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CAS No. : | 2538-61-6 | MDL No. : | MFCD01861265 |
Formula : | C8H13ClN2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GQKQMDUOOZVZFD-UHFFFAOYSA-N |
M.W : | 172.66 | Pubchem ID : | 12405010 |
Synonyms : |
|
Num. heavy atoms : | 11 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.25 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 49.43 |
TPSA : | 38.05 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.44 cm/s |
Log Po/w (iLOGP) : | 0.0 |
Log Po/w (XLOGP3) : | 2.69 |
Log Po/w (WLOGP) : | -1.49 |
Log Po/w (MLOGP) : | 2.34 |
Log Po/w (SILICOS-IT) : | 1.25 |
Consensus Log Po/w : | 0.96 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -2.94 |
Solubility : | 0.197 mg/ml ; 0.00114 mol/l |
Class : | Soluble |
Log S (Ali) : | -3.14 |
Solubility : | 0.125 mg/ml ; 0.000722 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -2.83 |
Solubility : | 0.254 mg/ml ; 0.00147 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.15 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With hydrogenchloride; tin(ll) chloride In water at 0 - 20℃; for 6.41667 h; | To a cold (0° C.) solution of 2,6-dimethylaniline (5.0 g, 41.3 mmol) in 50percent aqueous HCl (45 mL), was added slowly under stirring a cold (0° C.) solution of NaNO2 (2.85 g, 41.3 mmol) in water (22.5 mL). The temperature was closely monitored during the addition and was not allowed to exceed 5° C. Upon completion of the addition, the bright orange solution containing the diazonium salt intermediate was stirred at the same temperature for 20 min. A mixture of SnCl2 (11.0 g, 57.8 mmol) in conc HCl (30 mL) was added to the reaction mixture at 0° C. over a period of 5 min. The reaction mixture was then warmed to rt and stirred for 6 h. The precipitate was collected by filtration and washed with a small volume of cold water. Drying in vacuo afforded the title compound as a white amorphous solid (7.00 g, 98percent). The product was used in the next step without further purification. ES-MS m/z 137.0 (MH+); HPLC RT (min) 1.09. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | Stage #1: With hydrogenchloride; sodium nitrite In water at -4 - 0℃; for 0.5 h; Stage #2: With hydrogenchloride; tin(II) chloride hydrate In water at 20℃; Stage #3: With sodium hydroxide In water at 15℃; |
To a mixture of concentrated HCl (50 mL) and water (40 mL) was added 2,6-dimethylaniline (24.2 g, 0.2 mol) under vigorous stirring. The resulting mixture was cooled to −4 °C, and a solution of NaNO2 (15.2 g, 0.22 mol) in water (30 mL) was added dropwise to maintain temperature below 0 °C. After addition of the sodium nitrite solution, the reaction mixture was stirred for 30 min. A solution of stannous dichloride hydrate (112.8 g, 0.5 mol) in 160 mL of 6 mol/L hydrochloric acid was added over a period of 1.5 h, during which the temperature of the reaction mixture was maintained below 5 °C. The yellowish slurry was allowed to stand overnight at room temperature and stirring was continued for another 22 h. And then the mixture was cooled by ice-water for 1 h. The pale yellow tin complex salt was collected by filtration, dried on the funnel and washed with brine (50 mL), and ether (2×50 mL). The dry complex salt was stirred in water (100 mL), and slurry was stirred vigorously while it was treated with 10 mol/L NaOH (100 mL). The temperature of the mixture was maintained below 15 °C. The crude hydrazine was extracted from the mixture with ether (2×200 mL), and the etheral solution was washed with water (200 mL) and dried over Na2SO4. The dried etheral solution was diluted with ether to 500 mL. The diluted solution was treated with 4.8 mol/L HCl in 1,4-dioxane (50 mL) until precipitation of the hydrazine hydrochloride was complete. The filtered hydrochloride was washed with ether (50 mL), dried over Na2SO4, and recrystallized from ethanol to afford 2,6-dimethylphenylhydrazine hydrochloride salt as colorless crystals 21.9 g in 63percent yield. 4.2.1. 