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[ CAS No. 2546-45-4 ]

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Chemical Structure| 2546-45-4
Chemical Structure| 2546-45-4
Structure of 2546-45-4 * Storage: {[proInfo.prStorage]}

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Product Details of [ 2546-45-4 ]

CAS No. :2546-45-4 MDL No. :MFCD01320776
Formula : C8H7F3OS Boiling Point : 199.1°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :208.20 g/mol Pubchem ID :-
Synonyms :

Safety of [ 2546-45-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 2546-45-4 ]

  • Downstream synthetic route of [ 2546-45-4 ]

[ 2546-45-4 ] Synthesis Path-Downstream   1~8

  • 1
  • 2-methyl-1-butanethiol [ No CAS ]
  • [ 2546-45-4 ]
  • (2-methylbutyl)(4-(trifluoromethoxy)phenyl)sulfane [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With Singacycle A1; lithium hexamethyldisilazane In toluene at 100℃; for 7h; Glovebox; Sealed tube; 9 General procedure for the catalytic aryl transfer with aryl ethers General procedure: In the glovebox, aryl methyl sulfane (0.5 mmol), alkyl thiol (2.0 equiv, 1 .0 mmol),LiHMDS (1 .3 ml, 1.0 M in toluene), and SingaCycle Al (0.4 mol%, 0.4 ml, 0.005 Min toluene) were added into an oven-dried 8 ml vial with a magnetic stirring bar, followed by addition of toluene (0.3 ml). The vial was sealed and removed out of the glovebox and heated to 100 00. After 12 h, the vial was cooled to room temperature. The reaction was diluted with ethyl acetate and washed withsaturated NaOH solution. The aqueous phase was extracted with ethyl acetate 3 times. The collected organic phases were dried over anhydrous Na2504. The solvent was removed under reduced pressure and the residue was purified by flash column chromatography to give the desired product.
  • 2
  • [ 2546-45-4 ]
  • C8H7F3O2S [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With 1,1,1,3',3',3'-hexafluoro-propanol; water; lithium perchlorate; acetic acid at 20℃; for 6h; Electrochemical reaction; chemoselective reaction;
  • 3
  • [ 2546-45-4 ]
  • 1-(methylsulfonyl)-4-(trifluoromethoxy)benzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With 1,1,1,3',3',3'-hexafluoro-propanol; water; lithium perchlorate; acetic acid at 20℃; for 8h; Electrochemical reaction; chemoselective reaction;
  • 4
  • [ 1569-69-3 ]
  • [ 2546-45-4 ]
  • cyclohexyl(4-(trifluoromethoxy)phenyl)sulfane [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With bis(1,5-cyclooctadiene)nickel (0); lithium hexamethyldisilazane; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 100℃; for 12h; Glovebox; Inert atmosphere;
  • 5
  • [ 616-38-6 ]
  • [ 94108-56-2 ]
  • [ 2546-45-4 ]
YieldReaction ConditionsOperation in experiment
62% With tin; water; potassium hydrogencarbonate; triphenylphosphine; sodium iodide at 120℃; for 48h; Sealed tube;
  • 6
  • [ 2546-45-4 ]
  • [ 777063-53-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: dichloromethane / 12 h / 20 °C 2: magnesium; lithium chloride; bis(triphenylphosphine)nickel(II) dichloride; 1,3-bis-(diphenylphosphino)propane / tetrahydrofuran / 12 h / 20 °C / Sealed tube; Inert atmosphere
  • 7
  • [ 2546-45-4 ]
  • [ 333-27-7 ]
  • dimethyl(4-(trifluoromethoxy)phenyl)sulfonium trifluoromethanesulfonate [ No CAS ]
YieldReaction ConditionsOperation in experiment
1600.1 mg In dichloromethane at 20℃; for 12h;
  • 8
  • [ 624-92-0 ]
  • [ 407-14-7 ]
  • [ 2546-45-4 ]
YieldReaction ConditionsOperation in experiment
Stage #1: 1-bromo-4-(trifluoromethoxy)benzene With magnesium In tetrahydrofuran; ethylene dibromide at 20℃; for 3h; Stage #2: Dimethyldisulphide In tetrahydrofuran; ethylene dibromide at 0 - 20℃; for 2h;
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