Alternatived Products of [ 25462-66-2 ]
Product Details of [ 25462-66-2 ]
CAS No. : | 25462-66-2 |
MDL No. : | MFCD01851377 |
Formula : |
C8H7Br2NO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
292.96
|
Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 25462-66-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 25462-66-2 ]
- Downstream synthetic route of [ 25462-66-2 ]
- 1
-
[ 3638-73-1 ]
-
[ 108-24-7 ]
-
[ 25462-66-2 ]
Yield | Reaction Conditions | Operation in experiment |
92% |
With triethylamine; In ethyl acetate; at 70℃; for 2h; |
3.1) In a 5 L three-necked flask, 836 g of compound III, 1500 mL of ethyl acetate and 900 mL of acetic anhydride were added and stirred for 10 min to obtain a mixture E; 3.2) Add 400 mL of triethylamine to vessel C where mixture E is located. Reflux at 70 C for 2 h to obtain a mixture F; 3.3) After filtering the mixture F, washing with ice ethanol, adjusting the pH to 8-10 with sodium hydroxide solution, and performing an ice bath; 3.4) The product precipitated after the ice bath in step 3.3) is filtered and washed with ice ethanol. Obtaining 2-acetamido-p-dibromobenzene, ie, compound 897.98 g (yield 92%); |
Reference:
[1]Chemistry - A European Journal,2001,vol. 7,p. 5118 - 5134
[2]Organic Letters,2001,vol. 3,p. 993 - 995
[3]Physical Chemistry Chemical Physics,2009,vol. 11,p. 3967 - 3976
[4]Patent: CN108623473,2018,A .Location in patent: Paragraph 0081; 0096-0100; 0125-0129; 0157-0161
[5]Chemistry - An Asian Journal,2016,vol. 11,p. 2016 - 2020
[6]Journal of the American Chemical Society,1993,vol. 115,p. 4935 - 4936
[7]Journal of the American Chemical Society,1994,vol. 116,p. 11723 - 11736
[8]Tetrahedron,2000,vol. 56,p. 225 - 231
[9]Chimia,2002,vol. 56,p. 494 - 499
[10]Tetrahedron,2004,vol. 60,p. 81 - 92
- 2
-
[ 25462-66-2 ]
-
[ 63837-11-6 ]
- 3
-
[ 25462-66-2 ]
-
[ 25462-61-7 ]
- 4
-
[ 25462-66-2 ]
-
[ 1141727-54-9 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1: sulfuric acid; nitric acid / water / 2 h / 6 °C / Inert atmosphere
2: hydrogenchloride / water / 41 h / Reflux; Inert atmosphere
3: hydrogenchloride; tin / water; ethanol / 16 h / 0 - 20 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; copper(l) iodide; triethylamine / 26 h / 80 °C / Inert atmosphere
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere |
|