazole (10 g, 78 mmol) and diisopropylamine (45 mL, 261.1 mmol) in DCM (100 mL) at 0 C. The resulting mixture was allowed to warm to rt and further stirred at rt for 17 h. NH4C1 (aq. sat. soltn.) was added and the mixture was extracted with EtOAc. The organic layer was separated, dried over MgS04, filtered and concentrated in vacuo. The residue thus obtained was purified by flash column chromatography (silica; dry load, EtOAc in DCM 0/100 to 50/50) and the desired fractions were concentrated in vacuo to yield Intermediate 1 as yellow solid (8.6 g, 65% yield).
65% With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20℃; for 17h; Acetyl choride (6 mL, 84.38 mmol) was added to a solution of 2-amino-5- formylthiazole (10 g, 78 mmol) and diisopropylamine (45 mL, 261.1 mmol) in DCM (100 mL) at 0 C. The resulting mixture was allowed to warm to rt and further stirred at rt for 17 h. NH4C1 (aq. sat. soltn.) was added and the mixture was extracted with EtOAc. The organic layer was separated, dried over MgS04, filtered and concentrated in vacuo. The residue thus obtained was purified by flash column chromatography (silica; dry load, EtOAc in DCM 0/100 to 50/50) and the desired fractions were concentrated in vacuo to yield intermediate 38 as yellow solid (8.6 g, 65 % yield).
With pyridine; In tetrahydrofuran; at 20℃; Compounds 88, 89, 90, 91, 93, 94, 95, 96, 97, 98, 106 and 107 were synthesized by using the materials that have a substituent corresponding to these compounds, according to the following production scheme.
With pyridine; at 0 - 20℃; for 12h; To a stirred solution of 2-formyl-5-amino thiazole (1 eq.) in dry pyridine at 0C was added CH3COCI (1 .2 eq.) dropwise for 10 min. After the addition, the reaction was allowed to stir at RT for 12h. After completion of the reaction, the reaction mixture was evaporated under reduced pressure and H20 was added to get a precipitate which was filtered and air dried to afford the product.

 

Historical Records

Technical Information

Categories