2,6-Dimethylphenylhydrazine hydrochloride salt. Colorless crystals, mp 210–212 °C dec (Lit.15 211 °C dec), 1H NMR (300 MHz, DMSO-d6) δ: 2.39 (s, 6H), 6.71 (br s, 1H), 7.08 (s, 3H), 9.82 (s, 3H). 13C NMR (50 MHz, DMSO-d6) δ: 140.6, 134.9, 128.6, 126.9, 18.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With hydrogenchloride; tin(ll) chloride; In water; at 0 - 20℃; for 6.41667h; | To a cold (0 C.) solution of 2,6-dimethylaniline (5.0 g, 41.3 mmol) in 50% aqueous HCl (45 mL), was added slowly under stirring a cold (0 C.) solution of NaNO2 (2.85 g, 41.3 mmol) in water (22.5 mL). The temperature was closely monitored during the addition and was not allowed to exceed 5 C. Upon completion of the addition, the bright orange solution containing the diazonium salt intermediate was stirred at the same temperature for 20 min. A mixture of SnCl2 (11.0 g, 57.8 mmol) in conc HCl (30 mL) was added to the reaction mixture at 0 C. over a period of 5 min. The reaction mixture was then warmed to rt and stirred for 6 h. The precipitate was collected by filtration and washed with a small volume of cold water. Drying in vacuo afforded the title compound as a white amorphous solid (7.00 g, 98%). The product was used in the next step without further purification. ES-MS m/z 137.0 (MH+); HPLC RT (min) 1.09. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; water; | EXAMPLE 2b: 2-Chloroethyl 2-(2,6-dimethylphenyl)-hydrazinecarboxylate A mixture of 17.7 g (0.1 mol) <strong>[2538-61-6]2,6-dimethylphenylhydrazine hydrochloride</strong>, 21.2 g (0.2 mol) sodium carbonate in 50 ml water and 50 ml xylene are stirred for 30 minutes at room temperature, then cooled to 5. 14.3 g (0.1 mol) chloroformic acid 2-chloroethylester is then added over a period of 1 hour, the temperature being maintained at 5. The mixture is stirred at 5 for another hour, at the end of which 100 ml water are added, the precipitate thus formed filtered off, washed with water and dried. Further work-up as in Example 1b. In analogous manner to that described in the preceding Examples 1 and 2 the following compounds of formula I are produced | |
With sodium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; water; | Example 2b 2-Chloroethyl 2-(2,6-dimethylphenyl)-hydrazinecarboxylate A mixture of 17.7 g (0.1 mol) <strong>[2538-61-6]2,6-dimethylphenylhydrazine hydrochloride</strong>, 21.2 g (0.2 mol) sodium carbonate in 50 ml water and 50 ml xylene are stirred for 30 minutes at room temperature, then cooled to 5. 14.3 g (0.1 mol) chloroformic acid 2-chloroethylester is then added over a period of 1 hour, the temperature being maintained at 5. The mixture is stirred at 5 for another hour, at the end of which 100 ml water are added, the precipitate thus formed filtered off, washed with water and dried. Further work-up as in Example 1b. In analogous manner to that described in the preceding Examples 1 and 2 the following compounds of formula I are produced |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In diethyl ether; ethanol; | EXAMPLE 1A 5-Amino-1-(2,6-dimethylphenyl)-1H-pyrazole-4-carbonitrile 3.0 g (17.3 mmol) of <strong>[2538-61-6]2,6-dimethylphenylhydrazine hydrochloride</strong> are suspended with 2.1 g (17.3 mmol) of ethoxymethylenemalononitrile in 40 ml of ethanol, and 7.3 ml (52.1 mmol) of triethylamine are added. The reaction mixture is heated to reflux for 3 h, during which a clear solution forms. After cooling to room temperature, diethyl ether is added to this. The triethyl-ammonium chloride which precipitates is filtered off. The solvent is removed in vacuo, and the residue is purified by preparative HPLC (YMC gel ODS-AQ S 5/15 mum; eluent A: water, eluent B: acetonitrile; gradient: 0 min 30% B, 5 min 30% B, 50 min 95% B). 2.3 g (62% of theory) of the product are obtained as yellow crystals. LC-MS (Method 6): Rt=2.77 min. MS (ESI pos): m/z=213 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | To a mixture of concentrated HCl (50 mL) and water (40 mL) was added 2,6-dimethylaniline (24.2 g, 0.2 mol) under vigorous stirring. The resulting mixture was cooled to -4 C, and a solution of NaNO2 (15.2 g, 0.22 mol) in water (30 mL) was added dropwise to maintain temperature below 0 C. After addition of the sodium nitrite solution, the reaction mixture was stirred for 30 min. A solution of stannous dichloride hydrate (112.8 g, 0.5 mol) in 160 mL of 6 mol/L hydrochloric acid was added over a period of 1.5 h, during which the temperature of the reaction mixture was maintained below 5 C. The yellowish slurry was allowed to stand overnight at room temperature and stirring was continued for another 22 h. And then the mixture was cooled by ice-water for 1 h. The pale yellow tin complex salt was collected by filtration, dried on the funnel and washed with brine (50 mL), and ether (2×50 mL). The dry complex salt was stirred in water (100 mL), and slurry was stirred vigorously while it was treated with 10 mol/L NaOH (100 mL). The temperature of the mixture was maintained below 15 C. The crude hydrazine was extracted from the mixture with ether (2×200 mL), and the etheral solution was washed with water (200 mL) and dried over Na2SO4. The dried etheral solution was diluted with ether to 500 mL. The diluted solution was treated with 4.8 mol/L HCl in 1,4-dioxane (50 mL) until precipitation of the hydrazine hydrochloride was complete. The filtered hydrochloride was washed with ether (50 mL), dried over Na2SO4, and recrystallized from ethanol to afford 2,6-dimethylphenylhydrazine hydrochloride salt as colorless crystals 21.9 g in 63% yield. 4.2.1. 2,6-Dimethylphenylhydrazine hydrochloride salt. Colorless crystals, mp 210-212 C dec (Lit.15 211 C dec), 1H NMR (300 MHz, DMSO-d6) delta: 2.39 (s, 6H), 6.71 (br s, 1H), 7.08 (s, 3H), 9.82 (s, 3H). 13C NMR (50 MHz, DMSO-d6) delta: 140.6, 134.9, 128.6, 126.9, 18.0. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium acetate; In ethanol; at 78℃; | General procedure: A mixture of compound 5 (0.360 g, 1 mmol) and various phenylhydrazines 6a-6ad (0.145-0.225 g,1 mmol) in dry EtOH (10 mL) were stirred at 78C in the presence of CH3COONa (0.099 g,1.2 mmol). After completion of the reaction monitored by TLC, the solution was then poured into water (10 mL), the white precipitate was filtered and washed with water and dried. The crude product was recrystallized from ethyl acetate/light petroleum ether to give compounds 7a-7ad. Then to a solution of compounds 7a-7ad(0.450-0.529 g, 1 mmol) in toluene (5 mL), 48% BF3*OEt2 (48% solution in Et2O, 0.05 mL, 0.17 mmol) was added dropwise and the mixture was heated under a nitrogen atmosphere at 118C. After completion of the reaction monitored by TLC, water (10 mL) was added to the mixture, which was next neutralized with NaHCO3, and the organic phase was separated and dried over Na2SO4. After evaporation in vacuo, the crude product was purified by column chromatography to give product 9a-9ad. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | In isopropyl alcohol;Reflux; | General procedure: A mixture of compound 10 (0.376 g, 1 mmol) and various phenylhydrazines 6a-6ad (0.145-0.225 g, 1 mmol) in isopropanol (10 mL) were stirred under reflux. After completion of the reaction monitored by TLC, the reaction mixture was concentrated under vacuum, and extracted with CH3CO2C2H5 and H2O. At last the organic layer was washed with saturated NaCl aqueous solution, dried with Na2SO4 and concentrated under vacuum. The residue was purified by column chromatography on silica to give product 11a-11ad. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium methylate; In ethanol; cyclohexane; water; ethyl acetate; acetonitrile; | Step 1: 1-(2,6-Dimethylphenyl)-1H-pyrazole-3-amine (via route B-1) 2,6-Dimethylphenylhydrazine hydrochloride (3.50 g) was initially charged in ethanol (30 ml), sodium methoxide solution (3.29 g in 20 ml of ethanol) and 3-ethoxyacrylonitrile (2.95 g) were added and the mixture was heated under reflux for 9 h and then stirred at room temperature overnight. The reaction mixture was then concentrated under reduced pressure, taken up in ethyl acetate, washed with water, dried over sodium sulphate and concentrated to dryness under reduced pressure. The residue was initially purified by column chromatography on silica gel using the mobile phase cyclohexane/ethyl acetate (gradient=2 h from 100% cyclohexane to 100% ethyl acetate) and then chromatographed by preparative HPLC using the mobile phase water/acetonitrile (gradient=40 min from 10% acetonitrile in water to 100% acetonitrile). This gave 39 mg of the title compound. HPLC-MS: log P=0.62; mass (m/z): 188.1 (M+H)+; 1H-NMR (CD3CN) 2.00 (s, 6H), 4.03 (br. s, 2H), 5.57 (d, 1H), 7.21-7.23 (m, 2H), 7.30-7.33 (m, 1H), 7.36 (d, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With triethylamine; In tetrahydrofuran; at 20℃; | General procedure: To a mixture of an arylhydrazine hydrochloride salt (10 mmol) and triethylamine (1.5 mL, 1.09 g, 11 mmol) or to a solution of an arylhydrazine (10 mmol) in THF (30 mL) was added dropwise a solution of (Boc)2O (2.41 g, 11 mmol) in THF (20 mL) under stirring in an ice-water bath. The resulting mixture was stirred at room temperature for 2-3 h, filtered, and washed with diethyl ether. The filtrate was then washed successively with saturated sodium bicarbonate and brine. The organic layer was dried over anhydrous sodium sulfate, filtered, concentrated under reduced pressure, and purified by flash silica gel chromatography with a mixture of petroleum ether and ethyl acetate as an eluent to afford the desired product. 4.3.1 N?-Boc-N-(4-cyano-2,6-dimethylphenyl)hydrazine (7a). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With triethylamine; In dichloromethane; at 20℃; | Take 0.2mmol 2,6 dimethylphenylhydrazine hydrochloride was dissolved in 5mL of dichloromethane was added triethylamine 0.52mmol phenylhydrazine freed so, then under ice 2mL of dichloromethane was added to dissolve the product of 4-methylbenzoyl chloride 0.26mmol, the reaction mixture was stirred at room temperature, TLC monitored the reaction.After completion of the reaction the basic raw material, separated by column chromatography to give pure target compound product as a white solid, mp 139-142 ; 93% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With triethylamine; In dichloromethane; at 20℃; | Take 0.2mmol 2,6 dimethylphenylhydrazine hydrochloride was dissolved in 5mL of dichloromethane was added triethylamine 0.52mmol phenylhydrazine freed so, then under ice 2mL of dichloromethane was added to dissolve the product of 4-dimethylamino-benzoyl chloride 0.26mmol, the reaction mixture was stirred at room temperature, TLC monitored the reaction.After completion of the reaction the basic raw material, separated by column chromatography to give pure target compound product as a white solid, mp140-141 ; 81% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With triethylamine; In dichloromethane; at 20℃; | Take 0.2mmol 2,6 dimethylphenylhydrazine hydrochloride was dissolved in 5mL of dichloromethane was added triethylamine 0.52mmol phenylhydrazine freed so, then under ice 2mL of dichloromethane was added to dissolve the product of 4-methoxybenzoyl chloride 0.26mmol, the reaction mixture was stirred at room temperature, TLC monitored the reaction.After completion of the reaction the basic raw material, separated by column chromatography to give pure target compound product as a white solid, mp 180-181 ; 90% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With triethylamine; In dichloromethane; at 20℃; | Take 0.2mmol 2,6 dimethylphenylhydrazine hydrochloride was dissolved in 5mL of dichloromethane was added triethylamine 0.52mmol phenylhydrazine freed so, then under ice 2mL of dichloromethane was added to dissolve the product of 4-ethyl-benzoyl chloride 0.26mmol, the reaction mixture was stirred at room temperature, TLC monitored the reaction.After completion of the reaction the basic raw material, purified by column chromatography to give the title compound as a white solid product, the product as a white solid product as a white solid, mp 127-128 ; 91% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With triethylamine; In dichloromethane; at 20℃; | Take 0.2mmol 2,6 dimethylphenylhydrazine hydrochloride was dissolved in 5mL of dichloromethane was added triethylamine 0.52mmol phenylhydrazine freed so, then under ice 2mL of dichloromethane was added to dissolve the product of 4-propylbenzoyl chloride 0.26mmol, the reaction mixture was stirred at room temperature, TLC monitored the reaction.After completion of the reaction the basic raw material, separated by column chromatography to give pure target compound product as a white solid, mp 117-118 ; 93% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With triethylamine; In dichloromethane; at 20℃; | Take 0.2mmol 2,6 dimethylphenylhydrazine hydrochloride was dissolved in 5mL of dichloromethane was added triethylamine 0.52mmol phenylhydrazine freed so, then under ice 2mL of dichloromethane was added to dissolve the product of tert-butylbenzoyl chloride 0.26mmol, the reaction mixture was stirred at room temperature, TLC monitored the reaction.After completion of the reaction the basic raw material, separated by column chromatography to give pure target compound product as a white solid, mp 155-156 ; 92% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With acetic acid; In ethanol; at 50℃; | To tert-butyl 3-cyano-4-oxo-pyrrolidine-1-carboxylate (19.5 g, 92.54 mmol) and <strong>[2538-61-6](2,6-dimethylphenyl)hydrazine hydrochloride</strong> (16 g, 92.65 mmol) were added EtOH (160 mL) and AcOH (40 mL). The resulting suspension was stirred at 50 C overnight. Upon completion, the reaction mixture was quenched with 1N NaOH aqueous solution and extracted with EtOAc ( 2 x 100 mL), dried (MgSO4), and concentrated in vacuo. The crude product was then purified by silica gel flash chromatography (50% EtOAc in hexanes) to obtain tert-butyl 3- amino-2-(2,6-dimethylphenyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carboxylate. MS: (ES) m/z calculated for C18H25N4O2 [M + H]+ 329.2, found 329.2. | |
With acetic acid; In ethanol; at 50℃; | To tert-butyl 3-cyano-4-oxo-pyrrolidine-1-carboxylate (19.4 g, 92.3 mmol) and <strong>[2538-61-6](2,6-dimethylphenyl)hydrazine hydrochloride</strong> (16.0 g, 92.7 mmol) were added EtOH (160 mL) and AcOH (40 mL). The resulting suspension was stirred at 50 C. overnight. Upon completion, the reaction mixture was quenched with 1 N NaOH aqueous solution and extracted with EtOAc, dried over MgSO4, filtered, and concentrated in vacuo. The crude product was then purified by silica gel flash chromatography (50% EtOAc in hexanes) to obtain tert-butyl 3-amino-2-(2,6-dimethylphenyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carboxylate. MS: (ES) m/z calculated for C18H25N4O2 [M+H]+ 329.2, found 329.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
[0280] Step a: N,N-diisopropylethylamine (6 mL, 34.5 mmol) was added to a mixture of (2,6- dimethylphenyl)hydrazine hydrochloride (5 g, 28.9 mmol), tert-butyl 3-cyano-4-oxopiperidine- 1-carboxylate (5 g, 22.3 mmol) and EtOH (60 mL) in a 250 mL round bottom flask under magnetic stirring. The resulting mixture was stirred under reflux for 3 h. Glacial acetic acid (6 mL, 104 mmol) was added and the mixture was stirred under reflux for another 2 h. After removal of solvent under reduced pressure, the residue was dissolved in EtOAc and washed with aqueous NaOH (2N), brine and dried over MgSO4. The solvent was removed under reduced pressure and the residue was purified by silica gel flash chromatography (5 to 55% EtOAc in hexanes) to give tert-butyl 3-amino-2-(2,6-dimethylphenyl)-6,7-dihydro-2H-pyrazolo[4,3- c]pyridine-5(4H)-carboxylate . MS: (ES) m/z calculated for C19H27N4O2 [M + H]+ 343.2, found 343.2. Caution: Diazonium formation could be potentially dangerous, please handle with care and ware proper personal protection equipment. |
Tags: 2538-61-6 synthesis path| 2538-61-6 SDS| 2538-61-6 COA| 2538-61-6 purity| 2538-61-6 application| 2538-61-6 NMR| 2538-61-6 COA| 2538-61-6 structure
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P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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